10466-37-2

Usage

Uses

Used in Pharmaceutical Industry:
4,4'-(1-METHYLENE) BIS-BENZONITRILE is used as a reagent for the synthesis of various organic compounds, contributing to the development of new pharmaceutical products.
Used in Agrochemical Industry:
In the agrochemical industry, 4,4'-(1-METHYLENE) BIS-BENZONITRILE serves as a reagent for the synthesis of compounds that can be used in the development of agrochemicals, such as pesticides and herbicides.
Used in Polymer Industry:
4,4'-(1-METHYLENE) BIS-BENZONITRILE is used as a stabilizer in the polymer industry, enhancing the stability and performance of various polymer materials.
Used in Specialty Chemicals and Dyes Production:
Due to its unique chemical structure and reactivity, 4,4'-(1-METHYLENE) BIS-BENZONITRILE has potential applications in the production of specialty chemicals and dyes, contributing to the development of new products with specific properties and applications.
Overall, 4,4'-(1-METHYLENE) BIS-BENZONITRILE plays a crucial role in various chemical processes and has diverse industrial applications across different sectors.

Upstream product

• 101-77-9 4,4'-diamino diphenyl methane 
• 112809-51-5 letrozol 
• 1941-86-2 bis(4-bromophenyl)methane 
• 100-44-7 benzyl chloride 
• 14568-85-5 bis-(4-acetoxymethyl-phenyl)-methane 
• 67-37-8 4,4'-methylenedibenzaldehyde 
• 14568-86-6 bis<4-(hydroxymethyl)phenyl>methane 
• 14568-83-3 4,4'-bis(chloromethyl)diphenylmethane 
• 1194-02-1 4-fluorobenzonitrile 
• 104-85-8 para-methylbenzonitrile 
• 544-92-3 copper(I) cyanide 
• 51473-27-9 4,4'-methanediyl-di-benzaldehyde-dioxime 
• 75-09-2 dichloromethane 
• 623-00-7 4-bromobenzenecarbonitrile 

Downstream Products

• 31948-16-0 bis(4-benzoylphenyl)methane 
• 790-83-0 4,4'-methylenedibenzoic acid 
• 4934-35-4 4,4'-di-(aminomethyl)-diphenylmethane 
• 69545-39-7 4,4'-dicyanodiphenylbromomethane 
• 119597-24-9 bis-[4-(α-dehydro-benzhydryl)-phenyl]-methane 
• 103388-91-6 bis<(α,α-diphenyl-α-chloro)-p-tolyl>methane 
• 103389-01-1 bis-[4-(α-hydroxy-benzhydryl)-phenyl]-methane 
• 67-37-8 4,4'-methylenedibenzaldehyde 
• 1334667-31-0 1-(4,4'-dicyanodiphenylmethyl)-4-phenyl-1H-1,2,3-triazole 
• 1334667-32-1 1-(4,4'-dicyanodiphenylmethyl)-4-(phenoxymethyl)-1H-1,2,3-triazole 
• 1334667-33-2 1-(4,4'-dicyanodiphenylmethyl)-4-((4-chlorophenoxy)methyl)-1H-1,2,3-triazole 
• 1334667-34-3 1-(4,4'-dicyanodiphenylmethyl)-4-((4-cyanophenoxy)methyl)-1H-1,2,3-triazole 
• 1334667-35-4 1-(4,4'-dicyanodiphenylmethyl)-4-((4-nitrophenoxy)methyl)-1H-1,2,3-triazole 
• 1334667-36-5 1-(4,4'-dicyanodiphenylmethyl)-4-((p-tolyloxy)methyl)-1H-1,2,3-triazole 

Relevant academic research and scientific papers

A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions

A general electrochemical system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et3N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an alcohol as a co-solvent.

Dual Nickel- And Photoredox-Catalyzed Reductive Cross-Coupling of Aryl Halides with Dichloromethane via a Radical Process

The first catalytic strategy to harness a new chloromethane radical from dichloromethane under dual Ni/photoredox catalytic conditions has been developed. Compared with traditional two-electron reductive process associated with metallic reductants, this method via a single-electron approach can proceed under exceptionally mild conditions (visible light, ambient temperature, no strong base) and exhibits complementary reactivity patterns. It affords a broad scope of many functional groups, including alkenyl, which suffers cyclopropanation in previous routes. The diarylmethane-d2 compounds can be readily available with this transformation.

Construction of Di(hetero)arylmethanes Through Pd-Catalyzed Direct Dehydroxylative Cross-Coupling of Benzylic Alcohols and Aryl Boronic Acids Mediated by Sulfuryl Fluoride (SO2F2)

A practical Pd-catalyzed direct dehydroxylative coupling of (hetero)benzylic alcohols with (hetero)arylboronic acids for the constructions of di(hetero)arylmethane derivatives under SO2F2 was described. This new method provided a strategically distinct approach to di(hetero)arylmethane derivatives from readily available and abundant benzylic alcohols under mild condition.

Preparation method of letrozole

The invention provides a preparation method of letrozole (6). The preparation method comprises the following steps: reacting a compound (1) with a compound (3) under the effect of an alkaline matter; performing a bromination reaction of the compound (3) to obtain a compound (4); condensing the compound (4) and 4-amino-1,2,4-triazole (5); and performing diazotization to remove the amino to obtain letrozole (6). According to the method provided by the invention, the route is simple; the cheap and easily available p-chlorobenzonitrile and p-tolunitrile are adopted as starting raw materials, and the target product letrozole is obtained through 3 steps of reactions in total; and the preparation method has the advantages of mild reaction conditions, simple and convenient operation, high yield, good chemical selectivity and low production cost, is suitable for industrial production and brings relatively great practical application value and social economic benefits.

Efficient synthesis of diarylmethane derivatives by PdCl2 catalyzed cross-coupling reactions of benzyl chlorides with aryl boronic acids in aqueous medium

The research provides a simple and efficient method for preparing diarylmethane derivatives using the cross-coupling reaction of benzyl chlorides and aryl boronic acids catalyzed by palladium chloride in DMF aqueous solution without additional ligand.

Synthesis and structure-activity relationship of 1- and 2-substituted-1,2,3-triazole letrozole-based analogues as aromatase inhibitors

A series of bis- and mono-benzonitrile or phenyl analogues of letrozole 1, bearing (1,2,3 and 1,2,5)-triazole or imidazole, were synthesized and screened for their anti-aromatase activities. The unsubstituted 1,2,3-triazole 10a derivative displayed inhibitory activity comparable with that of the aromatase inhibitor, letrozole 1. Compound 10a, bearing a 1,2,3-triazole, is also 10000-times more tightly binding than the corresponding analogue 25 bearing a 1,2,5-triazole, which confirms the importance of a nitrogen atom at position 3 or 4 of the 5-membered ring needed for high activity. The effect on human epithelial adrenocortical carcinoma cell line (H295R) proliferation was also evaluated. The compound 10j (IC50 = 4.64 μM), a letrozole 1 analogue bearing para-cyanophenoxymethylene-1,2,3-triazole decreased proliferation rates of H295R cells by 76 and 99% in 24 and 72 h respectively. Computer calculations, using quantum ab initio structures, suggest a possible correlation between anti-aromatase activity and the distance between the nitrogen in position 3 or 4 of triazole nitrogen and the cyano group nitrogen.

Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents

A series of bis-benzimidazole diamidine compounds containing different central linkers has been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Seven compounds have shown potent antibacterial activities. The anti-MRSA and anti-VRE activities of compound 1h were more potent than that of the lead compound 1a and vancomycin.

A METHOD OF MANUFACTURE OF LETROZOLE

A novel and convenient method of manufacture of letrozole of formula (I) is described. Letrozole is an aromatase inhibitor drug used in the treatment of postmenopausal breast cancer.