10583-67-2Relevant academic research and scientific papers
IN VIVO ASSEMBLY OF ASGPR BINDING THERAPEUTICS
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, (2022/02/28)
Compounds are provided that assemble together in vivo to form an ASGPR-binding compound that has an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein.
ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS
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, (2021/08/06)
Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.
Synthesis and evaluation of inhibitors of E. coli PgaB, a polysaccharide de-N-acetylase involved in biofilm formation
Chibba, Anthony,Poloczek, Joanna,Little, Dustin J.,Howell, P. Lynne,Nitz, Mark
, p. 7103 - 7107 (2012/10/08)
Many medically important biofilm forming bacteria produce similar polysaccharide intercellular adhesins (PIA) consisting of partially de-N-acetylated β-(1 → 6)-N-acetylglucosamine polymers (dPNAG). In Escherichia coli, de-N-acetylation of the β-(1 → 6)-N-
Synthesis and characterization of monosaccharide derivatives and application of sugar-based prolinamides in asymmetric synthesis
Agarwal, Jyoti,Peddinti, Rama Krishna
, p. 6390 - 6406,17 (2020/09/16)
For the first time, the β-anomer of N-acetylglucosamine derivative methyl 2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside (9b) was synthesized, isolated, and used in the synthesis of sugar-based primary amine 4b. Sugar-based primary amine 5a, a
Use of N,O-dimethylhydroxylamine as an anomeric protecting group in carbohydrate synthesis
Dasgupta, Somnath,Nitz, Mark
supporting information; experimental part, p. 1918 - 1921 (2011/06/24)
The N,O-dimethyloxyamine-N-glycosides are introducedas anomerically protected building blocks for carbohydrate synthesis. These N-glycosides are stable to a variety of protecting group manipulations including acylation, alkylation, silylation, and acetal formation. The alkoxyamine-N-glycosides can be cleaved selectively with N-chlorosuccinimide to give the desired hemiacetals in excellent yield. Furthermore, these Nglycosides are stable to the activation conditions required for glycosylation using thioglycoside and trichloroacetimidate glycosyl donors suggesting N,O-dialkoxyamine-N-glycosides will be useful for complex oligosaccharide synthesis.
Glucosamine-based primary amines as organocatalysts for the asymmetric aldol reaction
Agarwal, Jyoti,Peddinti, Rama Krishna
, p. 3502 - 3505 (2011/06/21)
Glucosamine derivatives have been synthesized starting from commercially available N-acetyl-D-glucosamine/glucosamine hydrochloride and have been employed successfully as efficient organocatalysts for the direct asymmetric aldol reaction between cyclohexa
26. A 1H-NMR spectroscopic investigation of the conformation of the acetamido group in some derivatives of N-acetyl-D-allosamine and -D-glucosamine
Fowler, Paul,Bernet, Bruno,Vasella, Andrea
, p. 269 - 287 (2007/10/03)
The population of the conformations obtained by rotation around the C(2)-N and the N-C(O) bonds of AllNAc, GlcNAc, and GlcNMeAc derivatives was investigated by 1H-NMR spectroscopy. The AllNAc-derived α -D- and β -D-pyranosides 4-7, the AllNAc d
NOUVELLE VOIE D'ACCES AUX 1,2-trans-2-AMINO-2-DESOXY-GLYCOPYRANOSIDES PAR L'INTERMEDIAIRE DES PHOSPHORAMIDATES DE 1,2-trans-2-DESOXY-2-IODOGLYCOPYRANOSYLES
Lafont, Dominique,Descotes, Gerard
, p. 35 - 48 (2007/10/02)
1,2-trans-2-Deoxy-2-iodoglycopyranosyl phosphoramidates (prepared from the corresponding glycals by addition of iodoazide, followed by Staudinger reaction with a phosphite) led by treatment with an alcohol in the presence of a base to the corresponding 1,2-trans-2-deoxy-2-phosphoramidoglycopyranosides, after inversion of configuration at C-1 and C-2.The reaction proceeded by an aziridine intermediate, which was opened by the alcohol present in the medium.Use of simple alcohols yielded alkyl glycosides having β-D-gluco, β-D-xylo, α-D-manno, and α-D-lyxo configurations, respectively, starting from α-D-manno, α-D-lyxo, β-D-gluco-, and β-D-xylo phosphoramidates, with excellent yields.The same reaction with an alcohol derived from galactopyranose led to the expected disaccharide with a low yield.
