10466-37-2

Basic information

• Product Name: 4,4'-(1-METHYLENE) BIS-BENZONITRILE
• Synonyms: 4,4'-(1-METHYLENE) BIS-BENZONITRILE;4,4'-(1-Methylene);4-[(4-Cyanophenyl)methyl]benzonitrile;4,4'-Dicyanodiphenylmethane;Letrozole Impurity D
• CAS NO: 10466-37-2
• Molecular Formula: C₁₅H₁₀N₂
• Molecular Weight: 218.25
• Mol File: 10466-37-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 167 °C
• Boiling Point: 410.6 °C at 760 mmHg
• Flash Point: 199.6 °C
• Appearance: White solid
• Density: 1.17 g/cm³
• Storage Temp.: Room Temperature, under inert atmosphere
• Solubility: Chloroform (Slightly)
• CAS DataBase Reference: 4,4'-(1-METHYLENE) BIS-BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-(1-METHYLENE) BIS-BENZONITRILE(10466-37-2)
• EPA Substance Registry System: 4,4'-(1-METHYLENE) BIS-BENZONITRILE(10466-37-2)

Safety Data

• Hazardous Substances Data: 10466-37-2(Hazardous Substances Data)

Usage

General Description

4,4'-(1-METHYLENE) BIS-BENZONITRILE is a chemical compound with the molecular formula C16H12N2. It is a dinitrile derivative of benzophenone and is commonly used as a reagent for the synthesis of various organic compounds. This chemical is widely utilized in the pharmaceutical and agrochemical industries. It may also be used as a stabilizer in the polymer industry. Additionally, 4,4'-(1-METHYLENE) BIS-BENZONITRILE has potential applications in the production of specialty chemicals and dyes due to its unique chemical structure and reactivity. Overall, this compound plays a crucial role in various chemical processes and has diverse industrial applications.

Upstream product

• 101-77-9 4,4'-diamino diphenyl methane 
• 1941-86-2 bis(4-bromophenyl)methane 
• 544-92-3 copper(I) cyanide 
• 112809-51-5 letrozol 
• 75-09-2 dichloromethane 
• 623-00-7 4-bromobenzenecarbonitrile 
• 126747-14-6 4-cyanophenylboronic acid 
• 874-89-5 4-Cyanobenzyl alcohol 
• 623-03-0 4-Cyanochlorobenzene 
• 104-85-8 para-methylbenzonitrile 
• 874-86-2 4-cyanobenzyl chloride 
• 100-44-7 benzyl chloride 
• 14568-85-5 bis-(4-acetoxymethyl-phenyl)-methane 
• 67-37-8 4,4'-methylenedibenzaldehyde 

Downstream Products

• 31948-16-0 bis(4-benzoylphenyl)methane 
• 790-83-0 4,4'-methylenedibenzoic acid 
• 4934-35-4 4,4'-di-(aminomethyl)-diphenylmethane 
• 69545-39-7 4,4'-dicyanodiphenylbromomethane 
• 119597-24-9 bis-[4-(α-dehydro-benzhydryl)-phenyl]-methane 
• 103388-91-6 bis<(α,α-diphenyl-α-chloro)-p-tolyl>methane 
• 103389-01-1 bis-[4-(α-hydroxy-benzhydryl)-phenyl]-methane 
• 67-37-8 4,4'-methylenedibenzaldehyde 
• 1334667-31-0 1-(4,4'-dicyanodiphenylmethyl)-4-phenyl-1H-1,2,3-triazole 
• 1334667-32-1 1-(4,4'-dicyanodiphenylmethyl)-4-(phenoxymethyl)-1H-1,2,3-triazole 
• 1334667-33-2 1-(4,4'-dicyanodiphenylmethyl)-4-((4-chlorophenoxy)methyl)-1H-1,2,3-triazole 
• 1334667-34-3 1-(4,4'-dicyanodiphenylmethyl)-4-((4-cyanophenoxy)methyl)-1H-1,2,3-triazole 
• 1334667-35-4 1-(4,4'-dicyanodiphenylmethyl)-4-((4-nitrophenoxy)methyl)-1H-1,2,3-triazole 
• 1334667-36-5 1-(4,4'-dicyanodiphenylmethyl)-4-((p-tolyloxy)methyl)-1H-1,2,3-triazole 

Relevant articles and documents

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Dual Nickel- And Photoredox-Catalyzed Reductive Cross-Coupling of Aryl Halides with Dichloromethane via a Radical Process

The first catalytic strategy to harness a new chloromethane radical from dichloromethane under dual Ni/photoredox catalytic conditions has been developed. Compared with traditional two-electron reductive process associated with metallic reductants, this method via a single-electron approach can proceed under exceptionally mild conditions (visible light, ambient temperature, no strong base) and exhibits complementary reactivity patterns. It affords a broad scope of many functional groups, including alkenyl, which suffers cyclopropanation in previous routes. The diarylmethane-d2 compounds can be readily available with this transformation.

Preparation method of letrozole

The invention provides a preparation method of letrozole (6). The preparation method comprises the following steps: reacting a compound (1) with a compound (3) under the effect of an alkaline matter; performing a bromination reaction of the compound (3) to obtain a compound (4); condensing the compound (4) and 4-amino-1,2,4-triazole (5); and performing diazotization to remove the amino to obtain letrozole (6). According to the method provided by the invention, the route is simple; the cheap and easily available p-chlorobenzonitrile and p-tolunitrile are adopted as starting raw materials, and the target product letrozole is obtained through 3 steps of reactions in total; and the preparation method has the advantages of mild reaction conditions, simple and convenient operation, high yield, good chemical selectivity and low production cost, is suitable for industrial production and brings relatively great practical application value and social economic benefits.