Simple and improved preparation α-aminophosphonic acid derivatives, key building blocks of phosphonopeptides

Article abstract of DOI:10.1055/s-1994-25564

Strecker-type reaction of an aldehyde, ammonium acetate and diethyl phosphite in ethanol afforded the corresponding diethyl α-aminophosphonate, a key building block of the biologically interesting phosphonopeptides, in moderate to good yield.