104785-54-8Relevant articles and documents
New inorganic-organic hybrid materials based on SBA-15 molecular sieves involved in the quinolines synthesis
López-Sanz, Jesús,Pérez-Mayoral, Elena,Soriano, Elena,Sturm, Marina,Martín-Aranda, Rosa María,López-Peinado, Antonio J.,?ejka, Ji?í
, p. 97 - 103 (2012)
In this paper we report on the first mesoporous catalyst based on SBA-15 incorporating simultaneously basic and acid functions able to promote the Friedl?nder reaction between 2-aminoaryl ketones and ethyl acetoacetate leading to quinolines 1 with high yi
Flexible Zn-MOF Exhibiting Selective CO2 Adsorption and Efficient Lewis Acidic Catalytic Activity
Agarwal, Rashmi A.,Gupta, Anoop K.,De, Dinesh
, p. 2010 - 2018 (2019)
A two-dimensional, tetragonal porous metal organic framework {[Zn2(TBIB)2(HTCPB)2]·9DMF·19H2O}n (1) has been synthesized under hydrothermal conditions by employing 1,3,5-tri(1H-benzo[d]imidazol-1-yl)b
Synthesis of novel quinoline-thiosemicarbazide hybrids and evaluation of their biological activities, molecular docking, molecular dynamics, pharmacophore model studies, and ADME-Tox properties
Darji, Drashti G.,Patel, Dhaval B.,Patel, Hitesh D.,Patel, Krupa R.,Rajani, Dhanji P.,Rajani, Smita D.
, (2020)
In the present study, a novel series of N-((substituted)carbamothioyl)-2,4-dimethylquinoline-3-carboxamide (7a-7s) was synthesized by microwave-assisted method. Structure of these derivatives was examined by spectroscopic techniques such as 1H NMR, 13C NMR, FT-IR, and ESI-MS. Further, the novel synthesized compounds were evaluated for their in-vitro biological activities against antibacterial, antifungal, antimalarial, and antituberculosis activity as well as for in-silico study. The antimalarial results demonstrated that compounds 7c and 7q (0.02 μg/mL) have notable potency against Plasmodium falciparum compared with chloroquine (0.02 μg/mL); compounds 7l (0.10 μg/mL), 7e, 7s (0.19 μg/mL), 7b, 7p (0.15 μg/mL), 7a, 7f, and 7f (0.25 μg/mL) also exhibited good activity against P. falciparum compared with quinine (0.26 μg/mL) as standard drug. Docking was performed on PFDHFR-TS, given the effect of compounds against the P. falciparum strain was excellent in comparison with standard drug. Molecular docking suggested that compounds 7b, 7i and 7c, 7e, and 7l closely bind with the active site of protein 3JSU and 4DP3, respectively, and compared with biological activity. We have also carried out molecular dynamics simulation on the best dock compound 7e complex with PDB: 3JSU to check the stability of docked complex and their molecular interaction. The calculated ADME-Tox descriptors for the synthesized compounds validated good pharmacokinetics properties, suggesting that these compounds could be used as hit for the development of the new active agents.
Titania nanomaterials: Efficient and recyclable heterogeneous catalysts for the solvent-free synthesis of poly-substituted quinolines via Friedlander hetero-annulation
Bandyopadhyay, Prabal,Prasad,Sathe, Manisha,Sharma, Pratibha,Kumar, Ashok,Kaushik
, p. 6638 - 6645 (2014)
The present communication describes the use of titania (TiO2) nanomaterials of different sizes (16 nm, 35 nm, 70 nm, 200 nm, and 1000 nm) as heterogeneous catalysts for the preparation of a series of medicinally significant poly-substituted qui
Magnetite (Fe3O4) nanoparticles-supported dodecylbenzenesulfonic acid as a highly efficient and green heterogeneous catalyst for the synthesis of substituted quinolines and 1-amidoalkyl-2-naphthol derivatives
Katheriya, Deepak,Patel, Nipun,Dadhania, Harsh,Dadhania, Abhishek
, p. 805 - 816 (2020/10/02)
Abstract: Magnetically retrievable, magnetite (Fe3O4) nanoparticles-supported dodecylbenzenesulfonic acid (DDBSA@MNP) was synthesized and characterized through different analytical techniques such as TEM, XRD, FTIR, TGA, SEM, EDX and
An environmentally benign, green, and efficient ionic liquid catalyzed synthesis of Quinoline derivatives via Knoevenagel condensation
Tasqeeruddin, Syed,Asiri, Yahya I.
, p. 132 - 139 (2019/12/12)
The present investigation is in the interest of one-pot, environmentally friendly and efficient protocol for the synthesis of quinoline derivatives from 2-aminoarylketones and active methylene compounds in the presence of L-proline and ionic liquid 1,3-di
