109964-90-1

Upstream product

• 123023-88-1 1-benzylidene-2-(4,6-dimethylpyrimidin-2-yl)hydrazine 
• 23906-13-0 2-hydrazino-4,6-dimethylpyrimidine 
• 4472-44-0 2-chloro-4,6-dimethylpyrimidine 
• 29814-09-3 sodium salt of 5-phenyltetrazole 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 
• 108850-91-5 benzoic acid-[N'-(4,6-dimethyl-pyrimidin-2-yl)-hydrazide] 

Relevant academic research and scientific papers

Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines

[Figure not available: see fulltext.] Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which has very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine.

Utility of 2-hydrazino-4,6-dimethylpyridine in heterocyclic synthesis

2-Hydrazino-4,6-dimethylpyrimidine (1) readily underwent ring closure with benzoyl chloride to give 5,7-dimethyl-3 phenyl- 1,2,4-triazolo[4,3-a]pyrimidine (4a). Either N-benzoyl derivative (2) or the hydrazone (3a) can be used for formation of compound 4a. Reaction of compound 1 with acetylacetone gave the pyrazole derivative (6) rather than 1,2,4-triazepine derivative (5). The pyrrole (9) was the sole product from cyclization of 1 with 2,5 hexanedione. Reaction of compound 1 with carbon disulphide or ethyl chloroformate gave 1,2,4-triazolo[4,3-a]pyrimidines (10 and 12). The reaction of thiosemicarbazides (13 a-c) with ethyl bromoacetate and DCCD was investigated.