106634-67-7

Basic information

• Product Name: Ethanone, 1-(2-amino-4,5-dimethylphenyl)- (9CI)
• Synonyms: Ethanone, 1-(2-amino-4,5-dimethylphenyl)- (9CI)
• CAS NO: 106634-67-7
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.21632
• Product Categories: ACETYLGROUP
• Mol File: 106634-67-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(2-amino-4,5-dimethylphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-amino-4,5-dimethylphenyl)- (9CI)(106634-67-7)
• EPA Substance Registry System: Ethanone, 1-(2-amino-4,5-dimethylphenyl)- (9CI)(106634-67-7)

Safety Data

• Hazardous Substances Data: 106634-67-7(Hazardous Substances Data)

Upstream product

• 15089-82-4 1-(4,5-dimethyl-2-nitrophenyl)ethanone 
• 2198-54-1 N-(3,4-dimethylphenyl)acetamide 
• 75-36-5 acetyl chloride 
• 15089-79-9 N-(2-acetyl-4,5-dimethylphenyl)acetamide 
• 50334-96-8 N-(3,4-dimethylphenyl)-3-oxobutanamide 
• 3637-01-2 3,4-dimethylacetophenone 
• 95-47-6 o-xylene 
• 95-64-7 4-amino-o-xylene 
• 75-05-8 acetonitrile 

Downstream Products

• 937817-37-3 2-[2-(2-acetyl-4,5-dimethylphenylamino)acetylamino]benzoic acid methyl ester 
• 15089-82-4 1-(4,5-dimethyl-2-nitrophenyl)ethanone 

Relevant articles and documents

X-ray Structures of 1-Ethynyl-2-Nitrobenzene and 1-Ethynyl-4,5-Dimethyl-2-Nitrobenzene: Correlation to the Enhanced Rate of Hydration and Investigation of the C–H···O Alkyne-Nitro Hydrogen Bonding

The single crystal X-ray structures of 2-nitrophenylacetylene, 1, and 4,5-dimethyl-2-nitrophenylacetylene, 2, are presented. In both structures the nitro moiety is essentially coplanar with the benzene ring and interacts with the proximal alkyne which is slightly distorted. The crystal packing of both compounds is dominated by intramolecular alkyne-nitro C–H···O hydrogen bonds that are supplemented by weak arene C–H···O (nitro) hydrogen bonds. Compound 1 crystallizes in the monoclinic space group P21/c with a?=?3.7874(5), b?=?13.0673(16), c?=?13.98174(17) ?, β?=?90.587(2) and Z?=?4. The molecule is disordered over two sites with occupancy ratio of 88:12. Compound 2 crystallizes in the triclinic space group P-1 with a?=?7.6080(5), b?=?9.8811(6), c?=?12.8240(8) ?, α?=?108.1760(10), β?=?102.4170, γ?=?96.6480(10) and Z?=?4. The intermolecular interactions in both structures were dominated by alkyne-nitro and arene-nitro C–H···O hydrogen bonds. Graphical Abstract: The structures of 2-nitrophenylacetylene and 4,5-dimethyl-2-nitrophenylacetylene display a strong nitro-alkyne intramolecular O···C interaction resulting in distortion of the alkyne and terminal alkyne-nitro CH···O intermolecular interactions. [Figure not available: see fulltext.]

Preparation method of 6,7-dimethyl-4-hydroxyquinoline

The invention discloses a preparation method of 6,7-dimethyl-4-hydroxyquinoline. A target product is prepared by taking 1-(3,4-dimethyl phenyl)ethanone as a starting raw material through nitration, reduction and ring closing. The compound is an important

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase

A series of potent anthranilic acid-based inhibitors of the hepatitis C NS5B polymerase has been identified. The inhibitors bind to a site on NS5B between the thumb and palm regions adjacent to the active site as determined by X-ray crystallography of the enzyme-inhibitor complex. Guided by both molecular modeling and traditional SAR, the enzyme activity of the initial hit was improved by approximately 100-fold, yielding a series of potent and selective NS5B inhibitors with IC50 values as low as 10 nM. These compounds were also inhibitors of the HCV replicon in cultured HUH7 cells.