110210-17-8

Upstream product

• 1950-78-3 p-toluenesulfonyl iodide 
• 768-60-5 4-methoxyphenylacetylen 
• 1593-60-8 p-toluenesulfonylhydroxylamine 
• 14062-05-6 N,N'-ditosylhydrazine 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 2227-57-8 3-(4-methoxyphenyl)propynoic acid 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 696-62-8 para-iodoanisole 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 32291-91-1 p-Toluil-cis-p-methoxystyrylsulfon 

Relevant academic research and scientific papers

An efficient one-pot synthesis of vinyl sulphones via CAN mediated reaction of aryl sulphinates and alkenes

Cerium(IV) ammonium nitrate mediated reaction of sodium arene sulphinate and sodium iodide with alkenes afforded vinyl sulphones in very good yields.

An iodine-mediated new avenue to sulfonylation employingN-hydroxy aryl sulfonamide as a sulfonylating agent

A novel and highly efficient I2/K2CO3mediated regioselective sulfonylation of thiophenols, aryl acetylenic acid and aromatic alkynes withN-hydroxy sulfonamide has been developed.N-hydroxy sulfonamide has been used for the first time for the synthesis of these sulfones. The scope and versatility of the reaction has been demonstrated by the regio- and stereoselective synthesis of different analogs of sulfones with various structural features.

Iodosulfonylation of Alkynes under Ultrasound Irradiation

(E)-Iodo vinylsulfones are synthesized under ultrasound irradiation using alkynes, sulfonyl hydrazides, potassium iodide and hydrogen peroxide. The key features of this protocol are the speed and efficiency of the reactions, which afford good to excellent

Electrochemical Induced Regio- and Stereoselective Difunctionalization of Alkynes: The Synthesis of (E)-β-Iodovinyl Sulfones

An efficient, green, and oxidant-free electrochemical method for alkyne difunctionalization was described. Using undivided electrochemical cell for iodosulfonylation of alkynes with commercially available iodide radical (NaI), arylsulfonyl radical (ArSOs

Introduction of N,N'-disulfonylhydrazines as new sulfonylating reagents for highly efficient synthesis of (E)-β-iodovinyl arenesulfones under mild conditions

N,N'-Disulfonylhydrazines have been proven to be the most reactive precursors of the sulfonyl radicals among all types of sulfonyl substituted hydrazines as early as half a century ago. However, the sulfonyl radicals generated from these compounds have no

Iodine promoted iodosulfonylation of alkynes with sulfonyl hydrazides in an aqueous medium: Highly stereoselective synthesis of (E)-β-iodo vinylsulfones

A catalyst-free and metal-free sulfonylation reaction for the preparation of (E)-β-iodo vinylsulfones from alkynes with sulfonyl hydrazides and molecular iodine was efficiently developed under mild and environmentally benign conditions, in water without any ligand or catalyst. The reaction gave a range of structurally diverse β-iodo vinylsulfones with excellent E selectivities and high yields.

Synthetic method of beta-iodo-alkenyl sulfone compound

The invention discloses a synthetic method of a beta-iodo-alkenyl sulfone compound. The synthesis method comprises the following steps: mixing an alkyne derivative, a sulfonyl hydrazine derivative, iodine pentoxide and a solvent to obtain a mixed solution

Cobalt-catalyzed stereoselective iodosulfonylation and diiodination of alkynes via oxidation of potassium iodide in air

Cobalt-catalyzed iodosulfonylation of alkynes can be achieved using sodium sulfinates in the presence of KI. This procedure produces numerous stereoselective (E)-β-iodoalkenyl sulfones with good yields and suppresses the formation of diiodoalkenes. Furthermore, when this reaction is performed in the absence of sodium sulfinates, the expected (E)-diiodoalkenes are obtained.

Generation of β-Halo Vinylsulfones through a Multicomponent Reaction with Insertion of Sulfur Dioxide

A four-component reaction of terminal alkynes, aryldiazonium tetrafluoroborates, sulfur dioxide surrogate of DABCO?(SO2)2, and potassium halide in the presence of copper(I) chloride (10 mol %) gives rise to β-halo vinylsulfones with good stereoselectivity. The vicinal difunctionalization of alkynes through sulfonylation and halogenation with the insertion of sulfur dioxide works efficiently. A plausible mechanism is proposed, which includes a radical process.

Iodine-Catalyzed Facile Approach to Sulfones Employing TosMIC as a Sulfonylating Agent

A novel iodine-catalyzed functionalization of a variety of olefins and alkynes and direct decarboxylative functionalization of cinnamic and propiolic acids with TosMIC to provide access to various vinyl, allyl, and β-iodo vinylsulfones is described. This simple, efficient, and environmentally benign approach employing inexpensive molecular iodine as a catalyst demonstrates a versatile protocol for the synthesis of highly valuable sulfones, rendering it attractive to both synthetic and medicinal chemistry.