107112-93-6Relevant articles and documents
Synthesis method of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride
-
, (2017/09/02)
The invention relates to a synthesis method of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride. The method comprises the following steps: synthesizing 2-(2-thienyl)ethyl p-toluenesulfonate from 2-thiopheneethanol and paratoluensulfonyl chloride, further reacting the 2-(2-thienyl)ethyl p-toluenesulfonate with formamide to synthesize N-2-thienylethylformamide, carrying out cyclization on the N-2-thienylethylformamide under the action of trifluoroacetic acid to produce 6,7-dihydrothieno[3,2-c]pyridine, reducing the 6,7-dihydrothieno[3,2-c]pyridine with sodium borohydride, and carrying out salification to obtain the 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride. The invention provides a novel method for synthesizing the 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride. The method has the characteristics of low cost, low toxicity and simple technique, and has industrialized application prospects.