109175-09-9

Basic information

• Product Name: 1H-Indole-3-carboxylic acid, 6-nitro-, methyl ester
• CAS NO: 109175-09-9
• Molecular Formula: C10H8N2O4
• Mol File: 109175-09-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Indole-3-carboxylic acid, 6-nitro-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-carboxylic acid, 6-nitro-, methyl ester(109175-09-9)
• EPA Substance Registry System: 1H-Indole-3-carboxylic acid, 6-nitro-, methyl ester(109175-09-9)

Safety Data

• Hazardous Substances Data: 109175-09-9(Hazardous Substances Data)

Usage

General Description

The chemical 1H-Indole-3-carboxylic acid, 6-nitro-, methyl ester is a derivative of indole, a heterocyclic compound commonly found in nature and used in the synthesis of various pharmaceuticals and agricultural chemicals. This specific compound contains a nitro group and a methyl ester, making it a nitro-indole derivative. Nitro-indole derivatives have been studied for their potential pharmacological and biological activities, including as anticancer, antimicrobial, and anti-inflammatory agents. The methyl ester group makes the compound more lipophilic and potentially more bioavailable, which could be advantageous for drug development. Overall, this compound is of interest in medicinal and agricultural chemistry for its potential biological and pharmacological properties.

Upstream product

• 10403-47-1 2-bromo 5-nitroaniline 
• 124-41-4 sodium methylate 
• 814-68-6 acryloyl chloride 
• 67-56-1 methanol 
• 10242-03-2 6-nitro-1H-indole-3-carboxylic acid 
• 771-50-6 1H-indole-3-carboxylic acid 
• 942-24-5 3-methoxycarbonylindole 

Downstream Products

• 10242-03-2 6-nitro-1H-indole-3-carboxylic acid 

Relevant articles and documents

Solid-phase synthesis of indolecarboxylates using palladium-catalyzed reactions

Polymer-supported, palladium-catalyzed cyclization reactions effectively synthesized indolecarboxylates. Palladium-catalyzed carbon - carbon bond-forming reactions of immobilized enaminoesters followed by transesterification yielded indole 2- or 3-carboxylates with various functional groups on the benzene ring. Indolecarboxylates were efficiently cyclized via an intramolecular palladium-catalyzed amination reaction of immobilized N-substituted dehydrohalophenylalanines, and immobilized N-acetyl-dehydroalanines were efficiently converted into indolecarboxylates via tandem Heck-amination reactions.

NEW SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS

The present invention relates to substituted arylsulphonylglycines of general formula (I) wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof, which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1 ), and their use as pharmaceutical compositions.