109870-10-2

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 1026046-87-6 [(S)-3-(1-Benzyl-4-oxo-piperidin-3-yl)-1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-3-oxo-propyl]-carbamic acid benzyl ester 
• 1026594-26-2 (S)-4-(1-Benzyl-4-oxo-piperidin-3-yl)-2-benzyloxycarbonylamino-4-oxo-butyric acid 
• 919491-13-7 (E)-(1''S,3a''R,7a''S)-tert-butyl 3-[1'-benzyl-4'-(1''-tert-butoxy-7a''-methyl-2'',3'',3a'',6'',7'',7a''-hexahydro-1''H-indene-5''-yl)-1',2',5',6'-tetrahydropyridine-3'-yl]acrylate 
• 919491-10-4 1-benzyl-5-bromo-4-(1-tert-butoxy-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl)-1,2,3,6-tetrahydro-pyridine 
• 919491-07-9 1-benzyl 5-bromo-4-trifluromethanesulfonyloxy-1,2,3,6-tetrahydropyridine 
• 104860-16-4 1-benzyl-3-bromopiperidine-4-one 

Relevant academic research and scientific papers

A Solvent-Free Reaction for Silyl Enol Ethers Synthesis

Silyl enol ethers are extremely useful nucleophilic intermediates for chemical transformations because they are synthetically versatile substrates for a wide range of C-C bond-forming reactions. Here, we present a new, mild, and solvent-free procedure for the synthesis of silyl enol ethers that employs a catalytic amount of solid-supported base and an equimolar amount of N, O -(bistrimethylsilyl)acetamide as a silylating agent.

Design and asymmetric synthesis of β-strand peptidomimetics

We describe the asymmetric synthesis of non-peptidic compounds that feature rigid backbone conformations and present various side-chain functions. The key step in the synthesis of these compounds is the C-acylation of an appropriate ketone with a suitably protected aspartic acid derivative. The resulting dipeptide modules may be connected to form tetrapeptide mimics. Specifically is described the mimicry of a four-residue segment of CD4, the cellular receptor of HIV-1. The design was based on molecular modeling and the X-ray crystal structures of CD4 and intended to present the most important side chains and backbone elements of the Phe43-Lys46 segment.