104615-49-8

Basic information

• Product Name: Carbamic acid, (4-chloro-2-cyanophenyl)-, ethyl ester
• CAS NO: 104615-49-8
• Molecular Formula: C10H9ClN2O2
• Molecular Weight: 224.647
• Mol File: 104615-49-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (4-chloro-2-cyanophenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (4-chloro-2-cyanophenyl)-, ethyl ester(104615-49-8)
• EPA Substance Registry System: Carbamic acid, (4-chloro-2-cyanophenyl)-, ethyl ester(104615-49-8)

Safety Data

• Hazardous Substances Data: 104615-49-8(Hazardous Substances Data)

Upstream product

• 41534-70-7 (2-cyanophenyl)carbamic acid ethyl ester 
• 1885-29-6 anthranilic acid nitrile 
• 5922-60-1 2-amino-5-chlorobenzonitrile 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 104615-00-1 9-chloro-2-(2-furyl)-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)one 
• 1012369-92-4 1-ethoxycarbonyl-2-(3,4,5-trimethoxybenzoyl)-3-amino-5-chloro-1H-indole 
• 220269-85-2 ethyl 3-amino-5-chloro-2-(3-chlorobenzoyl)-1H-indole-1-carboxylate 
• 41011-01-2 2-bromo-1-(3-chloro-phenyl)-ethanone 
• 104615-18-1 9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-C]quinazolin-5-amine 
• 113686-04-7 4-Chloro-2-<3-(2-furanyl)-1H-1,2,4-triazol-5-yl>benzeneamine 

Relevant articles and documents

[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES

The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I) in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

Expedient one-pot synthesis of indolo[3,2-c]isoquinolines via a base-promoted N-Alkylation/tandem cyclization

A transition metal-free, one-pot protocol has been developed for the synthesis of 11H-indolo[3,2-c]isoquinolin-5-amines via the atom economical annulation of ethyl (2-cyano-phenyl)carbamates and 2-cyanobenzyl bromides. This method proceeds via sequential

Synthesis and biological evaluation of 1-methyl-2-(3′,4′, 5′-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors

The 2-(3,4,5-trimethoxybenzoyl)-2-aminoindole nucleus was used as the fundamental structure for the synthesis of compounds modified with respect to positions C-4 to C-7 with different moieties (chloro, methyl, or methoxy). Additional structural variations concerned the indole nitrogen, which was alkylated with small alkyl groups such as methyl or ethyl. We have identified 1-methyl-2-(3,4,5-trimethoxybenzoyl)-3-amino-7-methoxyindole as a new highly potent antiproliferative agent that targets tubulin at the colchicine binding site and leads to apoptotic cell death.