106854-74-4

Basic information

• Product Name: 1-Methoxy-2-(2,2,2-trifluoroethoxy)benzene
• Synonyms: 1-Methoxy-2-(2,2,2-trifluoroethoxy)benzene
• CAS NO: 106854-74-4
• Molecular Formula: C₉H₉F₃O₂
• Molecular Weight: 206.1617696
• EINECS: -0
• Mol File: 106854-74-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 188.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.210±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-Methoxy-2-(2,2,2-trifluoroethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methoxy-2-(2,2,2-trifluoroethoxy)benzene(106854-74-4)
• EPA Substance Registry System: 1-Methoxy-2-(2,2,2-trifluoroethoxy)benzene(106854-74-4)

Safety Data

• Hazardous Substances Data: 106854-74-4(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Sweet, fruity

Uses

Solvent in pesticide production, intermediate in pharmaceutical synthesis

Flammability

Flammable

Health hazards

Causes irritation to eyes, skin, and respiratory system

Handling and storage

Handle with care, store in a well-ventilated area away from heat sources and incompatible materials.

Upstream product

• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 90-05-1 2-methoxy-phenol 
• 75-89-8 2,2,2-trifluoroethanol 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 
• 529-28-2 4-iodoanisol 

Downstream Products

• 160970-54-7 silodosin 
• 885340-11-4 2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile 
• 885340-13-6 1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carbonitrile 
• 160969-02-8 2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanol 
• 1269801-74-2 2-[2-(2,2,2-trifluoroethoxy)phenoxy-ethyl]-[1,3]dioxalane 
• 1269801-73-1 [2-(2,2,2-trifluoroethoxy)phenoxy]acetaldehyde 
• 160969-03-9 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene 
• 160969-00-6 1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene 

Relevant articles and documents

Synthesis and pharmacological evaluation of novel silodosin-based arylsulfonamide derivatives as α1A/α1D-adrenergic receptor antagonist with potential uroselective profile

Benign prostatic hyperplasia (BPH) is the most common male clinical problem impacting the quality of life of older men. Clinical studies have indicated that the inhibition of α1A-/α1D adrenoceptors might offer effective therapy in lower urinary tract symptoms. Herein, a limited series of arylsulfonamide derivatives of (aryloxy)ethyl alicyclic amines was designed, synthesized, and biologically evaluated as potent α1-adrenoceptor antagonists with uroselective profile. Among them, compound 9 (3-chloro-2-fluoro-N-([1-(2-(2-(2,2,2-trifluoroethoxy)phenoxy]ethyl)piperidin-4-yl) methyl) benzenesulfonamide) behaved as an α1A-/α1D-adrenoceptor antagonist (Ki(α1) = 50 nM, EC50(α1A) = 0.8 nM, EC50(α1D) = 1.1 nM), displayed selectivity over α2-adrenoceptors (Ki(α2) = 858 nM), and a 5-fold functional preference over the α1B subtype. Compound 9 showed adequate metabolic stability in rat-liver microsome assay similar to the reference drug tamsulosin (Clint = 67 and 41 μL/min/mg, respectively). Compound 9 did not decrease systolic and diastolic blood pressure in normotensive anesthetized rats in the dose of 2 mg/kg, i.v. These data support development of uroselective agents in the group of arylsulfonamides of alicyclic amines with potential efficacy in the treatment of lower urinary tract symptoms associated to benign prostatic hyperplasia.

PROCESS FOR THE PREPARATION OF INDOLINE DERIVATIVES AND THEIR INTERMEDIATES THEREOF

Processes for the preparation of Silodosin and its intermediates comprising reductive amination of compound of Formula (VIII) with a compound of Formula (VII) or a compound of Formula (XV) in a suitable solvent using a reducing agent.

NOVEL PROCESS FOR THE SYNTHESIS OF PHENOXYETHYL DERIVATIVES

The present invention provides an improved process for the synthesis of 2-[2- (2,2,2-trifluoroethoxy)phenoxy]ethanol intermediate, its derivatives and/or its pharmaceutically acceptable salts, useful in the synthesis of α-1 adrenoceptor blockers such as silodosin.