112607-36-0

Upstream product

• 161725-12-8 5-(4-chlorophenyl)pentanoic acid 
• 108-90-7 chlorobenzene 
• 108-55-4 glutaric anhydride, 
• 40297-26-5 (±)-2-(4-chlorophenyl)cyclopentan-1-one 
• 36978-49-1 4-(4-chlorobenzoyl)butanoic acid 
• 2371-98-4 1-(p-chlorophenyl)cyclopentene 
• 78195-98-9 1-(4-chlorophenyl)cyclopentan-1-ol 
• 106-39-8 bromochlorobenzene 
• 120-92-3 cyclopentanone 
• 122-01-0 4-chloro-benzoyl chloride 
• 1217891-10-5 1-(4-chlorophenyl)-5-hydroxypentan-1-one 

Downstream Products

• 116691-49-7 6-(4-chlorophenyl)-1-phenyl-2-piperidone 

Relevant academic research and scientific papers

Controlling Chemoselectivity of Catalytic Hydroboration with Light

The ability to selectively react one functional group in the presence of another underpins efficient reaction sequences. Despite many designer catalytic systems being reported for hydroboration reactions, which allow introduction of a functional handle fo

Stereoselective synthesis of chiral δ-lactonesviaan engineered carbonyl reductase

A carbonyl reductase variant,SmCRM5, fromSerratia marcescenswas obtained through structure-guided directed evolution. The variant showed improved specific activity (U mg?1) towards most of the 16 tested substrates and gave high stereoselectivities of up to 99% in the asymmetric synthesis of 13 γ-/δ-lactones. In particular, SmCRM5showed a 13.8-fold higher specific activity towards the model substrate,i.e., 5-oxodecanoic acid, and gave (R)-δ-decalactone in 99% ee with a space-time yield (STY) of 301 g L?1d?1. The preparative synthesis of six δ-lactones in high yields and with high enantiopurities showed the feasibility of the biocatalytic synthesis of these high-value-added chemicals, providing a cost-effective and green alternative to noble-metal catalysis.

Synthesis method of 6-(4-((2-cyclohexylthioethyl)amino)phenyl)tetrahydro-2H-pyran-2-one

The invention discloses a synthesis method and application of 6-(4-((2-cyclohexylthioethyl)amino)phenyl)tetrahydro-2H-pyran-2-one, and relates to the technical field of essence synthesis. A compound 1is prepared, and is a novel compound, and it is found that the compound has unique costustoot aroma, and the aroma is light sweet, pure, soft, good in aroma diffusivity and long in aroma retention time; meanwhile, the purity of the compound 1 reaches 99% or above, so that the essence blending requirement is met; and in addition, the compound 1 is also added into a PVC floor, so that the PVC flooremits fragrance similar to that of a solid wood floor, the use quality of the PVC floor is improved, and the problem of natural resource consumption caused by use of the solid wood floor is avoided.

Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations

Chemical transformations that install heteroatoms into C?H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C?H oxyfunctionalization, or the one step conversion of a C?H bond to a C?O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C?H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.

Cooperative iodine and photoredox catalysis for direct oxidative lactonization of carboxylic acids

A new method for the formation of γ- and δ-lactones from carboxylic acids through direct conversion of benzylic C-H to C-O bonds is described. The reaction is conveniently induced by visible light and relies on a mild cooperative catalysis by the combination of molecular iodine and an organic dye.

Regio- and enantioselective Baeyer-Villiger oxidation: Kinetic resolution of racemic 2-substituted cyclopentanones

A kinetic resolution of racemic 2-substituted cyclopentanones via highly regio- and enantioselective Baeyer-Villiger oxidation has been successfully developed. The reaction could afford the normal 6-substituted δ-lactones in up to 98% ee and >19/1 regioselectivity. Meanwhile, the unreacted ketones were recovered in excellent ee values (up to 98%). It represents the best results of the kinetic resolution of racemic 2-substituted cyclopentanones via nonenzymic asymmetric BV oxidation.

Enantioselective ketone hydroacylation using noyori's transfer hydrogenation catalyst

An enantioselective ketone hydroacylation enables the direct preparation of lactones from keto alcohols. The alcohol is oxidized in situ to an aldehyde, obviating the need to prepare sensitive keto aldehyde substrates. Noyori's asymmetric transfer hydroge

NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF

The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.

Lactam derivatives

There is disclosed a lactam derivative of the formula: STR1 wherein R1 is a substituted or unsubstituted phenyl group; R2 is a substituted or unsubstituted phenyl group, a cycloalkyl group or a nitrogen-containing 6-membered heterocy

145. Analytic and Preparative Resolution on Racemic γ- and δ-Lactones by Chromatography on Cellulose Triacetate. Relationship between Elution Order and Absolute Configuration

Enantiomers of various chiral five- and six-membered-ring lactones, which are important classes of cpmpounds (flavour and pheromone components, key intermediates in the synthesis of biologically active substrates) have been separated chromatographically on the chiral phase cellulose triacetate, crystallographic form I (CTA I).Four different series of five-membered-ring lactones, relationships have been found between the elution order of the enantiomers and their absolute configuration.Preparative resolutions of γ-phenyl-γ-butyrolactone (1) and of the pheromone component 5b have been carried out to demonstrate the applicability of the method to g-scale separations.