104785-55-9

Basic information

• Product Name: 2,4-DIMETHYLQUINOLINE-3-CARBOXYLIC ACID
• Synonyms: 3-Quinolinecarboxylic acid, 2,4-dimethyl-
• CAS NO: 104785-55-9
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.23
• Mol File: 104785-55-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 354.1°Cat760mmHg
• Flash Point: 167.9°C
• Appearance: /
• Density: 1.243g/cm³
• Vapor Pressure: 1.26E-05mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-DIMETHYLQUINOLINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHYLQUINOLINE-3-CARBOXYLIC ACID(104785-55-9)
• EPA Substance Registry System: 2,4-DIMETHYLQUINOLINE-3-CARBOXYLIC ACID(104785-55-9)

Safety Data

• Statements: 20/21/22
• Safety Statements: 36/37
• Hazardous Substances Data: 104785-55-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C12H11NO2/c1-7-9-5-3-4-6-10(9)13-8(2)11(7)12(14)15/h3-6H,1-2H3,(H,14,15)/p-1

Upstream product

• 141-97-9 ethyl acetoacetate 
• 551-93-9 2-aminoacetophenone 
• 105-45-3 acetoacetic acid methyl ester 
• 7647-01-0 hydrogenchloride 
• 859959-35-6 2,4-dimethylquinoline-3-carbonitrile 
• 104785-54-8 2,4-dimethylquinoline-3-carboxylic acid ethyl ester 

Downstream Products

• 104785-63-9 1,2,4-Trimethyl-3-[methyl-((R)-1-phenyl-ethyl)-carbamoyl]-quinolinium; iodide 
• 104785-59-3 11R-3-(N-α-methylbenzyl)carbamoyl-1,2,4-trimethylquinolinium iodide 
• 104465-71-6 4S,11R-3-(N-methyl-N-α-methylbenzyl)carbamoyl-1,2,4-trimethyl-1,4-dihydroquinoline 
• 104785-60-6 4S,11S-3-(N-α-methylbenzy)carbamoyl-1,2,4-trimethyl-1,4-dihydroquinoline 
• 104785-57-1 (4R)-3-(N-(R)-α-methylbenzylcarbamoyl)-1,2,4-trimethyl-1,4-dihydroquinoline 
• 83670-13-7 3-(N-(R)-α-methylbenzylcarbamoyl)-1,2,4-trimethyl-1,4-dihydroquinoline 
• 104465-70-5 (4R)-3--1,2,4-trimethyl-1,4-dihydroquinoline 
• 104785-59-3 (13S)-1,2,4-trimethyl-3-(N-α-methylbenzylcarbamoyl)quinolinium iodide 
• 104785-56-0 11R-3-(N-α-methylbenzyl)carbamoyl-2,4-dimethylquinoline 

Relevant articles and documents

Microwave-assisted Friedl?nder synthesis of quinolines derivatives as potential antiparasitic agents

A series of substituted quinolines was developed via the Friedl?nder reaction employing microwave irradiation (MW), in the presence of a catalytic amount of hydrochloric acid. The products were obtained in good yields in 1.5-12 min and were tested in vitr

Quinoline- and 1,8-naphthyridine-3-carboxylic acids using a self-catalyzed Friedl?nder approach

One-step syntheses of 2-alkyl- and 2,4-dialkyl-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids are reported using a catalyst-free Friedl?nder reaction. The reaction is carried out in one step by simple heating of 2-aminobenzaldehyde, 2-amino-5-chlorobenzaldehyde, 2-aminonicotinaldehyde, or 2-aminoacetophenone with a β-ketoester in toluene or xylene for 24 h. Under these conditions, the carboxylic acid product is isolated directly from the reaction mixture without need for further purification. The observation that the reaction starts slowly and accelerates as it proceeds suggests that the transformation is self-catalyzed. This hypothesis is also supported by the finding that attempts to extend the current reaction to diketones, which cannot hydrolyze to an acid, were generally unsuccessful.

NAD(P)+-NAD(P)H MODELS. 57. STEROCHEMISTRY IN (NET) HYDRIDE TRANSFER FROM AND TO NAD(P)+-NAD(P)H MODELS: CHIRALITY SINK

NAD(P)H/NAD(P)+ and related compounds have intrinsic chirality against the axis along the C3-Ccarbonyl single bond.A model compound which has a stable conformation with respect to this chirality was synthesized and the conformational relationship between the carbonyl dipole and the reacting hydrogen was studied.It has been concluded that there is a relationship between conformations of these groups both in reduction and in oxidation provided the substrate is a neutral species.The result is discussed in relation with the hypothesis proposed previously on the basis of quantum chemical calculations.