10439-77-7

Usage

Uses

Used in Dye Manufacturing Industry:
N-METHYL-4-NITRO-O-TOLUIDINE is used as an intermediate in the dye manufacturing process for its ability to contribute to the formation of various dye compounds.
Used in Chemical Production:
N-METHYL-4-NITRO-O-TOLUIDINE is used as a component in the production of other chemicals, highlighting its versatility in different chemical synthesis processes.
Safety and Environmental Considerations:
When handling N-METHYL-4-NITRO-O-TOLUIDINE, it is crucial to exercise caution due to its harmful effects if inhaled, swallowed, or if it comes into contact with the skin. Moreover, it is classified as hazardous for the environment, especially to aquatic life, necessitating proper disposal and handling protocols to minimize ecological impact.

Upstream product

• 99-52-5 2-methyl-4-nitro-benzenamine 
• 333-27-7 methyl trifluoromethanesulfonate 
• 616-38-6 carbonic acid dimethyl ester 
• 10596-01-7 N-methyl-N-nitroso-o-toluidine 
• 7664-93-9 sulfuric acid 
• 156461-85-7 N-methyl-N-nitro-o-toluidine 
• 64-19-7 acetic acid 
• 32417-73-5 N,2-dimethyl-5-nitroformanilide 
• 74-88-4 methyl iodide 
• 90918-52-8 acetic acid-(2,N-dimethyl-4-nitro-anilide) 
• 124-41-4 sodium methylate 
• 26198-11-8 N-formyl-2-methyl-4-nitroaniline 
• 6370-27-0 2,N-dimethyl-4-nitroso-aniline 
• 100-39-0 benzyl bromide 

Downstream Products

• 32417-73-5 N,2-dimethyl-5-nitroformanilide 

Relevant academic research and scientific papers

Self-Immolative System for Disclosure of Reactive Electrophilic Alkylating Agents: Understanding the Role of the Reporter Group

The development of stable, efficient chemoselective self-immolative systems, for use in applications such as sensors, requires the optimization of the reactivity and degradation characteristics of the self-immolative unit. In this paper, we describe the effect that the structure of the reporter group has upon the self-immolative efficacy of a prototype system designed for the disclosure of electrophilic alkylating agents. The amine of the reporter group (a nitroaniline unit) was a constituent part of a carbamate that functioned as the self-immolative unit. The number and position of substituents on the nitroaniline unit were found to play a key role in the rate of self-immolative degradation and release of the reporter group. The position of the nitro substituent (meta- vs para-) and the methyl groups in the ortho-position relative to the carbamate exhibited an influence on the rate of elimination and stability of the self-immolative system. The ortho-methyl substituents imparted a twist on the N-C (aromatic) bond leading to increased resonance of the amine nitrogen's lone pair into the carbonyl moiety and a decrease of the leaving character of the carbamate group; concomitantly, this may also make it a less electron-withdrawing group and lead to less acidification of the eliminated β-hydrogen.

SELF-IMMOLATIVE SYSTEMS

The present invention is concerned with self-immolative recognition and/or responsive systems for electrophilic compounds, especially alkylating agents, which systems may comprise disclosure or detection of the alkylating agent. The present invention is especially concerned with non-protic triggered self-immolative systems, molecules, and methods, and in particular for detection of non- protic electrophilic agents, and especially alkylating agents, for example alkyl or benzylic halides, which may be found in pesticides or fumigants, or chemical warfare agents.

N-Methylation of poorly nucleophilic aromatic amines with dimethyl carbonate

Abstract: Dimethyl carbonate (DMC), an environmentally friendly methylation agent, is a substitute for traditional methylation agents such as methyl halides (CH3X, X?=?I, Br, Cl) or dimethyl sulfate. An efficient, convenient, and green method has been developed for N-methylation of poorly nucleophilic aromatic amines with DMC. It was found that the couple PEG400/K2CO3 provides good selectivity for the N-methylation product. Finally, the mechanism for reaction of amines with DMC was investigated, and a plausible multistep mechanism proposed and verified. Graphical Abstract: [Figure not available: see fulltext.]

Compounds which are ethylenically unsaturated in the terminal position, and the use thereof in nonlinear optics

The novel compounds of the general formula I STR1 where X is straight-chain or branched alkanediyl having from 1 to 20 carbon atoms or X is straight-chain or branched alkanediyl having from 2 to 20 carbon atoms, whose carbon chain is interrupted by --O--,

Organophosphorus Compounds. XX. Approaches to the Synthesis of 2,3-Dihydro-1H-1.2-benzazaphospholes Involving C-C and C-P Ring Closure

Reaction of chloromethylphosphonic dichloride (9) with N-methylaniline gave N,N'-dimethyl-N,N'-diphenylchloromethylphosphonodiamide (10) which upon treatment with aluminium chloride underwent intramolecular Friedel-Crafts alkylation to afford 1-methyl-2-(N'-methyl-N'-phenylamino)-2,3-dihydro-1H-1,2-benzazaphosphole 2-oxide (13a).Similarly, N-methyl-N-phenyl(chloromethyl)phenylphosphinamide (15) was cyclized to give 1-methyl-2-phenyl-2,3-dihydro-1H-1,2-benzazaphosphole 2-oxide (13b). Some unsuccessful approaches to this heterocyclic ring system are also reported.

Oxidative hair dye compositions

Oxidative hair dye composition containing as "para component" compounds of the formula: SPC1 Or their acid addition salts, in which: R1 is alkyl or hydroxyalkyl; R2 is hydrogen or hydroxyalkyl; R3 is hydrogen, alkyl, alkoxy or halogen; and R4 occupies any one of the remaining positions on the benzene radical and is hydrogen, alkyl, alkoxy or halogen; providing that R2 is hydrogen when R3 is alkyl, alkoxy or halogen and providing that at least two of R1, R2, R3 or R4 are other than hydrogen.