112182-50-0

Usage

InChI:InChI=1/C15H10ClNO/c16-11-6-7-13-12(8-11)15(18)9-14(17-13)10-4-2-1-3-5-10/h1-9H,(H,17,18)

Upstream product

• 86397-94-6 β-(4-chloro-anilino)-cinnamic acid ethyl ester 
• 112182-56-6 5-[(4-Chloro-phenylamino)-phenyl-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 75-15-0 carbon disulfide 
• 141-82-2 malonic acid 
• 106-47-8 4-chloro-aniline 
• 41019-23-2 benzoic acid-(2-acetyl-4-chloro-anilide) 
• 1200055-89-5 C₁₅H₁₀ClNO 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 100865-38-1 methyl 2-benzamido-5-chlorobenzoate 
• 19407-45-5 2-benzamido-5-chlorobenzoic acid 
• 7033-51-4 6-chloro-2-phenyl-benzo[d][1,3]oxazin-4-one 

Relevant academic research and scientific papers

Microwave-assisted rapid and straightforward synthesis of 2-aryl-4-quinolones from acylated 2′-aminoacetophenones

The syntheses of a diverse set of 2-aryl-4-quinolone derivatives were achieved by exposing corresponding acylated 2′-aminoacetophenones to microwave irradiation in the presence of NaOH. The microwave accelerated cyclizations were complete within 10-22 min

Transition-Metal-Free One-Pot Tandem Synthesis of 4-Quinolone and 4 H -Thiochromen-4-one Derivatives Through Sequential Nucleophilic Addition-Elimination-S N Ar Reaction

4-Quinolone and 4 H -thiochromen-4-one derivatives are readily synthesized in a tandem one-pot manner in good to excellent yields. Starting from (Z)-β-chlorovinyl ketones, an intermolecular nucleo-philic addition of amines or sodium hydrogen sulfide to (Z

Synthesis of a quinolone library from ynones

A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked β-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.

Preparation of Resin-Bound Bismethylene Cyclic Malonic Acid Ester and Facile Solid-Phase Synthesis of 2-Alkylthio-4(1H)-quinolone and 2-Alkyl-4(1H)-quinolone

The resin-bound bismethylthiomethylene cyclic malonic acid ester 3 was built up efficiently. Resin 3 can react with arylamines and subsequent thermal cyclizations give 2-alkylthio-4-(1H)-quinolones. Furthermore, conjugate addition of Grignard reagents to

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: Identification as antimitotic agents interacting with tubulin

A series of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds have been synthesized and evaluated as cytotoxic compounds and as antimitotic agents interacting with tubulin. The 2-phenyl-4-quinolones (22-30) with substituents

A Versatile Synthesis of 2-Alkyl and 2-Aryl 4-Quinolones

A versatile method for the preparation of 2-alkyl and 2-aryl-4-quinolones is described.