176969-34-9

Basic information

• Product Name: 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
• Synonyms: 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid;3-Difluoromethyl-1-methyl-1H-pyrazol-4-carboxylic acid;3-Difluoromethyl-1-methylpyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylicacid, 3-(difluoroMethyl)-1-Methyl-;3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxyl
• CAS NO: 176969-34-9
• Molecular Formula: C₆H₆F₂N₂O₂
• Molecular Weight: 176.121
• Product Categories: Building Blocks;Pyrazole
• Mol File: 176969-34-9.mol
• Article Data: 75

Chemical Properties

• Boiling Point: 315.9 °C at 760 mmHg
• Flash Point: 144.851 °C
• Appearance: /
• Density: 1.52
• Vapor Pressure: 0.000179mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Sparingly)
• PKA: 3.12±0.36(Predicted)
• CAS DataBase Reference: 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid(176969-34-9)
• EPA Substance Registry System: 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid(176969-34-9)

Safety Data

• Hazardous Substances Data: 176969-34-9(Hazardous Substances Data)

Usage

Chemical Properties

Light brown powder

Uses

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid can be used to prepare pesticides.

InChI:InChI=1/C6H6F2N2O2/c1-10-2-3(6(11)12)4(9-10)5(7)8/h2,5H,1H3,(H,11,12)

Synthetic route

1-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)ethan-1-one → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With manganese(II) acetate dihydrate; acetic acid at 100℃; for 18h; Reagent/catalyst;	100%
With sodium hypochlorite; sodium hydroxide In water at 70℃; for 2h; Temperature; Reagent/catalyst;	98%
With sodium hypochlorite In water at 0℃; for 0.166667h; Temperature; Time;	98%

ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate (141573-95-7) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With sodium hydroxide In toluene at 65℃; for 0.75h;	98%
With sodium hydroxide In ethanol; water at 50 - 80℃; for 3h;	95%
With water; sodium hydroxide	95%

hexylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With water; sodium hydroxide In methanol at 60℃; for 4h;	96.3%

3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride (141573-96-8) + C12H13Cl2NO (1263184-89-9) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) + benzovindiflupyr

Conditions	Yield
Stage #1: 3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride; C12H13Cl2NO With triethylamine In 1,4-dioxane at 25 - 82℃; for 3h; Stage #2: With sodium hydroxide In tert-butyl methyl ether; water for 0.5h; Stage #3: With hydrogenchloride In tert-butyl methyl ether; water	A 96% B 92%

3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonitrile (1049772-84-0) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With sodium hydroxide In water at 90 - 100℃;	95%
Stage #1: 3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonitrile With water; sodium hydroxide at 95℃; for 4h; Stage #2: With hydrogenchloride; water at 20℃; Cooling with ice;	92%
With water; sodium hydroxide In methanol for 2h; Solvent; Reflux; Further stages;	92.1%
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In water; toluene at 70℃; for 8h;

hexyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With water; sodium hydroxide at 60℃; for 2h;	95%

methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With manganese(II) nitrate; oxygen; acetic acid; ferric nitrate at 80℃; for 20h;	95%

3-(difluoromethyl)-1-methyl-4-(1,3-dioxolan-2-yl)-1H-pyrazole → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(1,3-dioxolan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h; Reagent/catalyst;	93.2%

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxan-2-yl)-1H-pyrazole → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h;	92.3%

ethylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With water; sodium hydroxide In methanol at 60℃; for 4h; Reagent/catalyst;	92%

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxepan-2-yl)-1H-pyrazole → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxepan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h;	92%

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-1H-pyrazole → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With sodium hypochlorite In water at 10 - 100℃; for 5h;	91.8%

3-(difluoromethyl)-4-(1,3-dioxan-2-yl)-1-methyl-1H-pyrazole → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: 3-(difluoromethyl)-4-(1,3-dioxan-2-yl)-1-methyl-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h; Reagent/catalyst;	91.6%

3-(difluoromethyl)-1-methyl-4-(1,3-dioxepan-2-yl)-1H-pyrazole → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(1,3-dioxepan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h; Reagent/catalyst;	91.5%

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde (1094484-55-5) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With sodium hypochlorite at 10 - 100℃; for 5h;	91.3%
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde With sodium hydroxide; dihydrogen peroxide In water at 40 - 45℃; for 1.5h; Stage #2: With hydrogenchloride In water pH=2.5; Product distribution / selectivity;	69 %Chromat.
With copper(II) oxide; sodium hydroxide In water at 25 - 30℃; for 24h;	32 g

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxetan-2-yl)-1H-pyrazole → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxetan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With sodium hypochlorite In water at 10 - 100℃; for 5h; Reagent/catalyst;	91.3%

2,2-dichloro-1-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)ethanone → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With sodium hypochlorite; water In chloroform at 24℃; for 4h; Reagent/catalyst; Inert atmosphere;	91%
With sodium hypochlorite; sodium hydroxide In water at 22 - 70℃; for 2h;

3-(difluoromethyl)-4-(1,3-dioxetan-2-yl)-1-methyl-1H-pyrazole → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: 3-(difluoromethyl)-4-(1,3-dioxetan-2-yl)-1-methyl-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With sodium hypochlorite In water at 10 - 100℃; for 5h; Reagent/catalyst;	91%

methyl-3-(dichloromethyl)-1-methyl-1H-pyrazole-4-carboxylate → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) + 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (1204298-65-6)

Conditions	Yield
With 1,3-dimethyl-2-imidazolidinone; hydrogen fluoride; triethylamine at 125 - 155℃; Reagent/catalyst; Temperature; Concentration; Autoclave;	A 90.1% B n/a

3-(difluoromethyl)-4-(furan-2-yl)-1-methyl-1H-pyrazole → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With sodium periodate; rhodium(III) chloride hydrate In tetrachloromethane; water; acetonitrile at 20℃; for 0.75h;	90%

3-bromo-1-methyl-1H-pyrazole-4-carboxylic acid + difluoromethylboronic acid → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 65 - 75℃; for 1.5h; Solvent; Reagent/catalyst; Inert atmosphere;	89.2%

(E/Z)-ethyl 2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoate + methylhydrazine (60-34-4) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: methylhydrazine With benzaldehyde In water; toluene at 25 - 60℃; for 6.16667h; Inert atmosphere; Stage #2: (E/Z)-ethyl 2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoate In water; toluene at 20 - 30℃; for 19h; Product distribution / selectivity;	86.1%

4-bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole (1089212-38-3) + carbon dioxide (124-38-9) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: 4-bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole With TurboGrignard In 2-methyltetrahydrofuran at -5℃; for 2h; Inert atmosphere; Heating; Stage #2: carbon dioxide In 2-methyltetrahydrofuran at -25 - 0℃; for 5h; Reagent/catalyst; Solvent; Inert atmosphere;	84.6%

ethyl 4,4-difluoro-3-oxobutyrate (352-24-9) + methylhydrazine (60-34-4) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: ethyl 4,4-difluoro-3-oxobutyrate With calcium acetate; orthoformic acid triethyl ester at 100 - 110℃; for 2h; Stage #2: methylhydrazine With sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene; water at 10 - 20℃; for 0.5h;	83.3%

carbon dioxide (124-38-9) + 3-(difluoromethyl)-4-iodo-1-methyl-1H-pyrazole → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
Stage #1: 3-(difluoromethyl)-4-iodo-1-methyl-1H-pyrazole With isopropylmagnesium chloride In tetrahydrofuran at -5℃; for 2h; Inert atmosphere; Heating; Stage #2: carbon dioxide With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at -25 - 0℃; for 5h; Inert atmosphere;	83.2%

potassium 2-difluoroacetyl-3-(diethylamino)acrylate + methylhydrazine (60-34-4) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With potassium iodide In water at -30 - -20℃; for 2h; Inert atmosphere;	79.6%

sodium 2-difluoroacetyl-3-(dimethylamino)acrylate + methylhydrazine (60-34-4) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With sodium iodide In water at -30 - 20℃; for 2h; Inert atmosphere;	78.3%

sodium 2-difluoroacetyl-3-(diethylamino)acrylate + methylhydrazine (60-34-4) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With sodium iodide at -30 - -25℃; for 2h; Inert atmosphere;	77.1%

potassium 2-difluoroacetyl-3-(dimethylamino)acrylate → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With methylhydrazine; potassium iodide In water at -30 - -20℃; for 2h; Inert atmosphere;	75.9%

sodium 2-difluoroacetyl-3-(2,2,6,6-tetramethylpiperidin-1yl)acrylate + methylhydrazine (60-34-4) → 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9)

Conditions	Yield
With sodium iodide at -30 - -20℃; for 2h; Inert atmosphere;	75.8%

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) → 3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride (141573-96-8)

Conditions	Yield
With thionyl chloride In chlorobenzene at 110℃; for 3h;	98%
With thionyl chloride In toluene at 90℃;	92.1%
With thionyl chloride; N,N-dimethyl-formamide In 1,2-dichloro-ethane for 5h; Reflux;	90%

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) → 1-methyl-3-(difluoromethyl)-1H-pyrazole-4-amide (925689-10-7)

Conditions	Yield
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 0.5h; Stage #2: With ammonium hydroxide In dichloromethane Cooling with ice;	98%
Multi-step reaction with 2 steps 1: thionyl chloride / 4 h / Reflux 2: ammonium hydroxide / dichloromethane / 4 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: thionyl chloride / 4 h / Reflux 2: ammonium hydroxide / tetrahydrofuran View Scheme
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C 2: ammonium hydroxide / dichloromethane / 0 °C View Scheme
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: With ammonium hydroxide at 0 - 20℃;

methanol (67-56-1) + 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) → methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

Conditions	Yield
With sulfuric acid at 75℃; for 8h;	97.2%

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) + tert-butyl alcohol (75-65-0) → tert-butyl (3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carbamate

Conditions	Yield
With diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine at 20 - 90℃; for 4.16667h; Inert atmosphere;	94%
With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine at 20 - 90℃; for 4.16667h; Curtius Rearrangement; Inert atmosphere;	94%
With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine at 20 - 90℃; for 4.5h; Inert atmosphere;	91%

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) + 5-amino-9-syn-isopropyl-benzonorbornene → C20H23F2N3O

Conditions	Yield
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In dichloromethane at 20℃; for 21h;	92.6%

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) + C14H19N → C20H23F2N3O

Conditions	Yield
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In dichloromethane at 20℃; for 3h;	91.7%

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) → tert-butyl (3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carbamate

Conditions	Yield
With diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine In tert-butyl alcohol at 20 - 90℃; for 4.5h; Inert atmosphere;	91%

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy,N-methyl-1-methyl-3-(difluoromethyl)-1H-pyrazole-4-carboxylic amide

Conditions	Yield
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 0.5h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃;	91%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;	91%

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) → 3-(difluoromethyl)-4-iodo-1-methyl-1H-pyrazole

Conditions	Yield
With potassium iodate; sulfuric acid; iodine; acetic acid In sulfolane at 45 - 60℃; for 1.33h;	90%
Multi-step reaction with 3 steps 1.1: diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine / 4.17 h / 20 - 90 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C 3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C 3.2: 0.5 h View Scheme
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / 4.17 h / 20 - 90 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C 3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C 3.2: 0.5 h / 20 °C View Scheme

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (176969-34-9) + C12H17BrN2O2S → N-(2-bromophenyl)-2-(1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylamino)-cyclohexylsulfonamide

Conditions	Yield
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 2h; Inert atmosphere; Stage #2: C12H17BrN2O2S In dichloromethane at 0℃; for 3h; Inert atmosphere;	90%

Upstream product

• 141573-95-7 ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate 
• 1086400-66-9 (Z)-2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoic acid ethyl ester 
• 60-34-4 methylhydrazine 
• 1089212-38-3 4-bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole 
• 201230-82-2 carbon monoxide 
• 1094484-55-5 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde 
• 851725-87-6 ethyl 3-(dichloromethyl)-1-methyl-1H-pyrazole-4-carboxylate 
• 1049772-84-0 3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonitrile 
• 53927-12-1 ethyl-3-(pyrrolidin-1-yl)prop-2-enoate 
• 1550-50-1 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine 
• 1001-26-9 ethyl 3-ethoxyacrylate 
• 34846-90-7 methyl 3-methoxyprop-2-enoate 
• 90608-65-4 3-piperidin-1-yl-acrylic acid methyl ester 
• 2925-22-6 2,2-difluoroacetyl fluoride 

Downstream Products

• 872121-94-3 N-(3',4'-dichlorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide 
• 1105713-20-9 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [1-methyl-2-(2,4,6-tribromo-phenoxy)-ethyl]amide 

Relevant articles and documents

PRODUCING METHOD FOR 3-DIFLUOROMETHYLPYRAZOLE COMPOUND, PRODUCING METHOD FOR 3-DIFLUOROMETHYLPYRAZOLE-4-CARBOXYLIC ACID COMPOUND, AND PYRAZOLIDINE COMPOUND

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The invention relates to a preparation method of a pyrazole derivative. The compound shown in the formula I reacts with a silanization reagent shown in a formula II to generate an intermediate productshown in a formula III, the intermediate product shown in the formula III reacts with a halogenated acid derivative shown in a formula IV to generate a halogenated compound shown in a formula V, andthe halogenated compound shown in the formula V reacts under acidic conditions to generate a pyrazole derivative shown in a formula VI. The preparation method of the pyrazole derivative is suitable for industrial production.

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate compounds, and preparation method and application thereof

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