111766-71-3Relevant academic research and scientific papers
RAPAMYCIN ANALOGS AND USES THEREOF
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Paragraph 00455; 00457-00459, (2020/01/08)
The present invention provides compounds, compositions thereof, and methods of using the same.
An iterative acetylene-epoxide coupling strategy for the total synthesis of longimicin C
He, Yan-Tao,Xue, Song,Hu, Tai-Shan,Yao, Zhu-Jun
, p. 5393 - 5397 (2007/10/03)
Longimicin C, a naturally occurring annonaceous acetogenin possessing a C2-symmetrical bis-THF moiety and a short hydrocarbon chain between its THF-containing region and a terminal γ-lactone, was synthesized for the first time. The total synthe
SYNTHESIS AND CONFORMATIONS OF 2,3:4,5- AND 2,4:3,5-DI-O-ISOPROPYLIDENE-D-MANNITOL
Gawronska, Krystyna
, p. 79 - 86 (2007/10/02)
The 2,3:4,5- (8) and 2,4:3,5-di-O-isopropylidene (10) derivatives of D-mannitol have been prepared from 1,6-di-O-benzoyl-D-mannitol and their structures established by (13)C-n.m.r. spectroscopy.The 1,3-dioxane rings in 10 adopt a skew conformation and the sugar carbon chain in 8 is bent around the C-3-C-4 bond, as found by i.r. data and molecular mechanics calculations.Oxidation of 8 with pyridinium dichromate gave 2,3:4,5-di-O-isopropylidene-D-mannono-1,6-lactone (12).
Chiral Ligands for Organometallic Catalysis containing Two Dioxolane Rings
Brown, John M.,Dayrit, Fabian M.,Sinou, Denis
, p. 91 - 96 (2007/10/02)
Treatment of D-mannitol 1,6-dibenzoate with a catalytic quantity of toluene-p-sulphonic acid in 2,2-dimethoxypropane leads to the formation of two cyclic acetals, 4R,8R,9R,10R-2,2',6,6'-tetramethyl-4,8-bis(benzoyloxymethyl)-1,3,5,7-tetraoxadecalin and R,R'-4,4'-bi-(2,2-dimethyl-5-benzoyloxymethyldioxolanyl) in comparable amounts.Successive reaction with sodium methoxide in methanol, methanesulphonyl chloride, and lithium or potassium diphenylphosphide gave the corresponding phosphines namely 4S,8S,9S,10S-2,2',6,6'-tetramethyl-4,8-di-1,3,5,7-tetraoxadecalin and S,S-4,4'-bi-.Similarly, starting from L-iditol, the diphosphines 4R,8S,9S,10R-2,2',6,6'-tetramethyl-4,8-di-1,3,5,7-tetraoxadecalin and S,R-4,4'-bi- were obtained.It was demonstrated through (31)P n.m.r. studies that both cis- and trans-chelate complexes of rhodium were formed by these biphosphine ligands.Their potential in asymmetric hydrogenation was demonstrated, for low to moderate yields of amino acids were formed from a variety of enamide precursors.
