104892-58-2

Upstream product

• 799291-47-7 1-(3,4,5-tribromo-phenyl)-ethanol 
• 64-19-7 acetic acid 
• 99-90-1 para-bromoacetophenone 
• 22589-50-0 4-amino-3,5-dibromo-acetophenone 

Downstream Products

• 861343-32-0 1-(3,4,5-tribromo-2-nitro-phenyl)-ethanone 
• 116772-89-5 C₈H₃⁽²⁾H₇O 
• 87976-31-6 C₇H₃⁽²⁾H₃O₂ 
• 618-74-6 3,4,5-tribromobenzoic acid 

Relevant academic research and scientific papers

Remote electronic effects in the rhodium-catalyzed nucleophilic ring opening of oxabenzonorbornadienes.

We report the application of our rhodium-catalyzed nucleophilic ring-opening methodology to unsymmetrically arene-substituted oxabenzonorbornadienes. The regioselectivity of the ring opening was investigated using a variety of nucleophiles that led to a broad selection of dihydronaphthalene products. It was found that good to excellent regioselectivities are obtained using strongly pi-donating substituents, whereas sigma-donating and electron-withdrawing functionalities have a minimal effect. Post ring-opening manipulations of functional groups in the dihydronaphthalene products were shown to give efficient access to mono- and diamine tetrahydronaphthalene building blocks.

PREPARATION OF DEUTERIATED 1-PHENYLETHANOLS BY REDUCTIVE DEHALOGENATION OF THE CORRESPONDING HALOGENOACETOPHENONES WITH RANEY ALLOYS IN AN ALKALINE DEUTERIUM OXIDE SOLUTION

Deuteriated 1-phenylethanols were prepared by reductive dehalogenation of the corresponding halogenoacetophenones with Raney Ni-Al and Cu-Al alloys in 5percent NaOD-D2O solution.It was found that the Ni-Al alloy introduced greater than expected numbers of deuterium atoms in the phenyl ring, but the expected deuteriated 1-phenylethanols were obtained in high yield and in high isotopic purity when Raney Cu-Al alloy was used.