110548-52-2

Basic information

• Product Name: Phosphonic acid, (aminophenylmethyl)-, dimethyl ester, (R)-
• CAS NO: 110548-52-2
• Molecular Formula: C9H14NO3P
• Molecular Weight: 215.189
• Mol File: 110548-52-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (aminophenylmethyl)-, dimethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (aminophenylmethyl)-, dimethyl ester, (R)-(110548-52-2)
• EPA Substance Registry System: Phosphonic acid, (aminophenylmethyl)-, dimethyl ester, (R)-(110548-52-2)

Safety Data

• Hazardous Substances Data: 110548-52-2(Hazardous Substances Data)

Upstream product

• 681035-60-9 O,O-dimethyl (R)-{[(1R)-2-hydroxy-1-phenylethyl]amino}(phenyl)methylphosphonate 
• 92-29-5 hydrobenzamide 
• 100-52-7 benzaldehyde 
• 96721-65-2 C₁₆H₁₈NO₃P 
• 59191-30-9 O,O-dimethyl {[(benzyloxy)carbonyl]amino}(phenyl)methylphosphonate 
• 71864-40-9 carbamic acid N-[(dimethoxyphosphinyl)phenylmethyl] 1,1-dimethylethyl ester 
• 681035-55-2 O,O-dimethyl (R)-{[(1R)-2-hydroxy-1-phenylethyl]amino}(phenyl)methylphosphonothioate 
• 74879-43-9 (R)-N-benzylidene-2-hydroxy-1-phenylethylamine 
• 868-85-9 Dimethyl phosphite 

Downstream Products

• 1347739-89-2 O,O-dimethyl [2-(4,6-dimethoxypyrimidin-2-yloxy)phenoxyamino](phenyl)methylphosphonate 
• 37714-05-9 (R)-1-amino-1-phenylmethylphosphonic acid 
• 1396320-40-3 O,O'-dimethyl-α-(thiazolo[5,4-b]pyridin-2-yl)amino(phenylmethyl)phosphonate 

Relevant articles and documents

Synthesis and cytotoxicity of O,O′-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates

A series of O,O′-dialkyl {[2-(substituted phenoxy)acetamido] (substituted phenyl)methyl}phosphonates was synthesized and their cytotoxic activities were tested against various human tumor cell lines. Some compounds (5q, 5r, 5s, 5w, 5x and 5y) showed relatively high cytotoxicity. Especially, compounds 5x and 5q exhibited the best cytotoxicity against KB and CNE2 cells with IC50 7.1 and 11.4 μM, respectively. Their inhibitory activities against KB and CNE2 cells were even higher than that of fluorouracil.

Synthesis of an optically active al(salalen) complex and its application to catalytic hydrophosphonylation of aldehydes and aldimines

Optically active aluminum(salalen) complex 2 was newly synthesized in a modular synthetic manner, and it was found to serve as an efficient catalyst for hydrophosphonylation of aldehydes and aldimines, giving the corresponding α-hydroxy and α-amino phosph

A mild and highly efficient protocol for the one-pot synthesis of primary α-amino phosphonates under solvent-free conditions

Under solvent-free reaction conditions and in the presence of solid LiClO4 a novel and mild protocol for the one-pot, three-component synthesis of primary α-amino phosphonates from an aldehyde, hexamethyldisilazane and a trialkyl phosphite is described giving high yields and having short reaction times. The same products are obtained in very low yields, when the three-component reaction is carried out under microwave irradiation and in the absence of solid LiClO4. Examples of some prepared 1-aryl-N,N′-bis(arylidene)methanediamines are also described.