10540-32-6

Basic information

• Product Name: 1-Fluoro-4-(3-nitrophenyl)benzene
• Synonyms: 1-Fluoro-4-(3-nitrophenyl)benzene
• CAS NO: 10540-32-6
• Molecular Formula: C₁₂H₈FNO₂
• Molecular Weight: 217.1958232
• Mol File: 10540-32-6.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Fluoro-4-(3-nitrophenyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Fluoro-4-(3-nitrophenyl)benzene(10540-32-6)
• EPA Substance Registry System: 1-Fluoro-4-(3-nitrophenyl)benzene(10540-32-6)

Safety Data

• Hazardous Substances Data: 10540-32-6(Hazardous Substances Data)

Usage

Compound Type

Fluorinated aromatic compound with a nitro group.

Family

Nitrobenzene family.

Usage

Building block in the synthesis of more complex organic molecules.

Industry Applications

Pharmaceutical industry, medicinal chemistry, materials science, and chemical research.

Unique Features

Its structure and properties contribute to the development of new drugs and research into their biological activity.

Upstream product

• 585-79-5 m-nitrobromobenzene 
• 19089-94-2 p-fluorophenylgermanium trichloride 
• 645-00-1 m-iodonitrobenzene 
• 25776-12-9 sodium tetrakis(4-fluorophenyl)borate 
• 121-73-3 3-Nitrochlorobenzene 
• 1765-93-1 4-fluoroboronic acid 
• 13331-27-6 m-nitrobenzene boronic acid 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 121-92-6 3-nitrobenzoic acid 
• 437-29-6 tris(4-fluorophenyl)bismuthane 
• 132993-23-8 4-fluorophenyl trifluoromethanesulfonate 
• 18312-48-6 potassium m-nitrobenzoate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1141-29-3 3'-nitro-[1,1'-biphenyl]-4-yl-amine 

Downstream Products

• 10540-45-1 3‐(4‐fluorophenyl)aniline 
• 2664-56-4 3,3'''-dinitro-p-quaterphenyl 

Relevant articles and documents

Ligand-free, atom-efficient Suzuki-Miyaura type cross-coupling reactions at room temperature

The atom-efficient cross-coupling reaction of sodium tetraarylborates with aryl iodides and bromides was reported. The reaction can be performed directly using a catalytic system composed of palladium chloride, sodium carbonate and methanol (PdCl2/Na2CO3/MeOH) under heat-free conditions at room temperature in an open air conditions. The reactions carried out in an atom-efficient way as 4 equiv of aryl halides coupled effectively with 1 equiv of sodium tetraarylborates to furnish 4 equiv of the corresponding functionalized biaryls in good to excellent yields.

Palladium-catalyzed cross-coupling reaction by means of organogermanium trichlorides

Easily accessible arylgermanium trichlorides were found to undergo palladium-catalyzed cross-coupling reactions with aryl bromides and iodides in good yields. The reaction is performed in an aqueous medium with sodium hydroxide as an activator. Some base-

Cyclodextrin-supported palladium complex: A highly active and recoverable catalyst for Suzuki–Miyaura cross-coupling reaction in aqueous medium

A water-soluble, cyclodextrin-supported palladium complex (DACH-Pd-β-CD) catalytic system was designed and synthesized, which can efficiently catalyze Suzuki–Miyaura cross-coupling reactions between aryl halides and arylboronic acid in water under mild conditions. The catalyst was successfully characterized using the methods of transmission electron microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction, thermogravimetric analysis, and Fourier transform infrared and NMR spectroscopies. Furthermore, the catalyst can be easily separated from the reaction mixture and still maintain high catalytic activity after ten cycles. No leaching of palladium into the reaction solution occurred. The advantages of green solvent (water), short reaction times (2–6?h), low catalyst loading (0.001?mol%), excellent yields (up to 99%) and reusability of the catalyst mean it will have potential applications in green chemical synthesis.

Alpha-diimine nickel metal organic ligand, porous organic polymer and application of porous organic polymer

The disclosure provides an alpha-diimine nickel metal organic ligand, a porous organic polymer and application of the porous organic polymer. The porous organic polymer has a chemical structural formula as shown in the description. The porous organic polymer can be applied to preparation of a catalyst for catalyzing a Suzuki coupling reaction, and the catalyst has high catalytic activity, low cost, low usage amount and repeated use.

Ferrocenyl palladacycles derived from unsymmetrical pincer-type ligands: Evidence of Pd(0) nanoparticle generation during the Suzuki-Miyaura reaction and applications in the direct arylation of thiazoles and isoxazoles

A new family of ferrocenyl-palladacycle complexes Pd(L1)Cl (Pd1) and Pd(L2)Cl (Pd2) were synthesized and characterized by UV-visible, IR, ESI-MS, and NMR spectral studies. The molecular structures of Pd1 and Pd2 were determined by X-ray crystallographic studies. Palladacycle catalyzed Suzuki-Miyaura cross-coupling reactions were investigated utilizing the derivatives of phenylboronic acids and substituted chlorobenzenes. Mechanistic investigation authenticated the generation of Pd(0) nanoparticles during the catalytic cycle and the nanoparticles were characterized by XPS, SEM and TEM analysis. Direct C-H arylation of thiazole and isoxazole derivatives employing these ferrocenyl-palladacycle complexes was examined. The reaction model for the arylation reaction implicating the in situ generation of Pd(0) nanoparticles was proposed.