1848-46-0

Basic information

• Product Name: 2-BENZYL-1,2-DIHYDRO-INDAZOL-3-ONE
• Synonyms: 2-BENZYL-1,2-DIHYDRO-INDAZOL-3-ONE;2-Benzyl-2H-3-indolinone
• CAS NO: 1848-46-0
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.25788
• Mol File: 1848-46-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 390°Cat760mmHg
• Flash Point: 189.6°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 2.74E-06mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: 2-BENZYL-1,2-DIHYDRO-INDAZOL-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-1,2-DIHYDRO-INDAZOL-3-ONE(1848-46-0)
• EPA Substance Registry System: 2-BENZYL-1,2-DIHYDRO-INDAZOL-3-ONE(1848-46-0)

Safety Data

• Hazardous Substances Data: 1848-46-0(Hazardous Substances Data)

Usage

General Description

2-BENZYL-1,2-DIHYDRO-INDAZOL-3-ONE, also known as BDI, is a chemical compound that belongs to the class of indazoles. It is used in the synthesis of pharmaceuticals and agrochemicals, as well as in organic chemical reactions. BDI has a benzyl group attached to the 2-position of the indazole ring, giving it unique properties and reactivity. It is a versatile building block in organic synthesis due to its ability to undergo various chemical transformations, including oxidative addition, C-H activation, and cross-coupling reactions. BDI has a wide range of potential applications in medicinal and agricultural chemistry, making it a valuable compound in the field of chemical research and development.

InChI:InChI=1/C14H12N2O/c17-14-12-8-4-5-9-13(12)15-16(14)10-11-6-2-1-3-7-11/h1-9,15H,10H2

Upstream product

• 574757-80-5 2-(N'-benzyl-hydrazino)-benzoic acid 
• 29809-25-4 2-nitrosobenzaldehyde 
• 100-46-9 benzylamine 
• 552-16-9 ortho-nitrobenzoic acid 
• 52745-10-5 N-(phenylmethyl)-2-nitrobenzamide 
• 612-25-9 2-Nitrobenzyl alcohol 
• 85600-11-9 N-Benzylammonium-N'-benzylcarbaminat 
• 100-39-0 benzyl bromide 
• 16105-24-1 1-N-ethoxycarbonyl-3-hydroxy-1H-indazole 
• 100-52-7 benzaldehyde 
• 33906-30-8 2-hydrazinobenzoic acid hydrochloride 
• 4036-59-3 2-benzylidene-1-(2-carboxyphenyl)hydrazine 
• 7364-25-2 3-indazolinone 
• 16105-24-1 ethyl 2,3-dihydro-3-oxo-1H-indazole-1-carboxylate 

Downstream Products

• 109632-72-6 2-Benzyl-1-methyl-1,2-dihydro-indazol-3-one 

Relevant articles and documents

Claimed 2,1-benzisoxazoles are indazalones

(Chemical Equation Presented) Claims, by two groups, to have prepared 2,1-benzisoxazole derivatives are corrected to show that the products are indazalones (5). In addition, a simple preparation of 3-oxysubstituted 2H-indazole, by an unrecognized method i

Photocatalyst-free Synthesis of Indazolones under CO2 Atmosphere

A convenient photocatalyst-free method for the synthesis of redox-active 1,2-dihydro-3H-indazol-3-one derivatives from (2-nitroaryl)methanol and amines was developed. The reaction proceeded efficiently at room temperature by irradiation of UV light under CO2 atmosphere (1.0 atm, flow) without any photocatalysts or additives. This mild, operationally simple method shows wide functional tolerance. The carbamate formed in situ from CO2 and amine is proposed to be the key of this reaction. Some of these compounds synthesized by the present method were found to exhibit high anticancer activities, which can lower the viability of cancerous cell lines such as HeLa, MCF-7 and U87.

Photochemical Preparation of 1,2-Dihydro-3 H-indazol-3-ones in Aqueous Solvent at Room Temperature

o-Nitrosobenzaldehyde is a reactive intermediate useful in the synthesis of nitrogen heterocycles. Previous strategies for using o-nitrosobenzaldehyde involve its isolation via chromatography and/or formation under harsh conditions. Herein, this intermedi