111-73-9

Usage

Uses

Used in Chemical Industry:
4-ethoxybutan-1-ol is used as a solvent for its ability to dissolve a wide range of substances, making it suitable for the production of lacquers, varnishes, and dyes.
Used in Pharmaceutical Industry:
4-ethoxybutan-1-ol is used as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new medications and therapeutic agents.
Used in Organic Compounds Synthesis:
4-ethoxybutan-1-ol is utilized as a building block in the synthesis of other organic compounds, facilitating the creation of diverse chemical products.
Safety Precautions:
It is crucial to handle 4-ethoxybutan-1-ol with care due to its potential harmful effects if ingested, inhaled, or in contact with the skin or eyes. It should be stored and used in well-ventilated areas and with appropriate protective equipment to ensure the safety of individuals working with this chemical.

InChI:InChI=1/C6H14O2/c1-2-8-6-4-3-5-7/h7H,2-6H2,1H3

Upstream product

• 109-99-9 tetrahydrofuran 
• 64-17-5 ethanol 
• 26448-91-9 4-ethoxy-butyric acid ethyl ester 
• 33691-62-2 3-bromo-2-ethoxy-tetrahydro-furan 
• 74-96-4 ethyl bromide 
• 110-63-4 Butane-1,4-diol 
• 75-03-6 ethyl iodide 
• 4469-25-4 2-methyl-[1,3]dioxepane 
• 557-31-3 3-ethoxyprop-1-ene 
• 201230-82-2 carbon monoxide 
• 50-00-0 formaldehyd 
• 29006-04-0 4-ethoxy-butyric acid methyl ester 

Downstream Products

• 60905-39-7 butylene glycol monoethyl ether acetate 
• 29006-04-0 4-ethoxy-butyric acid methyl ester 
• 84629-07-2 7-Ethoxy-1-phenyl-1,4-heptandion 
• 70160-08-6 6-Ethoxycapronsaeure 
• 2260-44-8 1-(4-ethoxy-butyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester 
• 90724-84-8 6-Ethoxy-2-methyl-hexanol-(2) 

Relevant academic research and scientific papers

2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS

Compounds which are 2-amino-1,3-thiazole derivatives of formula (I) wherein R is a halogen atom, a nitro group, an optionally substituted amino group or it is a group, optionally further substituted, selected from i) straight or branched C1-C8 alkyl, C2-C6 alkenyl or C2-C6 alkynyl; ii) C3-C6 cycloalkyl; iii) aryl or arylalkyl with from 1 to 8 carbon atoms within the straight or branched alkyl chain; R1 is an optionally further substituted group selected from: i) straight or branched C1-C8 alkyl or C2-C6 alkenyl; ii) 3 to 6 membered carbocycle or 5 to 7 membered heterocycle ring; iii) aryl or arylcarbonyl; iv) arylalkyl with from 1 to 8 carbon atoms within the straight or branched alkyl chain; v) arylalkenyl with from 2 to 6 carbon atoms within the straight or branched alkenyl chain; vi) an optionally protected amino acid residue; or a pharmaceutically acceptable salt thereof; are useful for treating cell proliferative disorders associated with an altered cell dependent kinase activity.

Synthesis and antiproliferative activity of alkylphosphocholines

Alkylphosphocholines (APC) with one or more methylene groups in the alkyl chain replaced by oxygen atoms or carbonyl groups, or both have been assembled modularly using ω-diols as central building blocks. Out of 25 new compounds of this kind, 11 were evaluated for their antiproliferative activity on four cell lines and compared with miltefosine to evaluate their hemolytic activity (HA) and cytotoxicity on non-tumoral cells (MT2), used as markers of adverse effects. Compound 13 was more active on cancer cell lines than on non-tumoral cells and the data were similar for MTT and thymidine incorporation assays. It had less HA than miltefosine. Compound 13 could therefore be a candidate for the preparation of compounds with higher cytotoxicity on cancer cells and lower general toxicity.

Hydrocarbonylation of prop-2-en-1-ol to butane-1,4-diol and 2-methylpropan-1-ol catalysed by rhodium triethylphosphine complexes

The hydrocarbonylation of prop-2-ene-1-ol catalysed by [Rh2(O2CMe)4]-PEt3, which gives [RhH(CO)(PEt3)2] as the active species, has been found to produce predominantly butane-1,4-diol and 2-methylpropan-1-ol with small amounts of 2-methylpropane-1,3-diol and propan-1-ol. Neither 2-methylprop-2-enal nor 2-methylprop-2-en-1-ol are intermediates in the production of 2-methylpropan-1-ol. By carrying out the reaction under a variety of reaction conditions and by using deuterium-labelling studies it was possible to formulate a mechanism for the production of 2-methylpropan-1-ol which involves formation of the vinyl alcohol, 2-methylprop-1-en-1-ol, as the primary product followed by tautomerism and hydrogenation, provided that at least two PEt3 groups are co-ordinated to the rhodium. A dehydration is proposed to occur during the catalytic cycle from a cationic hydroxycarbene intermediate. Using propenyl ethers as substrates similar products are obtained presumably via loss of alcohol rather than dehydration. If less than two PEt3 groups are co-ordinated to rhodium the major branched-chain product from prop-2-en-1-ol is 2-methylpropane-1,3-diol. This is interpreted as indicating that protonation of the acyl intermediate and dehydration of the hydroxycarbene do not occur because of the lower electron density on the acyl O atom.

Isomerization and Hydrogenolysis of 1,3-Dioxacycloalkanes on Metal Catalysts

The isomerization of 5-, 6-, and 7-membered 1,3-dioxacycloalkanes to esters on various metal catalysts is reported, the hydrogenolysis pattern for this type of compound is determined, and a new reaction mechanism is proposed to interpret these catalytic processes.