107487-79-6

Upstream product

• 110029-70-4 (4-chloro-phenacyl)-dimethyl-phenacyl-ammonium; bromide 
• 1074-12-0 phenylglyoxal hydrate 
• 99-91-2 para-chloroacetophenone 
• 6048-29-9 triphenylphenacylphosphonium bromide 
• 4998-15-6 4-chlorophenylglyoxal 
• 126314-18-9 4-phenyl-1-(p-chlorophenyl)-1-butanone 
• 70-11-1 α-bromoacetophenone 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 888474-32-6 cis-1-(4-Chlorophenyl)-4-phenylbut-2-ene-1,4-dione 
• 107487-68-3 1-(4-Chloro-phenyl)-2-(3-phenyl-1,2-dihydro-quinoxalin-2-yl)-ethanone 
• 1050338-12-9 C₂₁H₁₉ClO₆ 
• 1206778-55-3 C₂₁H₁₈ClNO₄ 
• 60721-33-7 1-(4-chlorophenyl)-4-phenylbutane-1,4-dione 

Relevant academic research and scientific papers

Proton-Coupled Electron Transfer: Transition-Metal-Free Selective Reduction of Chalcones and Alkynes Using Xanthate/Formic Acid

Highly chemoselective reduction of α,β-unsaturated ketones to saturated ketones and stereoselective reduction of alkynes to (E)-alkenes has been developed under a transition-metal-free condition using a xanthate/formic acid mixture through proton-coupled electron transfer (PCET). Mechanistic experiments and DFT calculations support the possibility of a concerted proton electron-transfer (CPET) pathway. This Birch-type reduction demonstrates that a small nucleophilic organic molecule can be used as a single electron-transfer (SET) reducing agent with a proper proton source.

Aerobic Oxidative Dehydrogenation of Ketones to 1,4-Enediones

An efficient and unprecedented strategy for the synthesis of 1,4-enediones from saturated ketones has been developed via palladium-catalyzed oxidative dehydrogenation. The protocol employs molecular oxygen as the sole oxidant and represents an atom- and step-economic process. The approach showed broad substrate scope, good functional group tolerance, and complete E-stereoselectivity. The reaction mechanism has been investigated through deuterium-labeling experiments and intermediate experiments.

Synthesis of (E)-1,4-enediones from α-halo ketones through a sodium sulfinate mediated reaction

We developed a mild and practical protocol for the synthesis of 1,4-enedione from α-halo ketones through a sodium sulfinate mediated reaction. This reaction enables the construction of symmetric and unsymmetric 1,4-enedione with complete E selectivity. Sodium 4-toluenesulfinate plays an important role in this reaction.

Development of the Julia asymmetric epoxidation reaction. Part 2. Application of the oxidation to alkyl enones, enediones and unsaturated keto esters

Polyleucine-based systems have been used to catalyse the asymmetric oxidation of a variety of alkyl enones 1-4, 9-14, an enynone 16 and a dienone 17 to afford the corresponding epoxides 5-8, 18-26 in good to excellent yield and optical purity. A range of enediones 30-32, 34 and one unsaturated keto ester 33 have also been epoxidised stereoselectively to afford optically active epoxides 35-39. The epoxidations were carried out with basic peroxide as the oxidant; the polyleucine catalyst was prepared from leucine N-carboxyanhydride using 1,3-diaminopropane, water (employing a humidity cabinet) or a polystyrene immobilised amine as the initiator. Preliminary mass spectral data on material derived from L-leucine and 1,3-diaminopropane (DAP-PLL) suggest that the catalyst consists of material that contains 22 ± 10 leucine residues.