1072106-67-2

Upstream product

• 1072106-54-7 2-phenylimidazo[1,2-a]pyridin-3-amine hydrochloride 
• 586-78-7 para-nitrophenyl bromide 
• 67292-98-2 3-nitro-2-phenylimidazo<1,2-a>pyridine 
• 67625-22-3 2-bromo-3-nitro-imidazo[1,2-a]pyridine 
• 98-80-6 phenylboronic acid 
• 112581-95-0 2-Bromoimidazo[1,2-a]pyridine 
• 504-29-0 2-aminopyridine 
• 3999-05-1 2-chloroimidazo[1,2-a]pyridine 
• 126202-06-0 2-(2-imino-1,2-dihydropyridin-1-yl)acetic acid 
• 4926-52-7 2-chloro-3-nitroimidazo[1,2-a]pyridine 
• 3999-29-9 2-phenylimidazo[1,2-a]pyridin-3-amine 

Relevant academic research and scientific papers

Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a] pyridine: Expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

Alternative strategies for functionalizing 2-chloro-3-nitroimidazo[1,2-a] pyridine have been developed. Suzuki-Miyaura cross-coupling reaction provided easily the corresponding 2-arylated compounds, and herefrom the nitro group was reduced into amine which afforded amides, anilines, and ureas in the 3-position. The amination of the key compound using a metal-catalyzed reaction was reported. This study highlighted the importance of the nitro group to facilitate the chlorine displacement. Other nucleophilic aromatic substitutions open a route to various products derived from imidazo[1,2-a]pyridine.

Greater variety in Groebke-Blackburn type 3-arylaminoimidazo[1,2-a]azines accessed via Pd-catalyzed arylation of a primary amine precursor

The scope of the Groebke-Blackburn reaction of 2-aminoazines is limited by the availability of isocyanides. To prepare the Groebke-Blackburn type 2-phenyl-3-(hetero)arylaminoimidazo[1,2-a]azines, for which the respective (hetero)arylisocyanides are scarce