Simple and improved preparation α-aminophosphonic acid derivatives, key building blocks of phosphonopeptides

DOI: 10.1055/s-1994-25564

Source and publish data:

Synthesis p. 763 - 764 (1994)

Update date:2022-08-18

Topics:

Authors:

Takahashi

Yoshioka

Imai Imai

Onimura Onimura

Kobayashi

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Article abstract of DOI:10.1055/s-1994-25564

Strecker-type reaction of an aldehyde, ammonium acetate and diethyl phosphite in ethanol afforded the corresponding diethyl α-aminophosphonate, a key building block of the biologically interesting phosphonopeptides, in moderate to good yield.

Full text of DOI:10.1055/s-1994-25564

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