1086400-66-9

Basic information

• Product Name: (Z)-2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoic acid ethyl ester
• Synonyms: (Z)-2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoic acid ethyl ester
• CAS NO: 1086400-66-9
• Molecular Weight: 222.189
• Mol File: 1086400-66-9.mol

Chemical Properties

• CAS DataBase Reference: (Z)-2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoic acid ethyl ester(1086400-66-9)
• EPA Substance Registry System: (Z)-2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoic acid ethyl ester(1086400-66-9)

Safety Data

• Hazardous Substances Data: 1086400-66-9(Hazardous Substances Data)

Upstream product

• 454-31-9 ethyl difluoroacetate 
• 141-78-6 ethyl acetate 
• 122-51-0 orthoformic acid triethyl ester 
• 352-24-9 ethyl 4,4-difluoro-3-oxobutyrate 

Downstream Products

• 141573-96-8 3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride 
• 176969-34-9 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 
• 1415089-24-5 2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide 
• 1415089-57-4 2-(difluoromethyl)-5-(isobutyramidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide phosphoric acid 
• 1226886-76-5 N-[4-chloro-3-(cyclopropylcarbamoyl)phenyl]-4-(difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxamide 
• 141573-95-7 ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate 
• 151733-96-9 ethyl 3-(difluoromethyl)-1H-pyrazole-4-carboxylate 
• 1204298-65-6 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

ASK1 INHIBITING AGENTS

Provided are compounds of Formula (I): Formula (I), including compounds of Formulas (II), (III), (IV), (V) and (VI), wherein X, R1, R2, R3, R4 and n are as defined herein,and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).

Heterocycle-containing two fragrant amines pyrazoles carboxamides and preparation method and application thereof (by machine translation)

The present invention provides a kind of formula (I) indicated by the heterocycle-containing two fragrant amines pyrazoles carboxamides and its preparation method and application, this compound to the agricultural, civil and animal in the technical field of the imago harmful mite and insects, nit and egg demonstrate high insecticidal activity, while at the same time the compound exhibits a good bactericidal activity; (by machine translation)

SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

Novel Imidazole Derivatives Useful for the Treatment of Arthritis

The present invention provides compounds of the formula below: where A, X and R1-R6 are as described herein, a pharmaceutical salt thereof, and a pharmaceutical composition containing this compound; methods of treating pain associated with osteoarthritis using one of the compounds or a pharmaceutically acceptable salt thereof, and processes for preparing the compounds.

PROCESS FOR PREPARING ALKYL 2-ALKOXYMETHYLENE-4,4-DIFLUORO-3-OXOBUTYRATES

The present invention relates to a process for preparing a compound of formula (Il) wherein R1 is CF3, CF2H or CFH2, and R2 and R3 are both independently C1-C6 alkyl, comprising a) reacting compounds of formula (IV), (V) and (Vl) wherein R3 is as defined for the compound of formula (II), R4OM (V) wherein M is a lithium, sodium or potassium ion and R 4 is C1-C6 alkyl, and (Vl) wherein R1 is as defined for the compound of formula (Il) and R5 is CrC6 alkyl, to form an enolate of formula (VII) wherein M is as defined for the compound of formula V and R1 and R3 are defined for the compound of formula (II), b) releasing the compound of formula (VIII) wherein R1 and R3 are as defined for the compound of formula (II), from the enolate of formula (VII) by means of an acid, and c) converting the compound of formula (VIII), in the presence of the salt formed from cation M and the anion of the acid in step b), to a compound of formula (II).

5-MEMBERED HETEROCYCLIC AMIDES AND RELATED COMPOUNDS

5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly usef

1-METHYL-3-DIFLUOROMETHYL-PYRAZOL-4-CARBONIC ACID-(ORTHO-PHENYL)-ANILIDES, AND USE THEREOF AS A FUNGICIDE

The invention relates to 1-methyl-3-difluoromethyl-pyrazol-4-carbonic acid-(ortho-phenyl)-anilides of formula (I), wherein the substituents have the following meaning: R1 and R2 independently represent halogen, C1-C6 alkyl, C1-C6 alkyl halide, cyano, nitro, methoxy, trifluoromethoxy, or difluoromethoxy.