22589-50-0

Usage

Uses

Used in Pharmaceutical Industry:
4'-Amino-3',5'-dibromoacetophenone is used as an intermediate for the synthesis of new drugs and medications, contributing to the development of innovative treatments and therapies.
Used in Chemical Industry:
In the chemical industry, 4'-Amino-3',5'-dibromoacetophenone serves as a reagent in organic synthesis, facilitating the creation of a variety of chemical compounds.
Used in Research and Development:
4'-AMINO-3',5'-DIBROMOACETOPHENONE is utilized in research and development settings, where it aids in the exploration of new chemical reactions and the discovery of novel applications.
Used in Specialty Chemicals Manufacturing:
4'-Amino-3',5'-dibromoacetophenone is also employed in the manufacturing process of specialty chemicals, where its unique properties are leveraged to produce high-value products.

Upstream product

• 7726-95-6 bromine 
• 99-92-3 p-aminobenzophenone 
• 64-19-7 acetic acid 
• 107-21-1 ethylene glycol 

Downstream Products

• 14401-73-1 3,5-dibromoacetophenone 
• 6311-60-0 3,5-dibromonitrobenzene 
• 84483-37-4 2,6-dibromo-4,N-dinitro-aniline 
• 63561-47-7 N-(4-acetyl-2,6-dibromo-phenyl)-diacetamide 
• 60677-24-9 3,5-dibromo-4-methoxycarbonylaminoacetophenone 
• 97760-80-0 4'-amino-3',5'-dicyano-acetophenone 
• 501422-70-4 4-acetyl-2,6-di(phenyl-d5)aniline 
• 1027295-83-5 1-[2'-(2,4-Dichloro-phenylsulfanylamino)-[1,1';3',1'']terphenyl-5'-yl]-ethanone 
• 203051-46-1 1-[2'-(4-Nitro-phenylsulfanylamino)-[1,1';3',1'']terphenyl-5'-yl]-ethanone 
• 1027910-12-8 1-[4,4''-Dichloro-2'-(2,4-dichloro-phenylsulfanylamino)-[1,1';3',1'']terphenyl-5'-yl]-ethanone 
• 1026413-38-6 N-[(2,4-dichlorophenyl)thio]-4-acetyl-2,4-di(phenyl-d5)aniline 
• 56340-89-7 4'-amino-2-tert-butylamino-3',5'-dicyano-acetophenone 
• 56340-95-5 4'-amino-3',5'-dicyano-2-tert-pentylamino-acetophenone 
• 94850-96-1 1-(4'-Amino-3',5'-dicyano-phenyl)-2-isopropylamino-ethanol 

Relevant academic research and scientific papers

Phenylethanolamine β receptor agonist synthetic method

The invention discloses a phenylethanolamine β receptor agonist synthetic method, comprises the following steps: S1: the 4 - amino acetophenone dissolved in an organic solvent, with the electrophilic reagent occurs on the benzene ring substituted halogenated reaction, generating [...] intermediate; [...] intermediates in organic solvent or in water, under the catalysis of the metal catalyst with the cyanide reagent undergo nucleophilic substitution reaction, generating phenyl ketone intermediate; S2: phenyl ketone intermediates in organic solvent, with the copper bromide generating carbonyl α bromo reaction to produce α - bromoacetophenone intermediates; S3: α - bromoacetophenone intermediates in organic solvent with tert-butyl amine or isopropylamine reaction intermediates acetophenone amines; S4: acetophenone amine intermediates in organic solvent, with the reduction hydrogenation reagent react to generate the phenylethanolamine β receptor agonists; synthetic method of this invention a simple and highly efficient and cheap and easy to obtain, atom utilization is high, the synthetic product chemical purity is greater than 99%, to meet the detection requirements of the food safety.

A new chemoselective synthesis of brombuterol

A practical method for the synthesis of brombuterol [1-(4-amino-3,5- dibromophenyl)-2-(tert-butylamino)ethanol] in high overall yield is described starting from 4′-aminoacetophenone using a new chemoselective route. Georg Thieme Verlag Stuttgart.