10445-92-8Relevant articles and documents
Orientation towards asymmetric transfer hydrogenation of ketones catalyzed by (pyrazolyl)ethyl)pyridine Fe(II) and Ni(II) complexes
Magubane, Makhosazane N.,Alam, Mohd Gulfam,Ojwach, Stephen O.,Munro, Orde Q.
, p. 197 - 201 (2017)
Compounds 2-[1-(3,5-dimethylpyrazol-1-yl)ethyl]pyridine (L1) and 2-[1-(3,5-diphenylpyrazol-1-yl)ethyl]pyridine (L2) were obtained in a three-step procedure which involved the reduction of acetylpyridine using NaBH4, chlorination of the alcohol intermediate using SOCl2 and subsequent reaction with appropriate pyrazoles. Reactions of L1 and L2 with Ni(II) and Fe(II) halides produced the respective complexes Ni(L1)Br2 (1), Ni(L1)Cl2 (2), Fe(L1)Cl2 (3) and Ni(L2)Br2 (4) as racemic mixtures in moderate yields. The molecular structures of complexes 1 and 4 are dinuclear and mononuclear respectively. All the complexes (1–4) formed active catalysts for the transfer hydrogenation of ketones (THK) in 2-propanol at 82?°C affording conversions of 58%–84% within 48?h. The influence of catalyst structure, reaction conditions and identity of ketone substrates in the TH reactions have been successfully established.
SUBSTITUTED PYRAZOLES AND USES THEREOF
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Paragraph 0249; 0250, (2015/07/02)
The present invention provides for compounds of formula 0 and various embodiments thereof, and compositions comprising compounds of formula 0 and various embodiments thereof. In compounds of formula 0, the groups R1A, R1B, R1C, R1D, R2, R3, R4, R5 and R6 have the meaning as described herein. The present invention also provides for methods of using compounds of formula 0 and compositions comprising compounds of formula 0 as DLK inhibitors and for treating neurodegeneration diseases and disorders.
Lithiation of 2-chloromethylpyridine: Synthesis of 2-oxiranyl pyridines
Florio,Troisi
, p. 3175 - 3178 (2007/10/02)
Deprotonation of 2-chloromethylpyridine 1a with lithium diisopropylamide (LDA) in tetrahydrofuran (THF) at -78°C gives a red solution of 2-pyridiylchloromethyllithium 1b, which reacts with carbonyl compounds furnishing oxiranes 2.