105376-46-3

Upstream product

• 67-56-1 methanol 
• 612-41-9 2-nitrocinnamic acid 
• 103-26-4 Methyl cinnamate 
• 552-89-6 2-nitro-benzaldehyde 
• 110-89-4 piperidine 
• 105-45-3 acetoacetic acid methyl ester 
• 612-41-9 2-nitrocinnamic acid 
• 96-32-2 bromoacetic acid methyl ester 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 292638-85-8 acrylic acid methyl ester 
• 609-73-4 o-nitroiodobenzene 
• 577-19-5 2-nitrophenyl bromide 
• 1466-88-2 2-nitrocinnamaldehyde 
• 5927-18-4 trimethyl phosphonoacetate 

Downstream Products

• 88939-75-7 methyl β-(o-aminophenyl)acrylate 
• 2001-33-4 o-nitrocinnamamide 
• 612-41-9 2-nitrocinnamic acid 
• 1202-04-6 indole-2-carboxylic acid methyl ester 
• 105404-33-9 (±)-methyl 2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate 
• 59-31-4 2-quinolone 
• 88939-75-7 methyl (2E)-3-(2-aminophenyl)propenoate 
• 1664-65-9 3-(2-nitrophenyl)propionic acid methyl ester 
• 1493774-32-5 4-bromo-2-nitro-benzenepropanoic acid methyl ester 
• 1493774-03-0 C₁₀H₁₃NO₃ 
• 36193-36-9 (±)-rhazinilam 
• 138386-58-0 (E)-methyl 3-[2-(triphenylphosphoranylidenamino)phenyl]-propenoate 
• 1076689-73-0 4-(N-benzylacetamino)-3-(4-biphenylyl)-2-[N-(5-aminopentyl)-N-methylamino]-3,4-dihydroquinazoline 
• 1076689-75-2 2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline 

Relevant academic research and scientific papers

In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells

As a result of our continuous research, new 3,4-dihydroquinazoline derivative containing ureido group, KCP10043F was synthesized and evaluated for T-type Ca2+channel (Cav3.1) blockade, cytotoxicity, and cell cycle arrest against huma

Novel cyclodextrin-modified h-BN@Pd(II) nanomaterial: An efficient and recoverable catalyst for ligand-free C-C cross-coupling reactions in water

An environmentally friendly palladium(II) catalyst supported on cyclodextrin-modified h-BN was successfully prepared. The catalyst was characterized by FT-IR, SEM, TG, XRD and XPS, and the loading level of Pd in h-BN@β-CD@Pd(II) was measured to be 0.088?mmol g?1 by ICP. It exhibits excellent catalytic activity for the Suzuki and Heck reactions in water, and can be easily separated and consecutively reused for at least nine times. In addition, a series of pharmacologically interesting products were successfully synthesized using this catalyst to demonstrate its potential applications in pharmaceutical industries. Above all, this work opens up an interesting and attractive avenue for the use of cyclodextrin-functionalized h-BN as an efficient support for hydrophilic heterogeneous catalysts.

Preparation method of 3-(2-aminophenyl)-2-acrylate

The present invention relates to the field of pharmaceutical preparation technology, in particular a 3-(2-aminophenyl)-2-acrylate preparation method, comprising the following steps: 1) under the action of a base, o-nitrobenzaldehyde and malonate derivativ

Photoinduced Regioselective Olefination of Arenes at Proximal and Distal Sites

The Fujiwara-Moritani reaction has had a profound contribution in the emergence of contemporary C-H activation protocols. Despite the applicability of the traditional approach in different fields, the associated reactivity and regioselectivity issues had

One-Pot, Three-Step Synthesis of Benzoxazinones via Use of the Bpin Group as a Masked Nucleophile

The utilization of the Bpin group as a pronucleophile to facilitate the assembly of cyclic carbamates has been achieved. This one-pot process involves an initial copper-catalyzed borylation, a subsequent C-B bond oxidation to generate the reactive alcohol

Enantioselective Rauhut–Currier Reaction with β-Substituted Acrylamides Catalyzed by N-Heterocyclic Carbenes

β-Substituted acrylamides have low electrophilicity and are yet to be exploited in the enantioselective Rauhut–Currier reaction. By exploiting electron-withdrawing protection of the amide and moderate nucleophilicity N-heterocyclic carbenes, such substrates have been converted to enantioenriched quinolones. The reaction proceeds with complete diastereoselectivity, good yield, and modest enantioselectivity. Derivatizations are reported, as are computational studies, supporting decreased amide bond character with electron-withdrawing protection of the nitrogen.

Pd/Cu-free Heck and Sonogashira coupling reactions applying cobalt nanoparticles supported on multifunctional porous organic hybrid

A new heterogeneous cobalt catalyst has been synthesized by immobilizing Co species onto a nitrogen-rich porous organic polymer (Co@imine-POP). The heterogeneous catalyst synthesized was efficient in Heck and Sonogashira cross-coupling reactions in green media under mild reaction conditions without inert air and phase transfer agents. This phosphine-, copper-, and palladium-free catalyst was stable under the reaction conditions and could be reused for at least eight successive runs without a discernible decrease in its catalytic activity.

Access to [2,1]benzothiazine s,s-dioxides from β-substituted o-nitrostyrenes and sulfur

[2,1]Benzothiazine S,S-dioxides 2 were synthesized by simply heating o-nitrostyrenes with elemental sulfur in 3- picoline with complete atom economy. This reaction was found to occur without any added catalyst and consist of a cascade of reduction of the

Phosphetane oxides as redox cycling catalysts in the catalytic wittig reaction at room temperature

Recently, phosphorus redox cycling has gained significant importance for a number of transformations originally requiring the use of stoichiometric amounts of phosphorus reagents. While these methodologies have several benefits, high catalyst loadings (≥10 mol percent) and harsh reaction conditions (T ≥ 100 °C) often limit their versatility and applicability. Herein, we report differently substituted phosphetane oxides as efficient catalysts for the catalytic Wittig reaction. The phosphetane scaffold is easy to modify, and a number of catalysts can be obtained in a simple two-step synthesis. The activity in the Wittig reaction significantly surpasses previously reported phospholane-based catalysts and the reaction can be conducted with catalyst loadings as low as 1.0 mol percent even at room temperature. Furthermore, a Br?nsted acid additive is no longer required to achieve high yields at these mild conditions. A methyl-substituted phosphetane oxide was employed to synthesize 25 different alkenes with yields of up to 97percent. The methodology has a good functional group tolerance and the reaction can be performed starting with alkyl chlorides, bromides, or iodides. Additionally, it was possible to use poly(methylhydrosiloxane) as the terminal reductant in the catalytic Wittig reaction employing 2-MeTHF as a renewable solvent. The intermediates of the Wittig reaction were analyzed by 31P NMR spectroscopy, and in situ NMR experiments confirmed phosphane oxide as the resting state of the catalyst. Further kinetic investigations revealed a striking influence of the base on the rate of phosphane oxide reduction.

Bis-quinoline-2-carboxylic acid Copper Salt as an Efficient Catalyst for Synthesis of Aryl Olefins by Heck Reaction

Abstract: A bis-quinoline-2-carboxylic acid copper salt as a single crystal was prepared and characterized by X-ray single crystal analysis. The crystal as a catalyst was applied to the Mizoroki–Heck coupling reaction between arylboronic acids and α-olefins. A series of diarylethenes and aryl olefins were synthesized with good to excellent yields at room temperature. The catalytic system exhibited good functional group tolerance and low pollution. Graphic Abstract: A bis-quinoline-2-carboxylic acid copper salt as a single crystal was prepared and characterized by X-ray single crystal analysis. The crystal as a catalyst was applied to the Mizoroki–Heck coupling reaction between arylboronic acids and α-olefins[InlineMediaObject not available: see fulltext.].