111008-23-2Relevant academic research and scientific papers
Dehydroacetic acid, precursor of benzodiazepine synthesis
El Abbassi,Djerrari,Essassi,Fifani
, p. 7069 - 7070 (2007/10/02)
Reaction of o-phenylenediamine 1 with dehydracetic acid 2 in different alcohols leads to 2-alkoxycarbonylmethyl 4-methyl 1,5-benzodiazepines 3-7, to 4-acetyl methylene 1,5-benzodiazepin-2-one 8, and to benzimidazoles 9 and 10. This constitutes a novel and efficient synthesis of some benzodiazepine derivatives.
NOUVELLE SYNTHESE DES BENZODIAZEPINES-1,5 A PARTIR DE LA γ-PYRONE
Abbassi, M. El,Essassi, E. M.,Fifani, J.
, p. 1389 - 1392 (2007/10/02)
Reaction of o-phenylenediamines 2, 3 with 2-hydroxy-6-methyl-4-pyrone leads to: 2-butoxycarbonylmethylene-4-methyl-1,5-benzodiazepines 4, 5, 4-acetylmethylene-1,5-benzodiazepin-2-ones 6, 7, and benzimidazoles 8, 11.These compounds result from competitive reactions and different ways of cyclization.
