1049-17-8Relevant academic research and scientific papers
An Electrochemical Way to Generate Amphiphiles from Hydrazones for the Synthesis of 1,2,4-Triazole Scaffold Cyclic Compounds
Li, Wangyu,Liang, Xiao,Pan, Yuanjiang,Wang, Dungai,Xiong, Mingteng,Zhu, Heping
, (2022/02/02)
An electro-oxidative cyclization pathway in which hydrazones are selected as starting materials to generate amphiphiles by reacting with benzylamines and benzamides was reported. This strategy successfully prepared a series of 1,2,4-triazoles in satisfact
An electrochemical multicomponent [3 + 1 + 1] annulations to synthesize polysubstituted 1,2,4-triazoles
Zhao, Zhiheng,He, Yonghui,Li, Ming,Xu, Jiazhe,Li, Xiangguang,Zhang, Lizhu,Gu, Lijun
, (2021/04/12)
An electrochemical multicomponent [3 + 1 + 1] annulation used for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed under transition-metal-, acid-, base- and external-oxidant-free conditions. In an undivided cell, a variety of hydrazones and aldehydes smoothly participate in this transformation to furnish a range of substituted 1,2,4-triazoles. The reaction constitutes a new transformation from hydrazones, aldehydes and NH4OAc into 1,2,4-triazoles, providing a unifying, simple and environmentally friendly approach to the currently available methods.
TBHP/TBAI–Mediated simple and efficient synthesis of 3,5-disubstituted and 1,3,5-trisubstituted 1H-1,2,4-triazoles via oxidative decarbonylation of aromatic aldehydes and testing for antibacterial activities
Agisho, Habtamu Abebe,Esatu, Habdolo,Hairat, Suboot,Zaki, Mehvash
supporting information, (2020/05/19)
The author has developed a simple, efficient and eco–friendly convenient general method for synthesis of 3,5–disubstituted–1,2,4–triazoles and 1,3,5–trisubstituted–1,2,4–triazoles from 3–monosubstituted–1,2,4–triazoles and 1,3–disubstituted–1,2,4–triazoles respectively using tetrabutylammonium iodide (TBAI) as catalyst and TBHP as oxidant under mid reaction conditions. This method provides structurally diverse 3,5–disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles in good to excellent yields. 3,5–Disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles derivatives are biologically and pharmaceutically active molecules, and therefore, this protocol could be of wide applications in medicinal chemistry and organic chemistry.
Direct Access to 1,3,5-Trisubstituted 1 H -1,2,4-Triazoles from N -Phenylbenzamidines via Copper-Catalyzed Diamination of Aryl Nitriles
Zhang, Lutao,Tang, Dong,Gao, Jing,Wang, Jing,Wu, Ping,Meng, Xu,Chen, Baohua
, p. 3924 - 3930 (2016/11/11)
A copper-catalyzed formation of C-N/N-N bonds using N-phenylbenzamidines with aryl nitriles has been developed and affords a route to 1,3,5-trisubstituted 1H-1,2,4-triazoles in moderate to excellent yields. The method is operationally simple and environme
OXAZOLONES. PART VI. REACTION OF 5(4H)-OXAZOLONES WITH NITRILE IMINES: SYNTHESIS OF 1H-1,2,4-TRIAZOLES THROUGH CYCLOADDITION
Gelmi, Maria Luisa,Pocar, Donato,Riva, Raul
, p. 315 - 320 (2007/10/02)
5(4H)-Oxazolones (1) react as dipolarophiles in cycloadditions with nitrile imines generated from tetrazoles (2) in refluxing anisole affording two 1H-1,2,4-triazole derivatives (3) and diarylethylenes (4).
1,3-DIPOLAR CYCLOADDITIONS OF 1-(N-ARYLIDENE)AMINO-1,2,3-TRIAZOLES WITH DIPHENYLNITRILIMINE
Bojilova, Anka,Rodios, Nestor A.,Alexandrou, Nicholas E.
, p. 3233 - 3238 (2007/10/02)
1-(N-arylidene)amino-1,2,3-triazoles (1) and (9) react with diphenylnitrilimine (2) to give the corresponding 1,2,3- and 1,2,4-triazoles (3) and (4) as well as 1- and 2-benzohydrazonoyl-1,2,3-triazoles (5), (10) and (6) and (11) respectively.These products are formed assuming an initial cycloadduct, (7), which upon elimination of the triazole ring gives compounds (3) and (4).Further reaction of the triazole system with (2) gives the hydrazone derivatives (5), (6), (10), and (11).The reaction is also studied on the basis of frontier molecular orbitals (FMO) of the reacting species.
