108446-77-1

Usage

Uses

Used in Pharmaceutical Industry:
1,3-DIPHENYLPYRAZOLE-4-PROPIONIC ACID is used as a pharmaceutical intermediate for the synthesis of various drugs, particularly in the development of anti-inflammatory and analgesic medications. Its unique structure and properties make it a valuable building block in the design and synthesis of novel therapeutic agents.
1,3-DIPHENYLPYRAZOLE-4-PROPIONIC ACID is also used as a key component in the development of anti-cancer drugs. Its potential anti-cancer properties have been studied, and it has shown promise in targeting various types of cancer cells. 1,3-DIPHENYLPYRAZOLE-4-PROPIONIC ACID's ability to modulate signaling pathways and inhibit tumor growth makes it a promising candidate for further research and development in oncology.
Used in Organic Synthesis:
1,3-DIPHENYLPYRAZOLE-4-PROPIONIC ACID serves as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical compounds with diverse applications. Its unique structure allows for various chemical reactions and modifications, making it an essential component in the synthesis of complex organic molecules.

InChI:InChI=1/C18H16N2O2/c21-17(22)12-11-15-13-20(16-9-5-2-6-10-16)19-18(15)14-7-3-1-4-8-14/h1-10,13H,11-12H2,(H,21,22)

Upstream product

• 73221-47-3 (E)-3-(1,3-Diphenyl-1H-pyrazol-4-yl)-acrylic acid 
• 100-63-0 phenylhydrazine 
• 98-86-2 acetophenone 
• 108446-83-9 2-(1,3-Diphenyl-1H-pyrazol-4-ylmethylene)-malonic acid diethyl ester 
• 108446-65-7 2-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)malonic acid 
• 583-11-9 N-(1-phenylethylidene)phenylhydrazine 
• 21487-45-6 1,3-diphenyl-4-formylpyrazole 
• 2033-24-1 cycl-isopropylidene malonate 

Downstream Products

• 680190-67-4 1,3-diphenyl-4-chloro-1H-thieno[2,3-c]pyrazole-5-carbonyl chloride 
• 519137-53-2 3-(1,3-diphenyl-1H-pyrazol-4-yl)-propionyl chloride 

Relevant academic research and scientific papers

Synthesis of 3-(1, 3-diphenyl-1H-pyrazol-4-yl) propanoic acids using diimide reduction

Pyrazole-1H-4-yl-acrylic acids (3a-j) were prepared from pyrazole-1H-4-carbaldehydes which in turn were prepared by the Vilsmeier-Haack reaction of phenyl hydrazone derivatives (1a-j). The reaction of pyrazole-1H- 4-yl-acrylic acids to 3-(1, 3-diphenyl-1H

Synthesis and biological evaluation of some novel 3-(1,3-diphenyl-1H- pyrazol-4-yl) propanoic acids

Vilsmeier-Haack reaction of phenyl hydrazone derivatives (1a-j) afforded 1,3-diphenyl-1 W-pyrazole-4-carbaldehydes (2a-j). Condensation of (2a-j) with malonic acid gave 3-(1,3-diphenyl-1/-/-pyrazol-4-yl) acrylic acids (3a-j. Reduction of (3a-j) gave 3-(1,

A simple and rapid synthesis of 4H-4-oxo-1-benzopyran-3-yl and 1,3-diarylpyrazol-4-yl propanoic acids

A simple and rapid synthesis of 4H-4-oxo-1-benzopyran-3-yl (4a-h) and 1,3-diarylpyrazol-4-yl propanoic acids (5a-h) using Meldrum's acid (1) from the corresponding carboxaldehydes (2 & 3) is reported herein.

Functionally substituted 3-heterylpyrazoles: XI. 3-[3-Aryl(heteryl)pyrazol-4-yl]propenoic and propanoic acids

3-Aryl(heteryl)-4-formylpyrazoles by condensation with malonic acid furnish 3-[3-aryl(heteryl)-pyrazol-4-yl]propenoic acids that in the presence of Raney nickel are reduced by hydrazine hydrate to 3-[3-aryl(heteryl)pyrazol-4-yl]propanoic acids. The succes

A PERICYCLIC CASCADE IN THE ADDITION OF DIPHENYL NITRILE IMINE TO PYRIDINE

On refluxing in benzene in the presence of excess pyridine the monocycloadduct of diphenyl nitrile imine to pyridine smoothly undergoes a sigmatropic shift and a subsequent electrocyclic opening to afford 1,2,4-triazole derivatives.

Azoles. 17. Beta-(4-pyrazol)acrylic and propionic acids and their anti-inflammatory activity

beta-(4-Pyrazole)acrylic acids 22-28 were prepared by the Knoevenagel reaction of malonic acid and 4-formylpyrazoles 8-14. 4-Pyrazolemethylenemalonic acids 15-21 were isolated as intermediates. The latter compounds were also synthesized by treating the 4-formylpyrazoles 8-14 with diethyl malonate followed by hydrolysis of the obtained diethyl esters 15a-21a. The effect of piperidine and pyridine on the Knoevenagel condensation was investigated. The beta-(4-pyrazole)acrylic acids 22-27, on catalytic reduction, gave the corresponding beta-(4-pyrazole)propionic acids 29-34. Compounds 23, 24, 27, 29-31 and 34 appeared to be less active than phenylbutazone in carrageenin-induced oedema test, but they were less toxic than the reference drug.