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Upstream product

• 260-36-6 1-azaanthracene 
• 71-43-2 benzene 
• 98-86-2 acetophenone 
• 154845-34-8 3-amino naphthalene-2-carboxaldehyde 
• 104-54-1 3-Phenylpropenol 
• 91-59-8 naphthalen-2-ylamine 
• 141281-58-5 3-Amino-2-(hydroxymethyl)naphthalene 
• 98-85-1 1-Phenylethanol 
• 100-59-4 phenylmagnesium chloride 
• 19433-17-1 acetophenone O-acetyloxime 
• 300-57-2 allylbenzene 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 5959-52-4 2-Amino-3-naphthoic acid 
• 1207874-97-2 2-azido-3-(3-phenylprop-2-ynyl)naphthalene 

Relevant academic research and scientific papers

Unusual product distribution from Friedlaender reaction of Di-and triacetylbenzenes with 3-aminonaphthalene-2-carbaldehyde and properties of new benzo[g]quinoline-derived Aza-aromatics

The Friedlaender reactions of acetylbenzenes and 2-acetylpyridine with 3-aminonaphthalene-2-carbaldehyde afforded the corresponding 2-phenylbenzo[g]quinoline and 2-(pyrid-2-yl)benzo[g]quinoline, respectively. The same reactions of 3-aminonaphthalene-2-carbaldehyde with 1,2-, 1,3-, 1,4-di- and 1,3,5-triacetylbenzenes, however, afforded a series of corresponding (benzo[g]quinolin-2-yl)benzenes as new N,C-bidentate and unexpected benzo[g]quinoline. Crystallinity, thermal properties, absorption and emission spectral properties of the products were studied.

Near-infrared-emitting iridium(III) complexes as phosphorescent dyes for live cell imaging

The three near-infrared-emitting cationic iridium(III) complexes [Ir(pbq-g)2(NaN)]+PF 6- (pbq-g = phenylbenzo[g]quinoline; N aN = bipyridine (1), 1,10-phenanthroline (2), 4,7-diphenyl-1,10-phenanthroline (3)) have been demonstrated as phosphorescent dyes in live cell imaging. These complexes with different ancillary ligands show similar near-infrared (NIR) emission with λmax,peak at 698 nm and λmax,shoulder at 760 nm in CH2Cl2 solutions, with a moderate quantum yield of around 3%. However, these complexes behave quite differently as NIR dyes for live cell imaging. Complexes 1 and 2 exhibit exclusive staining in the cytoplasm with good cell membrane permeability under excitation at 488 nm, while 3 gives almost no cell uptake, as further determined by flow cytometry. Although the lipophilicities of these complexes follow the order 1 a key role in the design of NIR-emitting iridium(III) complexes for practical applications in bioimaging.

Near-infrared emission electrostimulation response type iridium (III) complex as well as preparation method and application thereof

The invention discloses a near-infrared emission electrostimulation response type iridium (III) complex and a preparation method and application thereof, wherein the iridium (III) complex is formed by combining a cyclometalC ^ ^ N ligand with a large conj

Modular Access to Spiro-dihydroquinolines via Scandium-Catalyzed Dearomative Annulation of Quinolines with Alkynes

The catalytic enantioselective construction of three-dimensional molecular architectures from planar aromatics such as quinolines is of great interest and importance from the viewpoint of both organic synthesis and drug discovery, but there still exist many challenges. Here, we report the scandium-catalyzed asymmetric dearomative spiro-annulation of quinolines with alkynes. This protocol offers an efficient and selective route for the synthesis of spiro-dihydroquinoline derivatives containing a quaternary carbon stereocenter with an unprotected N-H group from readily accessible quinolines and diverse alkynes, featuring high yields, high enantioselectivity, 100% atom-efficiency, and broad substrate scope. Experimental and density functional theory studies revealed that the reaction proceeded through the C-H activation of the 2-aryl substituent in a quinoline substrate by a scandium alkyl (or amido) species followed by alkyne insertion into the Sc-aryl bond and the subsequent dearomative 1,2-addition of the resulting scandium alkenyl species to the C=N unit in the quinoline moiety. This work opens a new avenue for the dearomatization of quinolines, leading to efficient and selective construction of spiro molecular architectures that were previously difficult to access by other means.

Mild and efficient copper-catalyzed oxidative cyclization of oximes with 2-aminobenzyl alcohols at room temperature: synthesis of polysubstituted quinolines

A simple and efficient ligand-free Cu-catalyzed protocol for the synthesis of polysubstituted quinolinesviaoxidative cyclization of oxime acetates with 2-aminobenzyl alcohols at room temperature has been developed. The presented approach provides a new synthetic pathway leading to polysubstituted quinolines with good functional group tolerance under mild conditions. Moreover, this transformation can be applied for the preparation of quinolines on a gram scale. Oxime acetates serve as the internal oxidants in the reactions, thus making this method very attractive.

Visible-Light-Mediated Oxidative Cyclization of 2-Aminobenzyl Alcohols and Secondary Alcohols Enabled by an Organic Photocatalyst

This paper describes a visible-light-mediated oxidative cyclization of 2-aminobenzyl alcohols and secondary alcohols to produce quinolines at room temperature. This photocatalytic method employed anthraquinone as an organic small-molecule catalyst and DMSO as an oxidant. According to this present procedure, a series of quinolines were prepared in satisfactory yields.

Dehydrogenative Synthesis of Quinolines, 2-Aminoquinolines, and Quinazolines Using Singlet Diradical Ni(II)-Catalysts

Simple, straightforward, and atom economic methods for the synthesis of quinolines, 2-aminoquinolines, and quinazolines via biomimetic dehydrogenative condensation/coupling reactions, catalyzed by well-defined inexpensive and easy to prepare singlet diradical Ni(II)-catalysts featuring two antiferromagnetically coupled singlet diradical diamine type ligands are described. Various polysubstituted quinolines, 2-aminoquinolines, and quinazolines were synthesized in moderate to good yields from different low-cost and readily accessible starting materials. Several control experiments were carried out to get insight into the reaction mechanism which shows that the nickel and the coordinated diamine ligands participate in a synergistic way during the dehydrogenation of alcohols.

A nickel catalyzed acceptorless dehydrogenative approach to quinolines

A general, efficient and environmentally benign, one-step synthesis of substituted quinoline derivatives was achieved by acceptorless dehydrogenative coupling of o-aminobenzylalcohols with ketones and secondary alcohols catalyzed by a cheap, earth abundant and easy to prepare nickel catalyst [Ni(MeTAA)], featuring a tetraaza macrocyclic ligand (tetramethyltetraaza[14]annulene (MeTAA)). A wide variety of substituted quinolines were synthesized in high yields starting from readily available o-aminobenzylalcohols and ketones or secondary alcohols. A few controlled reactions were carried out to establish the acceptorless dehydrogenative nature of the reactions.

Palladium-catalyzed synthesis of quinolines from allyl alcohols and anilines

A process for quinoline synthesis through palladium-catalyzed oxidative cyclization of aryl allyl alcohols and anilines is described. This process works in the absence of acid, base and any other additive and has a broad substrate scope, tolerating electron-withdrawing groups such as nitryl, trifluoromethyl and so on. A series of quinolines are prepared in satisfactory yields.

A aryl heterocyclic compound and its preparation method and a kind of organic electroluminescent device (by machine translation)

This invention has offered a kind of aromatic heterocyclic compound, the structure shown in formula (I). This invention is in the benzo [g] quinoxaline, benzo [g] quinoline and benzo [g] isoquinoline, and the like to introduce the structure R 1, R 2, R 3, electron density can be improved, to improve compound performance skills and upward, thus the formula (I) shown in a very good Arylheterocycle compound can be used as the electron transport material is applied, to its preparation of the organic electroluminescent light-emitting device with higher brightness, good heat resistance, long life and high luminous efficiency, and the like. (by machine translation)