10445-92-8

Basic information

• Product Name: Pyridine, 2-(1-chloroethyl)- (7CI,8CI,9CI)
• Synonyms: Pyridine, 2-(1-chloroethyl)- (7CI,8CI,9CI)
• CAS NO: 10445-92-8
• Molecular Formula: C₇H₈ClN
• Molecular Weight: 141.59812
• Product Categories: PYRIDINE
• Mol File: 10445-92-8.mol

Chemical Properties

• Boiling Point: 192℃
• Flash Point: 87℃
• Appearance: /
• Density: 1.109
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Pyridine, 2-(1-chloroethyl)- (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(1-chloroethyl)- (7CI,8CI,9CI)(10445-92-8)
• EPA Substance Registry System: Pyridine, 2-(1-chloroethyl)- (7CI,8CI,9CI)(10445-92-8)

Safety Data

• Hazardous Substances Data: 10445-92-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Pyridine, 2-(1-chloroethyl)(7CI,8CI,9CI) is utilized as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, Pyridine, 2-(1-chloroethyl)(7CI,8CI,9CI) serves as a valuable compound for studying the properties and reactions of Pyridine derivatives. It aids in understanding the reactivity and selectivity of the chloroethyl group in various chemical transformations.
Used in Agrochemical Industry:
Pyridine, 2-(1-chloroethyl)(7CI,8CI,9CI) is employed as a building block in the development of agrochemicals, such as pesticides and herbicides. Its unique structure contributes to the design of novel and effective agrochemicals for crop protection.
Used in Material Science:
In material science, Pyridine, 2-(1-chloroethyl)(7CI,8CI,9CI) is used in the synthesis of advanced materials with specific properties. Its incorporation into polymers or other materials can lead to the development of new materials with improved characteristics for various applications.
Used in Analytical Chemistry:
Pyridine, 2-(1-chloroethyl)(7CI,8CI,9CI) can be employed as a reagent or a reference compound in analytical chemistry. Its unique structure and properties make it suitable for use in various analytical techniques, such as chromatography, spectroscopy, and titration.

Upstream product

• 100-71-0 2-Ethylpyridine 
• 4833-24-3 2-ethylpyridine 1-oxide 
• 74405-07-5 4-chloro-2,2-dimethyl-2H-benzo[e][1,3]oxazine 
• 54856-82-5 3-methyl-[1,2,3]triazolo[1,5-a]pyridine 
• 98-09-9 benzenesulfonyl chloride 
• 67-64-1 acetone 
• 20988-55-0 1-(pyridine-2-yl)ethanol 
• 1122-62-9 2-acetylpyridine 
• 4377-33-7 2-chloromethylpyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 1122-62-9 2-acetylpyridine 

Relevant articles and documents

Orientation towards asymmetric transfer hydrogenation of ketones catalyzed by (pyrazolyl)ethyl)pyridine Fe(II) and Ni(II) complexes

Compounds 2-[1-(3,5-dimethylpyrazol-1-yl)ethyl]pyridine (L1) and 2-[1-(3,5-diphenylpyrazol-1-yl)ethyl]pyridine (L2) were obtained in a three-step procedure which involved the reduction of acetylpyridine using NaBH4, chlorination of the alcohol intermediate using SOCl2 and subsequent reaction with appropriate pyrazoles. Reactions of L1 and L2 with Ni(II) and Fe(II) halides produced the respective complexes Ni(L1)Br2 (1), Ni(L1)Cl2 (2), Fe(L1)Cl2 (3) and Ni(L2)Br2 (4) as racemic mixtures in moderate yields. The molecular structures of complexes 1 and 4 are dinuclear and mononuclear respectively. All the complexes (1–4) formed active catalysts for the transfer hydrogenation of ketones (THK) in 2-propanol at 82?°C affording conversions of 58%–84% within 48?h. The influence of catalyst structure, reaction conditions and identity of ketone substrates in the TH reactions have been successfully established.

PYRAZOLE DERIVATIVES AND USES THEREOF AS INHIBITORS OF DLK

The present invention provides for compounds of formula 0 and various embodiments thereof, and compositions comprising compounds of formula 0 and various embodiments thereof. In compounds of formula 0, the groups R1A, R1B, R1C, R1D, R2, R3, R4, R5 and R6 have the meaning as described herein. The present invention also provides for methods of using compounds of formula 0 and compositions comprising compounds of formula 0 as DLK inhibitors and for treating neurodegeneration diseases and disorders.

SUBSTITUTED PYRAZOLES AND USES THEREOF

The present invention provides for compounds of formula 0 and various embodiments thereof, and compositions comprising compounds of formula 0 and various embodiments thereof. In compounds of formula 0, the groups R1A, R1B, R1C, R1D, R2, R3, R4, R5 and R6 have the meaning as described herein. The present invention also provides for methods of using compounds of formula 0 and compositions comprising compounds of formula 0 as DLK inhibitors and for treating neurodegeneration diseases and disorders.

Mechanistic studies of the ring opening reactions of [1,2,3]triazolo[1,5-a]pyridines

A mechanism with radical intervention is proposed for the opening of the triazole ring in [1,2,3] triazolo[1,5-a]pyridines which results in the production of 2- or 2,6-disubstituted pyridines.

Lithiation of 2-chloromethylpyridine: Synthesis of 2-oxiranyl pyridines

Deprotonation of 2-chloromethylpyridine 1a with lithium diisopropylamide (LDA) in tetrahydrofuran (THF) at -78°C gives a red solution of 2-pyridiylchloromethyllithium 1b, which reacts with carbonyl compounds furnishing oxiranes 2.

Side chain chlorination process of heterocycles

A novel method of chlorinating the alkyl side chains of a nitrogen containing heterocyclic comprising reacting an alkyl substituted heterocycle with trichloroisocyanuric acid at temperatures of 20° to 200° C. to obtain the same in high yields.

Side Chain Chlorinations of N-Heterocyclic Compounds by Trichloroisocyanuric Acid (TCC)

N-Heterocyclic compounds such as 2-methylpyridines, 2-methylquinoline, and 2-methylquinoxaline react with trichloroisocyanuric acid (TCC) without the addition of an initiator to provide the corresponding chloromethyl derivatives in good yields.

Studies on 1,3-Benzoxazines. II. New Rearrangement Modes in the Reaction of 4-Chloro-2,2-dimethyl-2H-1,3-benzoxazine with Substituted Pyridine N-Oxides

New rearrangement modes in the reaction of 4-chloro-2,2-dimethyl-2H-1,3-benzoxazine (1) with various α- and/or γ-substituted pyridine N-oxides are described.The benzoxazine moiety was introduced into the side chain and/or β-position of the pyridine ring, in addition to the α-position.Possible mechanism of the reactions are discussed.Keywords - 1,3-benzoxazine; picoline N-oxide; lutidine N-oxide; imidoyl chloride; rearrangement.