1566616-95-2

Upstream product

• 2918-91-4 N,N-diphenyl methacrylamide 
• 66003-76-7 Diphenyliodonium triflate 
• 71-43-2 benzene 
• 100-63-0 phenylhydrazine 
• 74-88-4 methyl iodide 
• 3335-98-6 1-phenyl-1,3-dihydro-indol-2-one 
• 100-52-7 benzaldehyde 
• 1075174-08-1 (E)-3-benzylidene-1-phenylindolin-2-one 

Relevant academic research and scientific papers

Copper-catalyzed oxidative electrophilic carbofunctionalization of acrylamides for the synthesis of oxindoles

A novel and efficient copper-catalyzed tandem oxidative cyclization of arylacrylamides with diaryliodonium salts is reported. This reaction provides a novel approach for the synthesis of oxindoles and various functional groups were well tolerated.

The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl Compounds

Sodium hydride was employed as a Michael donor under the catalysis of PdCl2 for 1,4-conjugate reductions of α, β-unsaturated carbonyl compounds, which features operational simplicity, mild conditions and high atom-economy. The merits of NaH as a reductant were demonstrated by the one-pot or cascade reactions for the syntheses of complex molecules. (Figure presented.).

3,3-disubstituted oxoindole and preparation method thereof

The invention discloses 3,3-disubstituted oxoindole and a preparation method thereof. Reaction comprises the following steps that an alkenyl active methylene compound is used as a substrate, a metal hydride is used as a reducing agent, a palladium compoun

Electrochemical cobalt-catalyzed C-H or N-H oxidation: A facile route to synthesis of substituted oxindoles

Two comparable protocols for the electrochemical cobalt-catalyzed C-H/N-H oxidation have been exploited for the synthesis of substituted oxindoles via radical pathways. The electrochemical cobalt-catalyzed system was demonstrated to be efficient and eco-friendly and avoided the use of stoichiometric oxidants to afford the arylation or alkylation products in good yields at room temperature.

Copper(I)-catalyzed aryl or vinyl addition to electron-deficient alkenes cascaded by cationic cyclization

An exoselective copper-catalyzed arylation- and vinylation-carbocyclization of electron-deficient alkenes was developed to provide rapid and efficient access to a variety of functionalized 3,3-disubstituted oxindoles. With this method, a highly efficient and concise formal synthesis of (±)- physostigmine and (±)-physovenine has been completed.

Copper-catalyzed bis-arylations of alkenes leading to oxindole derivatives

A simple and practical copper-catalyzed approach to oxindole derivatives by copper-catalyzed bis-arylation of N-alkyl-N-phenylacrylamides with diaryliodonium triflates has been developed under mild conditions, and the method is of tolerance towards some functional groups in the substrates. This journal is the Partner Organisations 2014.