111960-27-1Relevant articles and documents
A rapid, solvent-free, ligandless and mild method for preparing aromatic ketones from acyl chlorides and arylboronic acids via a Suzuki-Miyaura type of coupling reaction
Bandgar,Patil
, p. 7627 - 7630 (2005)
Aromatic ketones were synthesized via a palladium catalyzed cross-coupling reaction of boronic acids with acyl chlorides in the presence of Na 2CO3 at room temperature under solvent-free conditions. The ligand-free and mild reaction conditions, highly rapid reaction rate and good to excellent yields are important features of this method.
Design, synthesis, and evaluation of 9-(pyrimidin-2-yl)-9H-carbazole derivatives disrupting mitochondrial homeostasis in human lung adenocarcinoma
Chen, Yue-Ru,Li, Kun-Tao,Ou, Tian-Miao,Su, Xiao-Xuan,Sun, Jia-Wei,Wang, Honggen,Wang, Xiao-Na,Wu, Jia-Qiang,Wu, Xiong-Zhi
, (2022/02/25)
Since more than 85% of lung cancer cases are non-small cell lung cancer (NSCLC), finding novel agents with anti-tumor activities is meaningful for NSCLC patients. Mitochondria is essential for cellular energy metabolism in cancer, and regulating mitochondrial bioenergetics is emerging as a practical approach for cancer treatment and prevention. The carbazole scaffold is an active structure showing anti-cancer biological activity, and the structural diversity has been expanded through the improvement and optimization of synthesizing methods. To find novel carbazole derivatives with great anti-tumor potential and explore structures variety, we designed and synthesized a series of 9-(pyrimidin-2-yl)-9H-carbazole derivatives based on the previously reported Cp?Rh(III)/H+ tandem catalytic system. With thoroughly bioactivity exploration, we found benzo[d] [1,3]dioxol-5-yl(9-(pyrimidin-2-yl)-9H-carbazol-1-yl)methanone (compound 5n) showed notable activity in disrupting the mitochondrial homeostasis, induced cell cycle arrest and apoptosis in human adenocarcinoma cells, and finally showed anti-tumor activity in an NSCLC-xenograft mice model.
STUDIES ON ENAMIDES PART-2 : A NOVEL PHOTOCHEMICAL SYNTHESIS OF 9H-INDOLOPHENANTHRIDIN-9-ONE, A BENZCANTHINE ANALOGUE
Ghosh, Somnath,Datta, Diptendu Bhusan,Datta, Indira,Das, Tapas Kumar
, p. 3775 - 3786 (2007/10/02)
The synthesis of 3-aroylcarbazoles and the unknown 1-aroylcarbazoles has been achieved by the photolysis of 9-aroylcarbazoles in polar solvent.Irradiation of 3(a-c) in non-polar solvent afforded regiospecifically 5(a-c), carbazole (1) and for the first time, 9H-indolophenanthridin-9-one (8) from 3b.The yield of 8 was significantly improved by UV exposure of 9-(2-iodobenzoyl)-carbazole (3e) in methanol and iodine, without providing any photomigrated product.
