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Relevant academic research and scientific papers

Synthesis and application of axially chiral biscarbolines with functional N-O and sulfone for 1,2-transfer hydrogenations of ketimines

A series of axially chiral biscarboline-based sulfones were synthesized from L-tryptophane and applied for enantioselective 1,2-transfer hydrogenations of ketimines using trichlorosilane. The catalyst 4e, which had a tertiary butyl group, exhibited a good conversion and high enantioselectivities up to 96%ee in the series of reactions.

An efficient proline-based homogeneous organocatalyst with recyclability

In this work, a homogeneous organocatalyst was developed for the asymmetric reduction of imines. This catalyst could be separated by cyclodextrin-modified Fe3O4@SiO2 magnetic nanoparticles and then released back into a fre

Chiral cyclometalated iridium complexes for asymmetric reduction reactions

A series of chiral cyclometalated iridium complexes have been synthesised by cyclometalating chiral 2-aryl-oxazoline and imidazoline ligands with [Cp?IrCl2]2. These iridacycles were studied for asymmetric transfer hydrogenation reactions with formic acid as the hydrogen source and were found to display various activities and enantioselectivities, with the most effective ones affording up to 63% ee in the asymmetric reductive amination of ketones and 77% ee in the reduction of pyridinium ions. This journal is

New chiral biscarboline N,N′-dioxide derivatives as catalyst in enantioselective reduction of ketoimines with trichlorosilane

New axial N,N′-dioxide secondary amide derived from l-tryptophan was synthesized and firstly employed in catalytic enantioselective reduction of ketoimines with trichlorosilane. It was found that 4f was an effective catalyst with excellent reactivity and

Highly efficient asymmetric-axle-supported N-O amides in enantioselective hydrosilylation of ketimines with trichlorosilane

A novel asymmetric-axle-supported chiral N-O amide was synthesized and used in catalytic enantioselective hydrosilylation of N-aryl ketimines with HSiCl3 at room temperature instead of the typical -20°C. High conversion yield and high enantiose

Cooperative catalysis: Combining an achiral metal catalyst with a chiral Br?nsted acid enables highly enantioselective hydrogenation of imines

Asymmetric hydrogenation of imines leads directly to chiral amines, one of the most important structural units in chemical products, from pharmaceuticals to materials. However, highly effective catalysts are rare. This article reveals that combining an ac

Highly enantioselective synthesis of chiral secondary amines by gold(I)/ chiral bronsted acid catalyzed tandem intermodular hydroamination and transfer hydrogenation reactions

A method for the synthesis of enantiomerically enriched secondary amines with excellent ee values through the tandem intermolecular hydroamination/ transfer hydrogenation of alkynes using a "gold(I) complex-chiral Bronsted acid" protocol is developed. The

Chiral counteranion-aided asymmetric hydrogenation of acyclic imines

When combined with a chiral phosphate counteranion, a chiral diamine-ligated Ir(III) catalyst displayed excellent enantioselectivities in the asymmetric hydrogenation of a wide range of acyclic imines, affording chiral amines in up to 99% ee. Copyright