110470-33-2Relevant academic research and scientific papers
X=Y=ZH systems as potential 1,3-dipoles. Part 62:1 1,3-Dipolar cycloaddition reactions of metallo-azomethine ylides derived from α-iminophosphonates
Dondas, H. Ali,Durust, Yasar,Grigg, Ronald,Slater, Martin J.,Sarker, Mohammed Abul Basher
, p. 10667 - 10682 (2005)
Metallo-azomethine ylides, generated from iminophosphonates in combination with LiBr or AgOAc and bases Et3N, DBU, t-butyl tetramethylguanidine(BTMG) undergo cycloaddition to give dialkyl pyrrolidine-2-phosphonates along with the corresponding
Simple and improved preparation α-aminophosphonic acid derivatives, key building blocks of phosphonopeptides
Takahashi,Yoshioka,Imai,Onimura,Kobayashi
, p. 763 - 764 (1994)
Strecker-type reaction of an aldehyde, ammonium acetate and diethyl phosphite in ethanol afforded the corresponding diethyl α-aminophosphonate, a key building block of the biologically interesting phosphonopeptides, in moderate to good yield.
Synthesis and cytotoxicity of O,O′-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates
Ning, Lihong,Wang, Wei,Liang, Yongju,Peng, Hao,Fu, Liwu,He, Hongwu
, p. 379 - 384 (2012/03/13)
A series of O,O′-dialkyl {[2-(substituted phenoxy)acetamido] (substituted phenyl)methyl}phosphonates was synthesized and their cytotoxic activities were tested against various human tumor cell lines. Some compounds (5q, 5r, 5s, 5w, 5x and 5y) showed relatively high cytotoxicity. Especially, compounds 5x and 5q exhibited the best cytotoxicity against KB and CNE2 cells with IC50 7.1 and 11.4 μM, respectively. Their inhibitory activities against KB and CNE2 cells were even higher than that of fluorouracil.
Synthesis and biological evaluation of novel phosphonates derivatives of as potential antitumor agents
Jin, Chuanfei,Liang, Yong-Ju,He, Hongwu,Fu, Liwu
, p. 2096 - 2103 (2011/12/01)
A series of dialkyl [2-(4,6-dimethoxypyrimidin-2-yloxy)benzamido](aryl) methylphosphonates derivatives were designed and synthesized. All the new compounds were identified by elemental analysis, IR, 1H NMR, 31P NMR, and MS. Their antitumor activity against KB and CNE1 cells was examined. Some of the compounds showed potential antitumor activity, which provided some hints for further study of structure modification. In particular, the compounds 6i and 6j displayed more potent cytotoxic activities against KB in comparison with 5-FU. Copyright Taylor & Francis Group, LLC.
A mild and highly efficient protocol for the one-pot synthesis of primary α-amino phosphonates under solvent-free conditions
Azizi, Najmedin,Rajabi, Fatemeh,Saidi, Mohammad R.
, p. 9233 - 9236 (2007/10/03)
Under solvent-free reaction conditions and in the presence of solid LiClO4 a novel and mild protocol for the one-pot, three-component synthesis of primary α-amino phosphonates from an aldehyde, hexamethyldisilazane and a trialkyl phosphite is described giving high yields and having short reaction times. The same products are obtained in very low yields, when the three-component reaction is carried out under microwave irradiation and in the absence of solid LiClO4. Examples of some prepared 1-aryl-N,N′-bis(arylidene)methanediamines are also described.
The synthesis of N-(β-triphenylgermanyl)-propionyl-α-amino-benzylphosphonates
Ye,Zeng,Liu
, p. 2373 - 2378 (2007/10/03)
A series of N-(β-triphenylgermanyl)propionyl-α-amino-benzylphosphonates was synthesized by reaction of β-triphenylgermanyl propionic acid with α-aminophosphonates under very mild conditions. The structures of products were determined by 1H NMR,
