107410-07-1

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxybiphenyl-3-carboxylic acid is used as a reagent for the preparation of polymyxin derivatives, which are potent antibacterial agents. These polymyxin derivatives exhibit broad-spectrum antimicrobial activity and are particularly effective against gram-negative bacteria, including antibiotic-resistant strains. The use of 4-Methoxybiphenyl-3-carboxylic acid in the synthesis of these derivatives contributes to the development of new and more effective treatments for bacterial infections.

Upstream product

• 63471-87-4 4-(4-methoxy-biphenyl-3-yl)-4-oxo-butyric acid 
• 108593-48-2 4-methoxy-3-methyl-1,1'-biphenyl 
• 143-66-8 sodium tetraphenyl borate 
• 2476-35-9 5-bromo-2-methoxybenzoic acid 
• 412027-31-7 2-methoxy-5-phenylacetophenone 
• 100-34-5 benzene diazonium chloride 
• 98-80-6 phenylboronic acid 
• 89-55-4 5-bromosalicyclic acid 
• 7120-41-4 methyl 5-bromo-2-methoxybenzoate 
• 17504-10-8 methyl 4-methoxy-[1,1'-biphenyl]-3-carboxylate 
• 95-48-7 ortho-cresol 
• 6415-38-9 benzenediazonium sulphate 
• 30451-49-1 3-methyl-[1,1'-biphenyl]-4-ol 

Downstream Products

• 613-37-6 4-methoxylbiphenyl 
• 323-87-5 4-hydroxybiphenyl-3-carboxylic acid 

Relevant academic research and scientific papers

Palladium charcoal-catalyzed, ligandless Suzuki reaction by using tetraarylborates in water

In water and without using any ligand, palladium charcoal-catalyzed Suzuki coupling reaction of tetraarylborates with aryl bromides could be achieved in excellent yield. A concise mechanism consisting of four catalytic cycles is depicted in this paper.

Sulfonamide compound and medical applications thereof

The invention discloses a compound containing a sulfonamide structure, a preparation method thereof, and medical applications of the compound, and more specifically discloses the compound with a structure represented by formula I, and a pharmaceutically acceptable salt or a prodrug or a solvate thereof. The compound is used for tumor treatment through inhibiting ATP-citrate lyase.

Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs

A series of compounds containing one or two salicylic acid moieties were synthesized, and their efficacy to inhibit the phosphohydrolase activity of PTP1B examined. Some of the methylenedisalicylic acid derivatives were potent inhibitors of PTP1B. Of those derivatives, 3c exhibited about a 14-fold selectivity against TC-PTP, and this compound was tested in a mouse model for its efficacy to prevent diet-induced obesity. It effectively suppressed the increases in body weight and adipose mass, without any noticeable toxic effect. The compound also prevented increases in the plasma triglyceride, cholesterol, and nonesterified fatty acid concentrations; thus, expanding its therapeutic potential to other related metabolic diseases, such as hyperlipidemia and hypercholesterolemia.

AMIDINOPHENYLPYRUVIC ACID DERIVATIVES

An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood coagulation factor VII.