112421-99-5

Upstream product

• 112421-98-4 N-(2-methyl-6-phenylphenyl)benzamide 
• 98-88-4 benzoyl chloride 
• 71-43-2 benzene 
• 591-50-4 iodobenzene 
• 591-51-5 phenyllithium 
• 88-67-5 2-Iodobenzoic acid 
• 609-67-6 2-Iodobenzoyl chloride 
• 3930-83-4 o-iodobenzamide 
• 4387-36-4 2-iodobenzonitrile 
• 82617-45-6 3-methyl-2-nitro-[1,1 '-biphenyl] 
• 14294-33-8 3-methyl-[1,1'-biphenyl]-2-amine 
• 601-87-6 3-methyl-2-nitroaniline 

Downstream Products

• 112421-82-6 6-Phenyl-phenanthridine-4-carboxylic acid (4-dimethylamino-butyl)-amide; hydrochloride 
• 112421-81-5 6-Phenyl-phenanthridine-4-carboxylic acid (3-dimethylamino-propyl)-amide; hydrochloride 
• 112421-80-4 6-Phenyl-phenanthridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 112422-00-1 6-phenylphenanthridine-4-carboxylic acid 

Relevant academic research and scientific papers

Palladium-catalyzed intramolecular C(sp2)-H imidoylation for the synthesis of six-membered N-heterocycles

A new strategy for the construction of phenanthridine and isoquinoline scaffolds, starting from arenes containing a pending isocyanide moiety under palladium catalysis, has been developed. This process involves sequential intermolecular isocyanide inserti

6-Arylphenanthridines from Aryl o-Biaryl Ketones with 1,1,1,3,3,3-Hexamethyldisilazane and Molecular Iodine

Warming treatment of aryl o-biaryl ketones with 1,1,1,3,3,3-hexamethyldisilazane in the presence of Sc(OTf)3 in toluene, followed by the reaction with molecular iodine and K2CO3 in a mixture of THF and methanol at 60 °C gave the corresponding 6-arylphenanthridines in good to moderate yields. The present reaction is a one-pot method for the preparation of 6-arylphenanthridines from aryl o-biaryl ketones through the cyclization of imino-nitrogen-centered radicals that were generated from N-iodo aryl o-biaryl ketimines formed from the reaction of aryl biaryl ketimines with molecular iodine.

Preparation of Phenanthridines from o-Cyanobiaryls via Addition of Organic Lithiums to Nitriles and Imino Radical Cyclization with Iodine

Simple treatment of 2-cyanobiaryls with methyllithium, ethylmagnesium bromide, butyllithium, phenyllithium, p-methylphenyllithium, etc., followed by the reaction with water and then with molecular iodine at 60 °C provided efficiently 6-methyl-, 6-ethyl-, 6-butyl-, 6-phenyl, 6-(p-methylphenyl)phenanthridines, etc., in good yields, respectively. Here, imines formed through the addition of carbanion onto the nitriles reacted with molecular iodine to form N-iodoimines smoothly, and their warming treatment induced the formation of imino radicals that smoothly cyclized onto the aryl group to give 6-alkyl- and 6-arylphenanthridines.

Potential Antitumor Agents. 55. 6-Phenylphenanthridine-4-carboxamides: A New Class of DNA-Intercalating Antitumor Agents

Derivatives of the DNA-intercalating agent N-phenanthridine-4-carboxamide (7) have been prepared and shown to have moderate in vivo antitumor activity against both the P388 leukemia and Lewis lung carcinoma.This demonstrates that t