1112-96-5

Upstream product

• 110-57-6 trans-1,4-dichlorobut-2-ene 
• 122-52-1 triethyl phosphite 
• 821-06-7 (E)-1,4-dibromobutene 
• 6974-12-5 1,4-dibromo-2-butene 
• 764-41-0 1,4-dichloro-2-butene 
• 1067-87-4 Diethyl allylphosphonate 

Downstream Products

• 89510-72-5 (E,E,E)-1,6-bis(4-nitrophenyl)hexa-1,3,5-triene 
• 25229-66-7 1.1.6.6-Tetraphenyl-hexatrien-1.3.5 
• 89549-25-7 3,3',4,4,4',4',5,5'-Octamethyl-1,1'-(2-buten-4,1-diylidene)bis(2,5-cyclohexadien) 
• 90580-91-9 3,3',4,4,4',4',5,5'-Octamethyl-1,1'-(2,4,6-octatrien-8,1-diyliden)bis(2,5-cyclohexadien) 
• 23429-43-8 1,6-di(4-chlorophenyl)hexa-1,3,5-triene 
• 5056-17-7 (2E,4E,6E)-2,7-dimethyl-2,4,6-octatrienedial 
• 1443299-36-2 (1E,3E,5E)-1,6-bis(3,4,5-trimethoxyphenyl)hexa-1,3,5-triene 
• 1443299-35-1 (1E,3E,5E)-1,6-bis(2,4-dimethoxyphenyl)hexa-1,3,5-triene 
• 70022-70-7 (1E,3E,5E)-1,6-bis(3,4-dimethoxyphenyl)hexa-1,3,5-triene 

Relevant academic research and scientific papers

Configurational and Conformational Isomeric Paratropic, Rotational Dynamic Tetraepoxyannulenes(6.2.6.2) and Diatropic Tetraoxaporphyrin(6.2.6.2) Dications: Detection of a Tetraepoxyannulene(6.2.6.2) Radical Cation

The synthesis of tetraepoxyannulenes(6.2.6.2) (4) by a cyclizing twofold Wittig reaction of (E,E,E)-5,5'-(hexa-1,3,5-triene-1,6-diyl)bis (6) and the corresponding bis-phosphonium salt 7 is described. Contrary to the configuration

Synthesis of biphenyltrienes as probes for β-amyloid plaques

We report a series of p-hydroxy-, p-amino-, p-monomethylamino-, and p-monofluoroethylamino-substituted biphenyltrienes that displayed high binding affinities to β-amyloid plaques. In an in vitro binding assay using postmortem brain homogenates of Alzheime

BIS PHENYL HEXA TRIEN DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR SKIN WHITENING CONTAINING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to a bis phenyl hexa triene derivative, a preparation method thereof and a composition for skin whitening comprising the same as an active ingredient. The said derivative inhibits the expression of tyrosinase, TRP 1 (tyrosina

BIPOLAR TRANS CAROTENOID SALTS AND USES THEREOF

PROBLEM TO BE SOLVED: To provide compounds useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans. SOLUTION: There is provided a compound which has a structure represented by YZ-TCRO-ZY and is not trans sodium crocetinate [where, Y is a cation; Z is a polar group which is associated with the cation; and TCRO is trans carotenoid skeleton], and preferably, Y is a monovalent metal ion selected from the group consisting of Na+, K+ and Li+, or is an organic cation selected from the group consisting of R4 N+ and R3S+ [R is H, or CnH2n+1(n is 1 to 10)]. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT

TRIARYLAMINE HYDRAZONE COMPOUND AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR

PROBLEM TO BE SOLVED: To provide a compound that improves the electric characteristics of electrophotographic photoreceptors. SOLUTION: A triarylamine hydrazone compound is represented by formula (1) (R1-R6 independently represent halogen, a substituted/unsubstituted C1-6 alkyl group, a C1-6 alkoxy group or a substituted/unsubstituted C6-14 aryl group; a is an integer of 1 to 3 or less; b and c independently represent 0 or 1; d, e, f, g, h and i independently represent an integer of 0-5). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2017,JPOandINPIT

TRIARYLAMINE HYDRAZONE COMPOUND AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR

PROBLEM TO BE SOLVED: To provide a compound that improves the electric characteristics of electrophotographic photoreceptors. SOLUTION: A triarylamine hydrazone compound is represented by general formula (1) (R1-R6 independently represent a halogen atom, a substituted/unsubstituted C1-6 alkyl group, a substituted/unsubstituted C1-6 alkoxy group or a substituted/unsubstituted C6-14 aryl group; a is an integer of 1 to 3 or less; b-g independently represent an integer of 0-5). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2017,JPOandINPIT

TRIARYLAMINE DERIVATIVE, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR

PROBLEM TO BE SOLVED: To provide a triarylamine derivative which allows an electrophotographic photoreceptor to be produced. SOLUTION: A triarylamine derivative is represented by, for example, formula (1). (R1 and R2 are the same or different and each selected from the group consisting of a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C1-6 alkoxy group and an optionally substituted C6-12 aryl group. k and l are each an integer of 0-4; m and n are each an integer of 1-3.) SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPOandINPIT

Synthesis of labile all-trans-7,8,7′,8′-bis-acetylenic carotenoids by bi-directional Horner-Wadsworth-Emmons condensation

A new stereoselective synthesis of the C40-bis-acetylenic carotenoids all-trans-(3R,3′R)-alloxanthin and all-trans-3,4,7,8,3′,4′,7′,8′-octadehydro-β,β-carotene, both compounds featuring a stereochemically labile C7-C10 enyne, based on a bi-directional Horner-Wadsworth-Emmons (HWE) reaction of a C15-phosphonate and a central C10-dialdehyde, is reported. The triene unit of the latter fragment was synthesized using the acyclic metathesis/dimerization reaction.

Synthesis and characterization of quantum dot nanoparticles bound to the plant volatile precursor of hydroxy-apo-10′-carotenal

This study is focused on the synthesis and characterization of hydroxy-apo-10′-carotenal/quantum dot (QD) conjugates aiming at the in vivo visualization of β-ionone, a carotenoid-derived volatile compound known for its important contribution to the flavor and aroma of many fruits, vegetables, and plants. The synthesis of nanoparticles bound to plant volatile precursors was achieved via coupling reaction of the QD to C27- aldehyde which was prepared from α-ionone via 12 steps in 2.4% overall yield. The formation of the QD-conjugate was confirmed by measuring its fluorescence spectrum to observe the occurrence of fluorescence resonance energy transfer.

Molecular docking studies of (1E,3E,5E )-1,6-bis(substituted phenyl)-hexa-1,3,5-triene and 1,4-bis(substituted trans-styryl)benzene analogs as novel tyrosinase inhibitors

We simulated the docking of the tertiary structure of mushroom tyrosinase with our compounds. From the structure-tyrosinase inhibitory activity relationship, it is notable that compounds 4, 8 and 11 showed similar or better activity rates than kojic acid which was used as a positive control. Compounds 17, 21, and 23 among benzene analogs that possess the same substituent showed significantly lower tyrosinase inhibitory effects. Therefore, we have confirmed that among the compounds showing better tyrosinase inhibitory effects than kojic acid, the compounds with triene analogs have better tyrosinase inhibitory effect than the compounds with benzene analogs. Docking simulation suggested the mechanism of compounds by several key residues which had possible hydrogen bonding interactions. The pharmacophore model underlined the features of active compounds, 4,4′-((1E,3E,5E )-hexa-1,3,5-triene-1,6-diyl)diphenol, 5,5′-((1E,3E,5E )-hexa-1,3,5-triene-1,6-diyl)bis(2-methoxy-phenol), and 5,5′-((1 E,3E,5E )-hexa-1,3,5-triene-1,6-diyl)dibenzene-1,3-diol among triene derivatives which had several hydrogen bond groups on both terminal rings. The soundness of the docking results and the agreement with the pharmacophores suggest that it can be conveniently exploited to design inhibitors with an improved affinity for tyrosinase.