1104637-58-2

Usage

Uses

2-Pyridinylboronic Acid MIDA Ester can be used for HIV replication inhibitors.

Upstream product

• 109-04-6 2-bromo-pyridine 
• 4408-64-4 N-methyliminodiacetic acid 

Downstream Products

• 32111-34-5 4-(pyridine-2-yl)benzonitrile 
• 173681-56-6 1-(4-(pyridin-2-yl)phenyl)ethanone 
• 4467-06-5 2-(4-methylphenyl)pyridine 
• 10273-89-9 2-(2-methylphenyl)pyridine 
• 58861-53-3 4-fluorophenylpyridine 
• 1012310-87-0 2-(2,5-dimethylphenyl)pyridine 
• 4373-58-4 2-(3-methoxyphenyl)pyridine 
• 5957-89-1 2-(2-methoxy-phenyl)-pyridine 
• 117908-10-8 5-(2-pyridyl)indole 
• 109674-45-5 4-methyl-2,6-dioxo-8-phenylhexahydro-[1,3,2]oxazaborolo[2,3-b][1,3,2]oxazaborol-4-ium-8-uide 
• 1104637-47-9 isopropene boronic acid MIDA ester 
• 4408-64-4 N-methyliminodiacetic acid 
• 110-86-1 pyridine 
• 366-18-7 [2,2]bipyridinyl 

Relevant academic research and scientific papers

Methods for Forming Protected Organoboronic Acids

Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of building blocks, such as building blocks containing complex and/or pharmaceutically important structures, and/or provide simple or complex protected organoboronic acid building blocks. A first method includes reacting an imino-di-carboxylic acid and an organoboronate salt. A second method includes reacting a N-substituted morpholine dione and an organoboronic acid.

SLOW RELEASE OF ORGANOBORONIC ACIDS IN CROSS-COUPLING REACTIONS

A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1-B-T; where R1 represents an organic group, T represents a conformationalIy rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a pal ladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.

General method for synthesis of 2-heterocyclic N-methyliminodiacetic acid boronates

A wide range of 2-pyridyl and other difficult-to-access heterocyclic N-methyliminodiacetic acid boronates can be readily prepared from the corresponding bromides via a new method involving direct transligation of 2-heterocyclic trialkoxyborate salts with N-methyliminodiacetic acid (MIDA) at elevated temperatures.