104465-70-5Relevant articles and documents
NAD(P)H-NAD(P)+ Models. 73. Structure-Stereochemistry Relationship in the Reaction of NAD Analog
Ohno, Atsuyoshi,Mikata, Yuji,Goto, Mutsuo,Kashiwagi, Takeshi,Tanaka, Takanori,Sawada, Masami
, p. 81 - 86 (2007/10/02)
Four different NAD(P)H analogs have been oxidized by various substituted and unsubstituted 1,4-benzoquinones in the presence or absence of magnesium ion.The stereospecificity of the reaction depends not only on the reactivity of quinone but also on that of the analogs as well as on the presence or absence of magnesium ion.The results are discussed from the viewpoint of reaction mechanism for the transfer of a (net) hydride ion.
NAD(P)+-NAD(P)H MODELS. 57. STEROCHEMISTRY IN (NET) HYDRIDE TRANSFER FROM AND TO NAD(P)+-NAD(P)H MODELS: CHIRALITY SINK
Ohno, Atsuyoshi,Kashiwagi, Masanori,Ishihara, Yuji,Ushida, Satoshi,Oka, Shinzaburo
, p. 961 - 974 (2007/10/02)
NAD(P)H/NAD(P)+ and related compounds have intrinsic chirality against the axis along the C3-Ccarbonyl single bond.A model compound which has a stable conformation with respect to this chirality was synthesized and the conformational relationship between the carbonyl dipole and the reacting hydrogen was studied.It has been concluded that there is a relationship between conformations of these groups both in reduction and in oxidation provided the substrate is a neutral species.The result is discussed in relation with the hypothesis proposed previously on the basis of quantum chemical calculations.