10570-46-4

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 122-52-1 triethyl phosphite 
• 108054-54-2 diethyl (4-chlorophenyl)(hydroxy)methylphosphonate 
• 104-88-1 4-chlorobenzaldehyde 
• 110480-88-1 diethyl 1-amino(p-chlorophenyl)methylphosphonate 
• 106-39-8 bromochlorobenzene 
• 201230-82-2 carbon monoxide 
• 762-04-9 phosphonic acid diethyl ester 
• 3226-37-7 4-chlorophenyl thiocyanate 
• 78-40-0 triethyl phosphate 
• 52057-50-8 α-trimethylsiloxy-p-chlorobenzylphosphonic acid diethyl ester 

Downstream Products

• 56738-48-8 1-(4-chloro-phenyl)-2-(3,4-dimethyl-3H-thiazol-2-ylidene)-ethanone 
• 37127-97-2 4-benzyl-2-(4-chloro-phenyl)-5-methyl-4H-[1,4]thiazin-3-one 
• 37390-86-6 3-benzyl-2-[(4-chloro-phenyl)-diethoxyphosphoryloxy-methyl]-4-methyl-thiazolium; chloride 
• 56738-47-7 1-(4-chloro-phenyl)-2-(3-methyl-3H-thiazol-2-ylidene)-ethanone 
• 30015-73-7 4-benzyl-2-(4-chloro-phenyl)-4H-benzo[1,4]thiazin-3-one 
• 57180-06-0 phosphoric acid (N'-benzoyl-N-ethyl-hydrazinocarbonyl)-(4-chloro-phenyl)-methyl ester diethyl ester 
• 138479-11-5 diethyl 1-p-chlorophenyl-1-hydroxy-2-nitroethylphosphonate 
• 16656-47-6 diethyl [N-(hydroxy)imino](p-chlorophenyl)methylphosphonate 
• 27594-52-1 diethyl (p-chlorophenyl)carbamothioylphosphonate 
• 2617-79-0 N-(4-chlorophenyl)formamide 
• 27594-54-3 diethyl p-chlorobenzoylphosphoramidate 
• 74-11-3 para-chlorobenzoic acid 
• 82228-64-6 [(4-Chloro-phenyl)-(phenyl-hydrazono)-methyl]-phosphonic acid diethyl ester 
• 28504-38-3 [1,2-Bis-(4-chloro-phenyl)-2-(diethoxy-phosphoryl)-1,2-dihydroxy-ethyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Preparation of α-ketophosphonates by oxidation of α-hydroxyphosphonates with Pyridinium Chlorochromate (PCC)

Various types of diethyl α-hydroxyphosphonates were converted efficiently to their corresponding diethyl α-ketophosphonates by pyridiinum chlorochromate (PCC) without cleavage of C(O) - P bond in the absence of solvent or in solution in high yields.

Preparation of α-ketophosphonates by oxidation of α-hydroxyphosphonates with neutral alumina supported potassium permanganate (NASPP) under solvent-free conditions and potassium permanganate in dry benzene

Various types of α-hydroxyphosphonates were converted to α-ketophosphonates in high yields by potassium permanganate in dry benzene or by neutral alumina supported potassium permanganate (NASPP) under solvent-free conditions.

Surface-mediated solid-phase reactions: The preparation of acyl phosphonates by oxidation of 1-hydroxyphosphonates on the solid surface

Alumina-supported CrO3, under solvent-free conditions, was found to be an efficient oxidizing reagent for the preparation of acyl phosphonates from 1-hydroxyphosphonates. This method is an easy, rapid, and high-yielding reaction for the prepara

A convenient and mild protocol for preparation of α – trimethylsilyloxyphosphonates using sulfamic acid and their oxidation to α – ketophosphonates in the presence of N-bromosuccinimide

A convenient and mild protocol was developed for the trimethylsilylation of α-hydroxyphosphonates using hexamethyldisilazane as the silylating agent in the presence of sulfamic acid (SA) as a heterogeneous solid acid catalyst in dichloromethane as the rea

Enantioselective vinylogous aldol reaction of acylphosphonates with 3-alkylidene oxindoles

A simple strategy for yielding chiral tertiary α-hydroxy phosphonates that integrates two highly biologically relevant scaffolds namely 3-alkylidene-2-oxindoles and phosphonates has been described. The hydrogen bonding ability of the bifunctional thiourea catalyst allows simultaneous dual activation of a vinylogous oxindole nucleophile and an acylphosphonate electrophile, affording hydroxyphosphonato-3-alkylidene-2-oxindoles as aldol adducts in high yields (up to 92%) with excellent stereocontrol (up to 99% ee).

Highly efficient and extremely simple protocol for the oxidation α-hydroxyphosphonates to α-ketophosphonates using Dess-Martin periodinane

Dess-Martin periodinane has been demonstrated for the first time to be an efficient reagent in metal - free oxidation of α-hydroxyphosphonates to α-ketophosphonates under ambient conditions. Acquiescent reaction conditions and a simple isolation procedure

Visible photocatalysis of novel oxime phosphonates: Synthesis of β-aminophosphonates

A novel type of oxime phosphonate was synthesized and used in the intermolecular cascade radical addition reaction of alkenes to access β-aminophosphonates via visible-light-driven N-centered iminyl radical-mediated and redox-neutral selective C-P single-bond cleavage in an active phosphorus radical route. The procedure is characterized by its ability to achieve the construction of Csp3-P and Csp3-N bonds without the requirement for oxidants and bases.

Pd-catalyzed carbonylative access to aroyl phosphonates from (hetero)aryl bromides

The first transition-metal catalysed carbonylation with a phosphorus nucleophile is presented. This transformation provides efficient and mild access to aroylphosphonates under mild conditions, thus ensuring a broad substrate scope. The utility of aroylph

Asymmetric homoenolate additions to acyl phosphonates through rational design of a tailored N-heterocyclic carbene catalyst

A highly selective NHC-catalyzed synthesis of γ-butyrolactones from the fusion of enals and α-ketophosphonates has been developed. Computational modeling of competing transition states guided a rational design strategy to achieve enhanced levels of enanti

Nicotinium dichromate (= 3-carboxypyridinium dichromate; NDC) as an efficient reagent for the oxidative deamination of amines and aminophosphonates

A new method for the efficient synthesis of aldehydes, ketones, and oxophosphonates from various types of amines (primary and secondary) and aminophosphonates via oxidative deamination by nicotinium dichromate (= 3-carboxypyridinium dichromate; NDC) is described.