108783-75-1

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 1011-51-4 5-(4-methoxyphenyl)-1,3-oxazole 
• 619-58-9 4-iodobenzoic acid 
• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 108783-61-5 N-[2-(4-Methoxy-phenyl)-2-oxo-ethyl]-terephthalamic acid methyl ester 
• 3883-94-1 2-amino-4'-methoxyacetophenone hydrochloride 
• 108783-68-2 2-(4-Carbomethoxyphenyl)-5-(4-methoxyphenyl)oxazole 

Downstream Products

• 108783-81-9 Acid Chloride of 2-(4-Carboxyphenyl)-5-(4-methoxyphenyl)oxazole 
• 108783-87-5 2-(4-Carbamidophenyl)-5-(4-methoxyphenyl)oxazole 

Relevant academic research and scientific papers

An efficient two-step synthesis of 2,5-disubstituted oxazole derivatives involving cu-promoted carbon-carbon single bond formation

Environment sensitive fluorescence probe to detect various organelles is emerging as an excellent tool to attract the attention of a large number of researchers around the globe. The recent developments have shown that oxazole dyes are very competent and can exhibit a useful fluorescence property in this direction. An efficient synthetic procedure towards 2,5-diaryl substituted oxazole derivatives have been reported. It is a two-step technique involving classical van Leusen protocol followed by copper-mediated coupling with aryl halides to introduce the required carbon-carbon single bond. The aryl groups are chosen in such a way so that the aryl functionalities at 2- and 5-positions of oxazole can act as acceptor and donor moiety respectively. Thus, in turn, the extended conjugation from donor moiety to acceptor moiety via the oxazole ring is set up therein. The oxazole derivatives were characterized by various spectroscopic measurements like NMR, IR and MS.

Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives

5-(4′-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity.

2,5-SUBSTITUTED OXAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER

Certain oxazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

SYNTHESIS AND SPECTRAL AND LUMINESCENT PROPERTIES OF 4-(5-ARYLOXAZOYL-2)BENZOIC ACIDS AND THEIR DERIVATIVES

Condensation of acid chloride of monomethyl terephtalate with ω-aminomethylarylketones and subsequent cyclodehydration of the resulting amides in sulfuric acid or phosphorus oxychloride give rise to methyl 4-(5-aryloxazolyl-2)benzoates which led to the co