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51174-44-8

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51174-44-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 51174-44-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,1,7 and 4 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 51174-44:
(7*5)+(6*1)+(5*1)+(4*7)+(3*4)+(2*4)+(1*4)=98
98 % 10 = 8
So 51174-44-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H12O/c1-3-6(2)4-5-7/h3,6-7H,1,4-5H2,2H3

51174-44-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-methylpent-4-en-1-ol

1.2 Other means of identification

Product number -
Other names 3-methyl-4-pentene-1-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:51174-44-8 SDS

51174-44-8Relevant articles and documents

A short stereoselective total synthesis of racemic patchouli alcohol: preliminary communication

Naef,Ohloff

, p. 1868 - 1870 (1974)

-

Pd(II)-Catalyzed [4 + 2] Heterocyclization Sequence for Polyheterocycle Generation

Glaisyer, Elizabeth L.,Watt, Michael S.,Booker-Milburn, Kevin I.

supporting information, p. 5877 - 5880 (2018/09/25)

A new Pd(II)-catalyzed cascade sequence for the formation of polyheterocycles, from simple starting materials, is reported. The sequence is applicable to both indole and pyrrole substrates, and a range of substituents are tolerated. The reaction is thought to proceed by a Pd(II)-catalyzed C-H activated Heck reaction followed by a second Pd(II)-catalyzed aza-Wacker reaction with two Cu(II)-mediated Pd(0) turnovers per sequence. The sequence can be considered a formal [4 + 2] heterocyclization.

COMPOUNDS THAT INHIBIT MCL-1 PROTEIN

-

Page/Page column 1196; 1197, (2017/09/15)

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Molecular basis for the enantio- and diastereoselectivity of burkholderia cepacia lipase toward γ-Butyrolactone primary alcohols

Eum, Heesung,Kazlauskas, Romas J.,Ha, Hyun-Joon

, p. 3585 - 3599 (2015/02/19)

Burkholderia cepacia lipase (BCL) shows high enantioselectivity toward chiral primary alcohols, but this enantioselectivity is often unpredictable, especially for substrates that contain an oxygen at the stereocenter. For example, BCL resolves bsubstituted- g-acetyloxymethyl-g-butyrolactones (acetates of a chiral primary alcohol) by hydrolysis of the acetate, but the enantioselectivity varies with the nature and orientation of the b-alkyl substituent. BCL favors the (R)-primary alcohol when the balkyl substituent is hydrogen (E=30) or trans methyl (E=38), but the (S)-primary alcohol when it is cis methyl (E=145). To rationalize this unusual selectivity, we used a combination of experiments to show the importance of polar interactions and modeling to reveal differences in orientations of the enantiomers. Removal of either the lactone carbonyl in the substrate or the polar side chains in the enzyme by using a related enzyme without these side chains decreased the enantioselectivity at least four-fold. Modeling revealed that the slow enantiomers do not bind by exchanging the location of two substituents relative to the fast enantiomer. Instead, three substituents remain in the same region, but the fourth substituent, hydrogen, inverts to a new location, like an umbrella in a strong wind. In this orientation the favored stereoisomers have similar shapes, thus accounting for the unusual stereoselectivity. The ratio of catalytically productive orientations for the fast vs. slow enantiomers in a molecular dynamic simulation correlated (R2=0.82) with the degree of enantioselectivity including the case where the enantioselectivity reversed. Weighting this ratio by the ratio of Hbonds in the polar interaction to account for different binding strengths improved the correlation with the measured enantioselectivity to R2=0.97. The modeling identifies key interactions responsible for high enantioselectivity in this class of substrates.

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