105191-14-8

Basic information

• Product Name: ethyl 5-cyano-1-benzothiophene-2-carboxylate
• Synonyms: Ethyl-5-cyan-1-benzothiophen-2-carboxylat
• CAS NO: 105191-14-8
• Molecular Formula: C₁₂H₉NO₂S
• Molecular Weight: 231.2704
• Mol File: 105191-14-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 392.279°C at 760 mmHg
• Flash Point: 191.044°C
• Density: 1.31g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: ethyl 5-cyano-1-benzothiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-cyano-1-benzothiophene-2-carboxylate(105191-14-8)
• EPA Substance Registry System: ethyl 5-cyano-1-benzothiophene-2-carboxylate(105191-14-8)

Safety Data

• Hazardous Substances Data: 105191-14-8(Hazardous Substances Data)

Upstream product

• 872-50-4 1-methyl-pyrrolidin-2-one 
• 7312-10-9 5-bromo-1-benzothiophene-2-carboxylic acid 
• 13771-68-1 5-bromobenzo[b]thiophene-2-carboxylic acid ethyl ester 
• 105191-40-0 4-chloro-3-(hydroxymethyl)benzonitrile 
• 89951-56-4 4-chloro-5-hydroxymethyl aniline 
• 25785-09-5 ethyl 5-nitro-2-benzo[b]thiophenecarboxylate 
• 25785-10-8 ethyl 5-amino-1-benzothiophene-2-carboxylate 
• 544-92-3 copper(I) cyanide 
• 68-11-1 mercaptoacetic acid 
• 105191-41-1 4-chloro-3-formylbenzonitrile 
• 80866-80-4 2-chloro-5-nitrobenzyl alcohol 

Downstream Products

• 105191-50-2 <(5-Cyan-1,1-dioxobenzothien-2-yl)methyl>triphenylphosphoniumbromid 
• 105191-33-1 <(5-Cyanbenzothien-2-yl)methyl>triphenylphosphoniumbromid 
• 105191-43-3 2-(Brommethyl)benzothiophen-5-carbonitril 
• 1026500-69-5 {4-[(5-mercaptocarbonimidoyl-benzo[b]thiophene-2-carbonyl)-amino]-phenoxy}-acetic acid tert-butyl ester 
• 1026868-22-3 {4-[(5-methylsulfanylcarbonimidoyl-benzo[b]thiophene-2-carbonyl)-amino]-phenoxy}-acetic acid tert-butyl ester 
• 174774-80-2 t-butyl 4-[(5-cyanobenzo [b]thien-2-yl)carbonylamino]phenoxyacetate 
• 154650-76-7 5-cyanobenzo[b]thiophene-2-carboxylic acid 

Relevant articles and documents

Aromatic amidine derivatives useful as selective thrombin inhibitors

The present invention relates to a novel thrombin inhibitor which is effective even when orally administered. More specifically, the present invention relates to an aromatic amidine derivative represented by formula (I) and the salts thereof, which show potent selective inhibitory activity for thrombin in which (a), R, R1, R2, R3, A, W, Y and n are defined as described in the specification.

AROMATIC AMIDINE DERIVATIVES AND SALTS THEREOF

An anticoagulant agent which comprises, as an active ingredient, an aromatic amidine derivative represented by the following general formula (1) or a salt thereof: STR1 wherein the group represented by STR2 is a group selected from indolyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, naphthyl, tetrahydronaphthyl and indanyl; X is a single bond, an oxygen atom, a sulfur atom or a carbonyl group; and Y is a saturated or unsaturated 5-or 6-membered heterocyclic moiety or cyclic hydrocarbon moiety optionally having a substituent group, an amino group optionally having a substituent group or an aminoalkyl group optionally having a substituent group.The inventive compound has a high anticoagulant capacity based on its excellent FXa inhibition activity.