21863-32-1

Basic information

• Product Name: Quinoline, 1,2,3,4-tetrahydro-1-(phenylmethyl)-
• Synonyms: N-benzyltetrahydroquinoline;1-Benzyl-1,2,3,4-tetrahydro-chinolin;N-benzyl-1,2,3,4-tetrahydroquinoline;1-benzyl-1,2,3,4-tetrahydroquinoline;N-benzyl-1,2,3,4-tetrahydroquinaldine
• CAS NO: 21863-32-1
• Molecular Formula: C16H17N
• Molecular Weight: 223.318
• Mol File: 21863-32-1.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: Quinoline, 1,2,3,4-tetrahydro-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 1,2,3,4-tetrahydro-1-(phenylmethyl)-(21863-32-1)
• EPA Substance Registry System: Quinoline, 1,2,3,4-tetrahydro-1-(phenylmethyl)-(21863-32-1)

Safety Data

• Hazardous Substances Data: 21863-32-1(Hazardous Substances Data)

Upstream product

• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 100-52-7 benzaldehyde 
• 100-39-0 benzyl bromide 
• 91-63-4 2-methylquinoline 
• 1780-19-4 1,2,3,4-tetrahydro-2-methylquinoline 
• 18655-51-1 2-(3-Aminopropyl)-1-methoxybenzene 
• 135-02-4 ortho-anisaldehyde 
• 3193-62-2 N-benzyl-1-phenylethylamine 
• 24393-54-2 ethyl 3-(2-methoxyphenyl)prop-2-enoate 
• 70311-27-2 2-methoxybenzenepropanoic acid ethyl ester 
• 10493-37-5 3-(2-methoxyphenyl)propan-1-ol 
• 146253-19-2 3-(2-methoxyphenyl)propyl methanesulfonate 
• 101581-87-7 N-phenylmethyl-3-(2-methoxyphenyl)propylamine 
• 100-47-0 benzonitrile 

Downstream Products

• 1438900-67-4 1,1'-dibenzyl-1,1',2,2',3,3',4,4'-octahydro-6,6'-biquinoline 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Reusable Co-nanoparticles for general and selectiveN-alkylation of amines and ammonia with alcohols

A general cobalt-catalyzedN-alkylation of amines with alcohols by borrowing hydrogen methodology to prepare different kinds of amines is reported. The optimal catalyst for this transformation is prepared by pyrolysis of a specific templated material, which is generatedin situby mixing cobalt salts, nitrogen ligands and colloidal silica, and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary, and tertiary amines includingN-methylamines and selected drug molecules were conveniently prepared starting from inexpensive and easily accessible alcohols and amines or ammonia.

Manganese(III) Porphyrin-Catalyzed Dehydrogenation of Alcohols to form Imines, Tertiary Amines and Quinolines

Manganese(III) porphyrin chloride complexes have been developed for the first time as catalysts for the acceptorless dehydrogenative coupling of alcohols and amines. The reaction has been applied to the direct synthesis of imines, tertiary amines and quinolines where only hydrogen gas and/or water are formed as the by-product(s). The mechanism is believed to involve the formation of a manganese(III) alkoxide complex which degrades into the aldehyde and a manganese(III) hydride species. The latter reacts with the alcohol to form hydrogen gas and thereby regenerates the alkoxide complex.

Radical-mediated direct C-H amination of arenes with secondary amines

Aryl dialkyl amines, valuable subunits of a wide range of effect chemicals, are accessed by intramolecular amination of aromatic C-H bonds employing UV photolysis of N-chloroamines. The reactions show good functional group tolerance and allow access to a range of fused and bridged polycyclic structures. The homogeneous reaction conditions allow for the one-pot conversion of secondary amines to their arylated derivatives. Experimental and theoretical evidence supports the involvement of electrophilic aminium radicals which react via direct ortho-attack on the arene.