1257867-34-7

Basic information

• Product Name: (3-methyl-N-tosylpyrrolidin-2-yl)methanol
• Synonyms: (3-methyl-N-tosylpyrrolidin-2-yl)methanol
• CAS NO: 1257867-34-7
• Molecular Weight: 269.365
• Mol File: 1257867-34-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-methyl-N-tosylpyrrolidin-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-methyl-N-tosylpyrrolidin-2-yl)methanol(1257867-34-7)
• EPA Substance Registry System: (3-methyl-N-tosylpyrrolidin-2-yl)methanol(1257867-34-7)

Safety Data

• Hazardous Substances Data: 1257867-34-7(Hazardous Substances Data)

Upstream product

• 104375-65-7 4-methyl-N-(3-methylpent-4-en-1-yl)benzenesulfonamide 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 
• 51174-44-8 3-methyl-4-penten-1-ol 

Downstream Products

• 1257867-21-2 3-methyl-N-tosylpyrrolidine-2-carbaldehyde 
• 96013-56-8 4-methyl-1-(toluene-4-sulfonyl)-piperidin-2-one 

Relevant articles and documents

NHC-Catalyzed intramolecular redox amidation for the synthesis of functionalized lactams

A very efficient NHC-catalyzed lactamization reaction is reported. For most cases, the ring expansion reaction proceeds to cleanly furnish five- and six-membered N-Ts and N-Bn lactams, without the need for further purification. Evidence is presented suggesting a dual role for the stoichiometric base: (1) deprotonation of the triazolium precatalyst and (2) activation of the nitrogen leaving group through hydrogen bonding.