117833-60-0

Basic information

• Product Name: a-Bromo-N-Boc-Gly-OtBu
• Synonyms: a-Bromo-N-Boc-Gly-OtBu;Alfa-Bromo-N-Boc-Gly-OtBu;Acetic acid,2-broMo-2-[[(1,1-diMethylethoxy)carbonyl]aMino]-, 1,1-diMethylethyl ester;broMo(tert-butoxycarbonylaMino)acetic acid tert-butyl ester;tert-Butyl 2-bromo-2-((tert-butoxycarbonyl);tert-butyl 2-bromo-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
• CAS NO: 117833-60-0
• Molecular Formula: C₁₁H₂₀BrNO₄
• Molecular Weight: 310.1848
• Mol File: 117833-60-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 55℃
• Boiling Point: 337.8±32.0 °C(Predicted)
• Appearance: /
• Density: 1.294±0.06 g/cm3(Predicted)
• PKA: 9.16±0.46(Predicted)
• CAS DataBase Reference: a-Bromo-N-Boc-Gly-OtBu(CAS DataBase Reference)
• NIST Chemistry Reference: a-Bromo-N-Boc-Gly-OtBu(117833-60-0)
• EPA Substance Registry System: a-Bromo-N-Boc-Gly-OtBu(117833-60-0)

Safety Data

• Hazardous Substances Data: 117833-60-0(Hazardous Substances Data)

Usage

General Description

a-Bromo-N-Boc-Gly-OtBu, also known as N-Boc-glycine alpha-bromoisobutyryl ester, is a chemical compound widely used in organic synthesis. It is a derivative of N-Boc-glycine and is commonly used as a building block for the preparation of various pharmaceuticals and biologically active compounds. The Boc (tert-butoxycarbonyl) protecting group allows for selective manipulation of the amino group, making it a valuable intermediate in peptide synthesis. The alpha-bromo substitution enhances the reactivity of the compound, making it a versatile and useful building block for the synthesis of a wide variety of complex organic molecules.

Upstream product

• 111652-20-1 N-(tert-butoxycarbonyl)glycine tert-butyl ester 
• 27532-96-3 glycine tert-butyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 119768-56-8 t-butyl 2-(t-butoxycarbonylamino)-2-(1-hydroxy-5,5-dimethyl-3-oxocyclohexen-2-yl)acetate 
• 119768-66-0 t-butyl 2-(t-butoxycarbonylamino)-4-oxo-3-(oxophenylmethyl)pentanoate 
• 111717-08-9 t-butyl 2-(t-butoxycarbonylamino)-4-oxo-4-phenylbutanoate 
• 111652-16-5 (S)-tert-Butoxycarbonylamino-((S)-2-oxo-cyclohexyl)-acetic acid tert-butyl ester 
• 111652-11-0 tert-Butoxycarbonylamino-p-tolyl-acetic acid tert-butyl ester 
• 111652-10-9 tert-Butoxycarbonylamino-phenyl-acetic acid tert-butyl ester 
• 111652-08-5 2-tert-Butoxycarbonylamino-4-phenyl-butyric acid tert-butyl ester 
• 111652-12-1 tert-Butoxycarbonylamino-(4-methoxy-phenyl)-acetic acid tert-butyl ester 

Relevant articles and documents

A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe

An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled

PYRROLOPYRAZINE DERIVATIVES AS SYK AND JAK INHIBITORS

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula (I), wherein the variables Q and R1 and R2 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Catalytic, asymmetric Mannich-type reactions of α-imino esters bearing readily removable substituents on nitrogen

(Matrix presented) Catalytic, enantioselective Mannich-type reactions of α-imino esters bearing readily removable substituents on nitrogen are described. Several N-carbamate-protected α-imino esters, which are readily prepared from 2-bromoglycine esters using a polymer-supported amine, reacted with silicon enolates to afford the desired adducts in high yields with high enantioselectivity using a copper(II)-diamine complex. Easy deprotection of the product amine and transformation to free o-amino acid derivatives have also been demonstrated.