104858-59-5

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 89861-27-8 C₁₀H₁₇O₆P^(2-)*2K⁽¹⁺⁾ 
• 13148-05-5 ethyl 3-oxo-4-(triphenylphosphoranylidene)butanoate 
• 123-11-5 4-methoxy-benzaldehyde 
• 623-73-4 diazoacetic acid ethyl ester 
• 24680-50-0 4-methoxy-trans-cinnamaldehyde 
• 141-78-6 ethyl acetate 
• 682770-51-0 ethyl 5-hydroxy-5-(4-methoxyphenyl)-3-oxopentanoate 
• 141-97-9 ethyl acetoacetate 
• 848900-78-7 5-(2-Chloro-acetoxy)-5-(4-methoxy-phenyl)-3-oxo-pentanoic acid ethyl ester 

Downstream Products

• 1314236-55-9 (1S,2R,3R)-ethyl 2-formyl-3-(furan-2-yl)-5-hydroxy-4'-methoxy-1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-carboxylate 
• 1383577-10-3 (E)-ethyl 5-(2-(benzyloxy)-2-oxoethyl)-2-(4-methoxystyryl)-4,5-dihydrofuran-3-carboxylate 
• 1383577-09-0 (E)-ethyl 5-(2-ethoxy-2-oxoethyl)-2-(4-methoxystyryl)-4,5-dihydrofuran-3-carboxylate 
• 1346635-71-9 (S,E)-ethyl 3-(4-methoxystyryl)-2H-azirine-2-carboxylate 
• 1346635-57-1 (4E)-ethyl 3-{([{3,5-bis(trifluoromethyl)phenyl}sulfonyl]oxy)imino}-5-(4-methoxyphenyl)pent-4-enoate 
• 89861-42-7 trans-4-(4-methoxyphenyl)-3-butenoic acid ethyl ester 

Relevant academic research and scientific papers

Preparation of γ,δ-unsaturated-β-ketoesters: Lewis acid-catalysed C[sbnd]H insertion of ethyl diazoacetate into α,β-unsaturated aldehydes

The synthesis of γ,δ-unsaturated-β-keto esters was achieved by the Lewis acid-catalysed direct C[sbnd]H insertion of an α-diazoester into various α,β-substituted-unsaturated aldehydes. C[sbnd]H insertion of ethyl diazoacetate into alkyl- and aryl-substituted α,β-unsaturated aldehydes was performed under mild conditions to afford the corresponding γ,δ-unsaturated-β-keto esters in moderate to high yields as a mixture of keto/enol tautomers.

PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME

The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis.

A general organocatalyzed Michael-Michael cascade reaction generates functionalized cyclohexenes

Although β-dicarbonyl compounds are regularly employed as Michael donors, intermediates arising from the Michael addition of unsaturated β-ketoesters to α,β-unsaturated aldehydes are susceptible to multiple subsequent reaction pathways. We designed cyclic

Candida Rugosa lipase-catalyzed kinetic resolution of β-hydroxy- β-arylpropionates and δ-hydroxy-δ-aryl-β-oxo-pentanoates

A simple and convenient method was reported for the preparation of optically active β-hydroxy-β-arylpropionates, δ-hydroxy-δ- aryl-β-oxo-pentanoates and their butyryl derivatives via CRL-catalyzed hydrolysis. The optically active products are potential precursors of some chiral pharmaceuticals and natural products.

ANIONIC ACTIVATION OF STABILIZED YLIDES. A HIGHLY Z-STEREOSELECTIVE WITTIG REACTION OF (3-ETHOXYCARBONYL-2-OXOPROPYLIDENE)TRIPHENYLPHOSPHORANE WITH ALIPHATIC ALDEHYDES

Reaction of stabilized ylide 1 with carbonyl partners can be promoted via anionic activation of the ylide; the presence of charge is responsible for the high Z-selectivity in the direct formation of conjugated enones.

RHODIUM(II) ACETATE-CATALYZED REACTION OF ETHYL 2-DIAZO-3-OXOPENT-4-ENOATES: SIMPLE ROUTES TO 4-ARYL-2-HYDROXY-1-NAPHTHOATES AND β,γ-UNSATURATED ESTERS. THE DIANION OF ETHYL 4-(DIETHYLPHOSPHONO)ACETOACETATE AS A PROPIONATE EQUIVALENT

Rhodium(II) acetate-catalyzed decomposition of ethyl 2-diazo-3-oxopent-4-enoates results in the formation of either 4-aryl-2-hydroxy-naphthoates or β,γ-unsaturated esters.In the latter transformation, the dianion of 4-(diethylphosphono)acetoacetate functi

ETHYL 4-DIPHENYLPHOSPHINOYL-3-OXOBUTANOATE: A CONVENIENT REAGENT FOR THE SYNTHESIS OF γ,δ-UNSATURATED Β-KETOESTERS

Aldehydes and ketones can be converted into γ,δ-unsaturated-β-ketoesters by reaction with the dianion from phosphine oxide 1.